“This project is part of the EDCTP2 programme supported by the European Union”
EDCTP/AREF preparatory fellowship to study maternal antibodies and malaria protection in infancy
Dr Hamtandi Magloire NATAMA
A three-month placement at the host institution, the Barcelona Institute for Global Health (ISGlobal), will provide Dr H. Magloire Natama with the necessary training in qSAT multiplex antibody detection using Luminex® platform, immune cell isolation, stimulation, phenotyping and quantification using flow cytometry, data quality control and analysis). ISGlobal also offers the facilities to analyze a set of cord blood samples (n=715) for maternal antibody detection. The objectives of the project are to 1) generate data on maternal antibodies (IgG/subclasses) relevant for malaria protection during the first months of life, which will guide future studies on malaria immunology in early childhood; 2) acquire skills and competence in immunological techniques and methods, and; 3) develop a compelling proposal for funding after the fellowship. The placement will be followed by a three-month reintegration period at the home institution. This will be used to train peers on a set of immunological techniques. Moreover, the fellow will complete the statistical analysis, data interpretation and preparation of a publication on the maternal antibodies research and continue the development of Dr Natama’s follow-on project based on the research outputs from the placement.
Although infants are thought to be protected against malaria during the first months of life mainly due to maternal antibodies, malaria in early childhood is not uncommon in high- transmission settings. Susceptibility to the infections varies between individuals and, therefore, putting into question the protective effect of maternal antibodies. In such a context, factors that modulate malaria risk/protection in early childhood are not fully understood. Further field studies focusing on the role of maternal antibodies are needed.
he preparatory fellowship will have an impact at several levels. First, it will contribute knowledge of the role of maternal antibodies in malaria protection in infants living in malaria- endemic settings, promote high-quality malaria immunology research and build capacity through the training of colleagues. Secondly, it will prepare the home institution (laboratory development) for future immunological malaria studies and strengthen the relationship with ISGlobal. Thirdly, the fellow will consolidate his skills and competence in malaria immunology research, his competitiveness in attracting grants and establish himself as an independent malaria researcher in his home institution.
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