URCN | Unité de Recherche Clinique de NANORO

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What is already achieved

Our accomplishments are described below: 2009-Ongoing

Clinical trial

1- Mal055: Efficacy of GSK Biologicals. candidate malaria vaccine (257049) against malaria disease caused by P. falciparum infection in infants and children in Africa
2- Mal 076: Extension to study Malaria-055 PRI (110021) for evaluation of long-term efficacy, safety and immunogenicity of GSK Biologicals’ candidate malaria vaccine (SB257049) in infants and children in Africa
3- Mal063- Phase III randomized, open, controlled study to evaluate the immune response to the hepatitis B antigen of the RTS,S/AS01E candidate vaccine


1- PregACT : Pharmacokinetics of mefloquine-artesunate in pregnant women with Plasmodium falciparum infection
2- An open-label, single-arm study to evaluate the efficacy, safety and PK of artemether-lumefantrine dispersible tablet in the treatment of acute uncomplicated Plasmodium falciparum malaria in infants <5 kg body weight
3- A phase II, open-label, multicentre, pharmacokinetic, pharmacodynamics and safety study of a new paediatric eurartesim dispersible formulation and crushed film coated eurartesim tablet, in infant patients with Plasmodium falciparum malaria
4- Observational study to evaluate the clinical safety after introduction of the fixed-dose artemisinin-based combination therapy Eurartesim® (dihydroartemisinin/piperaquine [DHA/PQP]) in public health districts in Burkina Faso, Mozambique, Ghana and Tanzania
5- Pharmacovigilance : Pharmacovigilance of ACT in Africa (AL, AS-AQ)


Community based intervention
1- PaluFer : Malaria risk prior to and during early pregnancy in nulliparous women receiving long-term weekly iron and folic acid supplementation
2- AQUAMOD : Amélioration de la qualité de la consultation prénatale (CPN) et des moyens de diagnostic du paludisme au cours de la grossesse
3- COSMIC : Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial in The Gambia, Burkina Faso and Benin
Basic researches
1- Study of the incidence, reservoir and routes of transmission of invasive salmonellosis in Burkina Faso (IRTIS -BF)
2- Severe malaria and invasive bacterial disease among children: proportions, incidence rates and diagnostic value of malaria rapid diagnostic tests
3- Epidemiology study of malaria transmission intensity in sub-Saharan Africa
4- Study of immune correlates of protection against malaria after vaccination with RTS, S/AS01E
5- Genomic and environmental risk factors for cardio-metabolic disease in Africans.

Bactériurie asymptomatique chez les femmes enceintes dans les pays à faible revenus, une étude de la résistance aux antibiotiques


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