Publications

@article{Chikwati2023,

title = {Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study},

author = {Raylton P. Chikwati and Nasrin Goolam Mahyoodeen and Nicole G. Jaff and Michele Ramsay and Lisa K. Micklesfield and Alisha N. Wade and Godfred Agongo and Gershim Asiki and Solomon S. R. Choma and Palwende R. Boua and Jaya A. George and Nigel J. Crowther},

url = {https://pubmed.ncbi.nlm.nih.gov/37116348/},

doi = {10.1016/J.MATURITAS.2023.04.005},

issn = {1873-4111},

year  = {2023},

date = {2023-01-01},

journal = {Maturitas},

volume = {172},

pages = {60-68},

publisher = {Maturitas},

abstract = {Objective: To compare the risk factors for cardiometabolic disease between pre- and postmenopausal women from four sub-Saharan African countries. Study design: This cross-sectional study included 3609 women (1740 premenopausal and 1869 postmenopausal) from sites in Ghana (Navrongo), Burkina Faso (Nanoro), Kenya (Nairobi), and South Africa (Soweto and Dikgale). Demographic, anthropometric and cardiometabolic variables were compared between pre- and postmenopausal women, within and across sites using multivariable regression analyses. The sites represent populations at different stages of the health transition, with those in Ghana and Burkina Faso being rural, whilst those in Kenya and South Africa are more urbanised. Main outcome measures: Anthropometric and cardiometabolic variables. Results: The prevalence rates of risk factors for cardiometabolic disease were higher in South (Soweto and Dikgale) and East (Nairobi) Africa than in West Africa (Nanoro and Navrongo), irrespective of menopausal status. Regression models in combined West African populations demonstrated that postmenopausal women had a larger waist circumference (β = 1.28 (95 % CI: 0.58; 1.98) cm), log subcutaneous fat (β =0.15 (0.10; 0.19)), diastolic (β = 3.04 (1.47; 4.62) mm Hg) and log systolic (β = 0.04 (0.02; 0.06)) blood pressure, log carotid intima media thickness (β = 0.03 (0.01; 0.06)), low-density lipoprotein cholesterol (β = 0.14 (0.04; 0.23) mmol/L) and log triglyceride (β= 0.10 (0.04; 0.16)) levels than premenopausal women. No such differences were observed in the South and East African women. Conclusions: Menopause-related differences in risk factors for cardiometabolic disease were prominent in West but not East or South African study sites. These novel findings should inform cardiometabolic disease prevention strategies in midlife women specific to rural and urban and peri-urban locations in sub-Saharan Africa.},

keywords = {Cardiovascular Diseases* / epidemiology, Cardiovascular Diseases* / etiology, Carotid intima-media thickness, Cross-Sectional Studies, doi:10.1016/j.maturitas.2023.04.005, Female, Humans, Kenya, MEDLINE, Nasrin Goolam Mahyoodeen, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, Nigel J Crowther, NIH, NLM, PMC10278059, pmid:37116348, Postmenopause*, PubMed Abstract, Raylton P Chikwati, Risk Factors, South Africa / epidemiology},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Incidence rate and predictors of COVID-19 in the two largest cities of Burkina Faso - prospective cohort study in 2021 (ANRS-COV13)},

author = {Nongodo Firmin Kabor\'{e} and Samiratou Ou\'{e}draogo and Ariane Kamga Mamguem and Isidore Tiandiogo Traor\'{e} and Dramane Kania and Hermann Badolo and Guillaume Sanou and Amariane Kon\'{e} and Mimbour\'{e} Yara and Th\'{e}r\`{e}se Kagon\'{e} and Esperance Ou\'{e}draogo and Blahima Konat\'{e} and Rachel M\'{e}dah and Nathalie Rekeneire and Armel Poda and Arnaud Eric Diend\'{e}r\'{e} and Boukary Ou\'{e}draogo and Oumar Billa and Gilles Paradis and Tienhan Sandrine Dabakuyo-Yonli and Halidou Tinto},

url = {https://pubmed.ncbi.nlm.nih.gov/37308819/},

doi = {10.1186/S12879-023-08361-2},

issn = {1471-2334},

year  = {2023},

date = {2023-01-01},

journal = {BMC infectious diseases},

volume = {23},

issue = {1},

publisher = {BMC Infect Dis},

abstract = {Background: Early data on COVID-19 (based primarily on PCR testing) indicated a low burden in Sub-Saharan Africa. To better understand this, this study aimed to estimate the incidence rate and identify predictors of SARS-CoV-2 seroconversion in the two largest cities of Burkina Faso. This study is part of the EmulCOVID-19 project (ANRS-COV13). Methods: Our study utilized the WHO Unity protocol for cohort sero-epidemiological studies of COVID-19 in general population. We conducted random sampling stratified by age group and sex. Individuals aged 10 years and older in the cities of Ouagadougou and Bobo-Dioulasso, Burkina Faso were included and surveyed at 4 time points, each 21 days apart, from March 3 to May 15, 2021. WANTAI SARS-CoV-2 Ab ELISA serological tests were used to detect total antibodies (IgM, IgG) in serum. Predictors were investigated using Cox proportional hazards regression. Results: We analyzed the data from 1399 participants (1051 in Ouagadougou, 348 in Bobo-Dioulasso) who were SARS-CoV-2 seronegative at baseline and had at least one follow-up visit. The incidence rate of SARS-CoV-2 seroconversion was 14.3 cases [95%CI 13.3\textendash15.4] per 100 person-weeks. The incidence rate was almost three times higher in Ouagadougou than in Bobo-Dioulasso (Incidence rate ratio: IRR = 2.7 [2.2\textendash3.2], p \< 0.001). The highest incidence rate was reported among women aged 19\textendash59 years in Ouagadougou (22.8 cases [19.6\textendash26.4] per 100 person-weeks) and the lowest among participants aged 60 years and over in Bobo-Dioulasso, 6.3 cases [4.6\textendash8.6] per 100 person-weeks. Multivariable analysis showed that participants aged 19 years and older were almost twice as likely to seroconvert during the study period compared with those aged 10 to 18 years (Hazard ratio: HR = 1.7 [1.3\textendash2.3], p \< 0.001). Those aged 10\textendash18 years exhibited more asymptomatic forms than those aged 19 years and older, among those who achieved seroconversion (72.9% vs. 40.4%, p \< 0.001). Conclusion: The spread of COVID-19 is more rapid in adults and in large cities. Strategies to control this pandemic in Burkina Faso, must take this into account. Adults living in large cities should be the priority targets for vaccination efforts against COVID-19.},

keywords = {Adult, Aged, Burkina Faso, Cities, COVID-19*, doi:10.1186/s12879-023-08361-2, Female, Halidou Tinto, Humans, Incidence, MEDLINE, Middle Aged, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nongodo Firmin Kabor\'{e}, PMC10258776, pmid:37308819, Prospective Studies, PubMed Abstract, Samiratou Ou\'{e}draogo, SARS-Cov-2},

pubstate = {published},

tppubtype = {article}

}

@article{Sondo2023,

title = {Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial},

author = {Paul Sondo and B\'{e}renger Kabor\'{e} and Toussaint Rouamba and Eulalie Compaor\'{e} and Yssimini Nad\`{e}ge Guill\`{e}ne Tibiri and Hyacinthe Abd El Latif Fa\"{i}\c{c}al Kabor\'{e} and Karim Derra and Marc Christian Tahita and Hamidou Ilboudo and Gauthier Tougri and Isma\"{i}la Bouda and Tikanou Dakyo and Hyacinthe Kafando and Florence Ou\'{e}draogo and Eli Rouamba and So Franck Hien and Adama Kazienga and Cheick Sa\"{i}d Compaor\'{e} and Estelle Bambara and Macaire Nana and Prabin Dahal and Franck Garanet and William Kabor\'{e} and Thierry L\'{e}f\`{e}vre and Philippe Guerin and Halidou Tinto},

url = {https://pubmed.ncbi.nlm.nih.gov/37853408/},

doi = {10.1186/S12936-023-04745-6},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. Methods: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A},

keywords = {Antimalarials* / therapeutic use, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Chemoprevention, Child, Cross-Sectional Studies, Dietary Supplements, doi:10.1186/s12936-023-04745-6, Halidou Tinto, Humans, Infant, Malaria* / epidemiology, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nutrients, Paul Sondo, PMC10585892, pmid:37853408, Preschool, PubMed Abstract, Randomized controlled trial, Seasons, Vitamin A / therapeutic use},

pubstate = {published},

tppubtype = {article}

}

@article{Unger2023,

title = {Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis},

author = {Holger W. Unger and Anastasia Jessica Hadiprodjo and Julie R. Gutman and Valerie Briand and Nadine Fievet and Innocent Valea and Halidou Tinto and Umberto D’Alessandro and Sarah H. Landis and Feiko Ter Kuile and Peter Ouma and Martina Oneko and Victor Mwapasa and Laurence Slutsker and Dianne J. Terlouw and Simon Kariuki and John Ayisi and Bernard Nahlen and Meghna Desai and Mwayi Madanitsa and Linda Kalilani-Phiri and Per Ashorn and Kenneth Maleta and Antoinette Tshefu-Kitoto and Ivo Mueller and Danielle Stanisic and Jordan Cates and Anna Maria Van Eijk and Maria Ome-Kaius and Elizabeth H. Aitken and Stephen J. Rogerson},

url = {https://pubmed.ncbi.nlm.nih.gov/37365258/},

doi = {10.1038/S41598-023-37431-3},

issn = {2045-2322},

year  = {2023},

date = {2023-01-01},

journal = {Scientific reports},

volume = {13},

issue = {1},

publisher = {Sci Rep},

abstract = {In areas of moderate to intense Plasmodium falciparum transmission, malaria in pregnancy remains a significant cause of low birth weight, stillbirth, and severe anaemia. Previously, fetal sex has been identified to modify the risks of maternal asthma, pre-eclampsia, and gestational diabetes. One study demonstrated increased risk of placental malaria in women carrying a female fetus. We investigated the association between fetal sex and malaria in pregnancy in 11 pregnancy studies conducted in sub-Saharan African countries and Papua New Guinea through meta-analysis using log binomial regression fitted to a random-effects model. Malaria infection during pregnancy and delivery was assessed using light microscopy, polymerase chain reaction, and histology. Five studies were observational studies and six were randomised controlled trials. Studies varied in terms of gravidity, gestational age at antenatal enrolment and bed net use. Presence of a female fetus was associated with malaria infection at enrolment by light microscopy (risk ratio 1.14 [95% confidence interval 1.04, 1.24]; P = 0.003; n = 11,729). Fetal sex did not associate with malaria infection when other time points or diagnostic methods were used. There is limited evidence that fetal sex influences the risk of malaria infection in pregnancy.},

keywords = {Anastasia Jessica Hadiprodjo, doi:10.1038/s41598-023-37431-3, Extramural, Falciparum* / complications, Falciparum* / epidemiology, Female, Holger W Unger, Humans, Infant, Low Birth Weight, Malaria, Malaria* / complications, Malaria* / epidemiology, MEDLINE, Meta-Analysis, N.I.H., National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, Newborn, NIH, NLM, Non-U.S. Gov't, placenta, Plasmodium falciparum, PMC10293221, pmid:37365258, Pregnancy, PubMed Abstract, Research Support, Stephen J Rogerson, Stillbirth},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis},

author = {Anna Maria Eijk and Kasia Stepniewska and Jenny Hill and Steve M. Taylor and Stephen J. Rogerson and Gilles Cottrell and R. Matthew Chico and Julie R. Gutman and Halidou Tinto and Holger W. Unger and Stephanie K. Yanow and Steven R. Meshnick and Feiko O. Kuile and Alfredo Mayor and Steve M. Taylor and Stephen J. Rogerson and R. Matthew Chico and Julie R. Gutman and Hallidou Tinto and Holger W. Unger and Stephanie K. Yanow and Manfred Accrombessi and Ayola A. Adegnika and Rukhsana Ahmed and Eliana Mar\'{i}a Arango-Fl\'{o}rez and Myriam Arevalo-Herrera and Emmanual Arinaitwe and Paulo Arnaldo and Per Ashorn and Ulla Ashorn and Azucena Bardaji and Inoni Betuela and Praveen K. Bharti and Francis Bohissou and Camila B\^{o}tto-Menezes and Vera Braun and Valerie Briand and Jessica Briggs and Mar\'{i}a Eugenia Castellanos and Daniel Chandramohan and Enesia Banda Chaponda and Chetan Chitnis and Lauren M. Cohee and Michel Cot and Umberto d'Alessandro and Lise Denoeud-Ndam and Meghna Desai and Alassane Dicko and Xavier Ding and Grant Dorsey and Patrick E. Duffy and Maha A. Elbadry and Sonia M. Enosse and Yue Fan and Nadine Fievet and Michal Fried and Blaise Genton and Raquel Gonzalez and Brian Greenwood and Linda Kalilani and Johanna H. Kattenberg and Kassoum Kayentao and Carole Khairallah and Christopher L. King and Dhanpat Kumar Kochar and Swati Kochar and Felix Koukouikila-Koussounda and Sarah H. Landis and Miriam K. Laufer and Rose F. Leke and Eusebio Macete and Sonia Maculuve and Mwayiwawo Madanitsa and Almahamoudou Mahamar and Ken Maleta and Indu Malhotra and Rella Zoleko Manego and Flor Ernestina Martinez-Espinosa and Achille Massougbodji and Don Mathanga and Michela Menegon and Clara Menendez and Petra Mens and Martin Meremikwu and Frank P. Mockenhaupt and Ghyslain Mombo-Ngoma and Dominic Mosha and Ivo Mueller and Alain Nahum and Paul Natureeba and Nicaise Ndam and Francine Ntoumi and Olabisi A. Oduwole and Bernard A. Okech and Maria Ome-Kaius and Kephas Otieno and Norma Padilla and Michal Ramharter and Rosemary Rochford and Anna Rosanas-Urgell and Maria Ruperez and Katherine R. Sabourin and Sergi Sanz and Henk D. Schallig and Susana Scott and Esperanca Sevene and Carlo Severini and Harry Tagbor and Diane Wallace Taylor and Maminata Traore Coulibaly and Ana Vasquez and Annie Walker-Abbey and Blair J. Wylie and Djimon M. Zannou and Stephen R. Meshnick},

url = {https://pubmed.ncbi.nlm.nih.gov/37276878/},

doi = {10.1016/S2214-109X(23)00194-8},

issn = {2214-109X},

year  = {2023},

date = {2023-01-01},

journal = {The Lancet. Global health},

volume = {11},

issue = {7},

pages = {e1061-e1074},

publisher = {Lancet Glob Health},

abstract = {Background: Malaria infections during pregnancy can cause adverse birth outcomes, yet many infections are undetected by microscopy. We aimed to describe the epidemiology of submicroscopic malaria infections in pregnant women in Asia, the Americas, and Africa using aggregated and individual participant data (IPD). Methods: For this systematic review and meta-analysis, studies (published Jan 1, 1997 to Nov 10, 2021) with information on both microscopic and submicroscopic infections during pregnancy from Asia, the Americas, or Africa, identified in the Malaria-in-Pregnancy Library, were eligible. Studies (or subgroups or study groups) that selected participants on the basis of the presence of fever or a positive blood smear were excluded to avoid selection bias. We obtained IPD (when available) and aggregated data. Estimates of malaria transmission intensity and sulfadoxine\textendashpyrimethamine resistance, matched by study location and year, were obtained using publicly available data. One-stage multivariable logit and multinomial models with random intercepts for study site were used in meta-analysis to assess prevalence of and risk factors for submicroscopic infections during pregnancy and at delivery. This study is registered with PROSPERO, number CRD42015027342. Findings: The search identified 87 eligible studies, 68 (78%) of which contributed to the analyses. Of these 68 studies, 45 (66%) studies contributed IPD (48 869 participants) and 23 (34%) studies contributed aggregated data (11 863 participants). During pregnancy, median prevalence estimates were 13·5% (range 0·0\textendash55·9, 66 substudies) for submicroscopic and 8·0% (0·0\textendash50·6, 66 substudies) for microscopic malaria. Among women with positive Plasmodium nucleic acid amplification tests (NAATs), the median proportion of submicroscopic infections was 58·7% (range 0·0\textendash100); this proportion was highest in the Americas (73·3%, 0·0\textendash100), followed by Asia (67·2%, 36·4\textendash100) and Africa (56·5%, 20·5\textendash97·7). In individual patient data analysis, compared with women with no malaria infections, those with submicroscopic infections were more likely to present with fever in Africa (adjusted odds ratio 1·32, 95% CI 1·02\textendash1·72; p=0·038) but not in other regions. Among women with NAAT-positive infections in Asia and the Americas, Plasmodium vivax infections were more likely to be submicroscopic than Plasmodium falciparum infections (3·69, 2·45\textendash5·54; p\<0·0001). Risk factors for submicroscopic infections among women with NAAT-positive infections in Africa included older age (age ≥30 years), multigravidity, and no HIV infection. Interpretation: During pregnancy, submicroscopic infections are more common than microscopic infections and are associated with fever in Africa. Malaria control in pregnancy should target both microscopic and submicroscopic infections. Funding: Bill \& Melinda Gates Foundation through the Worldwide Antimalarial Resistance Network.},

keywords = {{Adult, Anna Maria van Eijk, Antimalarials* / therapeutic use, Author(firstnames='Achille', Author(firstnames='Alain', Author(firstnames='Alassane', Author(firstnames='Alfredo', Author(firstnames='Almahamoudou', Author(firstnames='Ana', Author(firstnames='Anna', Author(firstnames='Annie', Author(firstnames='Ayola A', Author(firstnames='Azucena', Author(firstnames='Bernard A', Author(firstnames='Blair J', Author(firstnames='Blaise', Author(firstnames='Brian', Author(firstnames='Camila', Author(firstnames='Carlo', Author(firstnames='Carole', Author(firstnames='Chetan', Author(firstnames='Christopher L', Author(firstnames='Clara', Author(firstnames='Daniel', Author(firstnames='Dhanpat Kumar', Author(firstnames='Diane Wallace', Author(firstnames='Djimon M', Author(firstnames='Dominic', Author(firstnames='Don', Author(firstnames='Eliana Mar\'{i}a', Author(firstnames='Emmanual', Author(firstnames='Enesia Banda', Author(firstnames='Esperanca', Author(firstnames='Eusebio', Author(firstnames='Feiko O', Author(firstnames='Felix', Author(firstnames='Flor Ernestina', Author(firstnames='Francine', Author(firstnames='Francis', Author(firstnames='Frank P', Author(firstnames='Ghyslain', Author(firstnames='Gilles', Author(firstnames='Grant', Author(firstnames='Hallidou', Author(firstnames='Harry', Author(firstnames='Henk D', Author(firstnames='Holger W', Author(firstnames='Indu', Author(firstnames='Inoni', Author(firstnames='Ivo', Author(firstnames='Jenny', Author(firstnames='Jessica', Author(firstnames='Johanna H', Author(firstnames='Julie R', Author(firstnames='Kasia', Author(firstnames='Kassoum', Author(firstnames='Katherine R', Author(firstnames='Ken', Author(firstnames='Kephas', Author(firstnames='Lauren M', Author(firstnames='Linda', Author(firstnames='Lise', Author(firstnames='Maha A', Author(firstnames='Maminata', Author(firstnames='Manfred', Author(firstnames='Mar\'{i}a Eugenia', Author(firstnames='Maria', Author(firstnames='Martin', Author(firstnames='Meghna', Author(firstnames='Michal', Author(firstnames='Michel', Author(firstnames='Michela', Author(firstnames='Miriam K', Author(firstnames='Mwayiwawo', Author(firstnames='Myriam', Author(firstnames='Nadine', Author(firstnames='Nicaise', Author(firstnames='Norma', Author(firstnames='Olabisi A', Author(firstnames='Patrick E', Author(firstnames='Paul', Author(firstnames='Paulo', Author(firstnames='Per', Author(firstnames='Petra', Author(firstnames='Praveen K', Author(firstnames='R Matthew', Author(firstnames='Raquel', Author(firstnames='Rella', Author(firstnames='Rose F', Author(firstnames='Rosemary', Author(firstnames='Rukhsana', Author(firstnames='Sarah H', Author(firstnames='Sergi', Author(firstnames='Sonia M', Author(firstnames='Sonia', Author(firstnames='Stephanie K', Author(firstnames='Stephen J', Author(firstnames='Stephen R', Author(firstnames='Steve M', Author(firstnames='Susana', Author(firstnames='Swati', Author(firstnames='Ulla', Author(firstnames='Umberto', Author(firstnames='Valerie', Author(firstnames='Vera', Author(firstnames='Xavier', Author(firstnames='Yue', CollabAuthor(name='Subpatent Malaria in Pregnancy Group', Falciparum* / drug therapy, Female, Humans, Kasia Stepniewska, Malaria, Malaria* / prevention \& control, MEDLINE, Meta-Analysis, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, P.H.S., PMC10880462, Pregnancy, Prevalence, PubMed Abstract, Research Support, Risk Factors, Systematic review, U.S. Gov't},

pubstate = {published},

tppubtype = {article}

}

@article{Olliaro2023,

title = {Synthesis and Meta-analysis of 3 Randomized Trials Conducted in Burkina Faso, Ghana, and Uganda Comparing the Effects of Point-of-Care Tests and Diagnostic Algorithms Versus Routine Care on Antibiotic Prescriptions and Clinical Outcomes in Ambulatory Patients \<18 Years of Age With Acute Febrile Illness},

author = {Piero Olliaro and Juvenal Nkeramahame and Philip Horgan and Halidou Tinto and Fran\c{c}ois Kiemde and Rita Baiden and Alexander Adjei and James Kapisi and Heidi Hopkins and Olawale Salami and Catrin E. Moore and Sabine Dittrich and Stephan Weber and Stefano Ongarello},

url = {https://pubmed.ncbi.nlm.nih.gov/37490743/},

doi = {10.1093/CID/CIAD324},

issn = {1537-6591},

year  = {2023},

date = {2023-01-01},

journal = {Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},

volume = {77},

issue = {Suppl 2},

pages = {S199-S205},

publisher = {Clin Infect Dis},

keywords = {{Algorithms, Anti-Bacterial Agents* / therapeutic use, Author(firstnames='Ad\'{e}la\"{i}de', Author(firstnames='Alexander', Author(firstnames='Asadu', Author(firstnames='Daniel', Author(firstnames='David', Author(firstnames='Deborah', Author(firstnames='Elizeus', Author(firstnames='Fran\c{c}ois', Author(firstnames='Freddy Eric', Author(firstnames='Halidou', Author(firstnames='Heidi', Author(firstnames='James', Author(firstnames='Rita', Author(firstnames='Vida', Burkina Faso, CollabAuthor(name='ADIP study group', Diagnostic Tests, Ghana, Humans, Juvenal Nkeramahame, MEDLINE, Meta-Analysis, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, Piero Olliaro, PMC10368413, Point-of-Care Testing*, Prescriptions, PubMed Abstract, Randomized Controlled Trials as Topic, Research Support},

pubstate = {published},

tppubtype = {article}

}

@article{Kiemde2023,

title = {A Randomized Trial to Assess the Impact of a Package of Diagnostic Tools and Diagnostic Algorithm on Antibiotic Prescriptions for the Management of Febrile Illnesses Among Children and Adolescents in Primary Health Facilities in Burkina Faso},

author = {Francois Kiemde and Daniel Valia and Berenger Kabore and Toussaint Rouamba and Alima Nadine Kone and Seydou Sawadogo and Adelaide Compaore and Olawale Salami and Philip Horgan and Catrin E. Moore and Sabine Dittrich and Juvenal Nkeramahame and Piero Olliaro and Halidou Tinto},

url = {https://pubmed.ncbi.nlm.nih.gov/37490742/},

doi = {10.1093/CID/CIAD331},

issn = {1537-6591},

year  = {2023},

date = {2023-01-01},

journal = {Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},

volume = {77},

issue = {Suppl 2},

pages = {S134-S144},

publisher = {Clin Infect Dis},

abstract = {Background: Low- and middle-income countries face significant challenges in differentiating bacterial from viral causes of febrile illnesses, leading to inappropriate use of antibiotics. This trial aimed to evaluate the impact of an intervention package comprising diagnostic tests, a diagnostic algorithm, and a training-and-communication package on antibiotic prescriptions and clinical outcomes. Methods: Patients aged 6 months to 18 years with fever or history of fever within the past 7 days with no focus, or a suspected respiratory tract infection, arriving at 2 health facilities were randomized to either the intervention package or standard practice. The primary outcomes were the proportions of patients who recovered at day 7 (D7) and patients prescribed antibiotics at day 0. Results: Of 1718 patients randomized, 1681 (97.8%; intervention: 844; control: 837) completed follow-up: 99.5% recovered at D7 in the intervention arm versus 100% in standard practice (P =. 135). Antibiotics were prescribed to 40.6% of patients in the intervention group versus 57.5% in the control arm (risk ratio: 29.3%; 95% CI: 21.8-36.0%; risk difference [RD]: -16.8%; 95% CI: -21.7% to -12.0%; P \<. 001), which translates to 1 additional antibiotic prescription saved every 6 (95% CI: 5-8) consultations. This reduction was significant regardless of test results for malaria, but was greater in patients without malaria (RD: -46.0%; -54.7% to -37.4%; P \<. 001), those with a respiratory diagnosis (RD: -38.2%; -43.8% to -32.6%; P \<. 001), and in children 6-59 months old (RD: -20.4%; -26.0% to -14.9%; P \<. 001). Except for the period July-September, the reduction was consistent across the other quarters (P \<. 001). Conclusions: The implementation of the package can reduce inappropriate antibiotic prescription without compromising clinical outcomes. Clinical Trials Registration: clinicaltrials.gov; NCT04081051.},

keywords = {Adolescent, Algorithms, Anti-Bacterial Agents* / therapeutic use, Burkina Faso, Child, Daniel Valia, doi:10.1093/cid/ciad331, Francois Kiemde, Halidou Tinto, Health Facilities, Humans, Infant, Malaria* / drug therapy, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, PMC10368409, pmid:37490742, Preschool, Prescriptions, PubMed Abstract, Randomized controlled trial, Research Support},

pubstate = {published},

tppubtype = {article}

}

@article{Compaore2023,

title = {Viewpoint: Antimicrobial Resistance Diagnostics Use Accelerator: Qualitative Research on Adherence to Prescriptions},

author = {Adela\"{i}de Compaore and Deborah Ekusai-Sebatta and David Kaawa-Mafigiri and Vida Kukula and Selase Odopey and James Kapisi and Heidi Hopkins and Fran\c{c}ois Kiemde and Halidou Tinto and Rita Baiden and Piero Olliaro and Juvenal Nkeramahame and Sabine Dittrich and Philip Horgan},

url = {https://pubmed.ncbi.nlm.nih.gov/37490738/},

doi = {10.1093/CID/CIAD323},

issn = {1537-6591},

year  = {2023},

date = {2023-01-01},

journal = {Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},

volume = {77},

issue = {Suppl 2},

pages = {S206-S210},

publisher = {Clin Infect Dis},

abstract = {In this Viewpoint, the authors explore the determinants of patients' prescription adherence behaviors as part of FIND's Advancing Access to Diagnostic Innovation essential for Universal Health Coverage and AMR Prevention (ADIP) trials (ClinicalTrials.gov identifier: NCT04081051). Research findings from Burkina Faso, Ghana, and Uganda show that basic knowledge and understanding of prescription instructions are essential for adherence and can be improved through better communication. However, there are a range of other factors that influence adherence, some of which can be influenced through tailored communication messages from healthcare workers. These messages may contribute to changes in adherence behavior but may require other reinforcing interventions to be effective. Finally, there are some drivers of nonadherence centered around costs and time pressure that require other forms of intervention.},

keywords = {{Ad\'{e}la\"{i}de Compaor\'{e}, Anti-Bacterial Agents* / therapeutic use, Author(firstnames='Ad\'{e}la\"{i}de', Author(firstnames='Alexander', Author(firstnames='Asadu', Author(firstnames='Daniel', Author(firstnames='David', Author(firstnames='Deborah', Author(firstnames='Elizeus', Author(firstnames='Fran\c{c}ois', Author(firstnames='Freddy Eric', Author(firstnames='Halidou', Author(firstnames='Heidi', Author(firstnames='James', Author(firstnames='Rita', Author(firstnames='Vida', Bacterial*, Clinical Trial, CollabAuthor(name='ADIP study group', Communication, Deborah Ekusai-Sebatta, Drug Resistance, Humans, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, PMC10368411, Prescriptions, PubMed Abstract, Qualitative research, Research Support},

pubstate = {published},

tppubtype = {article}

}

@article{Lompo2023,

title = {Growth of Gram-Negative Bacteria in Antiseptics, Disinfectants and Hand Hygiene Products in Two Tertiary Care Hospitals in West Africa\textemdashA Cross-Sectional Survey},

author = {Palpouguini Lompo and Anne Sophie Heroes and Esenam Agbobli and Adama Kazienga and Marjan Peeters and Halidou Tinto and Katrien Lagrou and Lassana Sangar\'{e} and Dissou Affolabi and Jan Jacobs},

url = {https://www.mdpi.com/2076-0817/12/7/917/htm https://www.mdpi.com/2076-0817/12/7/917},

doi = {10.3390/PATHOGENS12070917/S1},

issn = {20760817},

year  = {2023},

date = {2023-01-01},

journal = {Pathogens},

volume = {12},

issue = {7},

pages = {917},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

abstract = {Antiseptics, disinfectants, and hand hygiene products can act as reservoirs of Gram-negative bacteria causing healthcare-associated infections. This problem is rarely documented in low- and middle-income countries, particularly in sub-Saharan Africa. In a cross-sectional survey, we assessed the bacterial contamination of antiseptics, disinfectants, and hand hygiene products in two university hospitals in Burkina Faso and Benin. During ward visits and staff interviews, in-use products were cultured for the presence of Gram-negative bacteria. The growth of Gram-negative bacteria was absent or rare in alcohol-based products, povidone iodine, and Dakin solution. Contamination was highest (73.9% (51/69)) for liquid soap products (versus antiseptic/disinfectants (4.5%, 7/157) (p \< 0.0001)), mostly used in high-risk areas and associated with high total bacterial counts (\>10,000 colony-forming units/mL). Contaminating flora (105 isolates) included Enterobacterales and the Vibrio non-cholerae/Aeromonas group (17.1%) and non-fermentative Gram-negative rods (82.8%). Multidrug resistance was present among 9/16 Enterobacterales (Klebsiella and Enterobacter spp.) and 3/12 Acinetobacter spp., including carbapenem resistance (Acinetobacter baumannii: NDM, Pseudomonas stutzeri: VIM). The risk factors for contamination included the type of product (cleaning grade and in-house prepared liquid soap), use of recycled disposable containers and soft drink bottles, absence of labeling, topping-up of containers, dilution with tap water (pharmacy and ward), and poor-quality management (procurement, stock management, expiry dates, and period after opening).},

keywords = {antiseptics, bacteria, cross-sectional, disinfectants, Gram-negative, hand hygiene, healthcare-associated infections, low-and middle-income countries, resistance, West Africa},

pubstate = {published},

tppubtype = {article}

}

@article{Agnandji2023,

title = {Prostration and the prognosis of death in African children with severe malaria},

author = {Selidji T. Agnandji and Mario Recker and Benjamin Mordm\"{u}ller and Stephan Gl\"{o}ckner and Akim A. Adegnika and Bertrand Lell and Lucas Otieno and Walter Otieno and Seth Owusu-Agyei and Kwaku P. Asante and Tsiri Agbenyega and Daniel Ansong and Eusebio Macete and Pedro Aide and Hermann Sorgho and Halidou Tinto and Neema Mturi and John P. A. Lusingu and Samwel Gesase and Irving Hoffman and Nahya Salim Masoud and Charles R. Newton and Kalifa Bojang and G\'{e}rard Krause and Peter Gottfried Kremsner},

url = {https://pubmed.ncbi.nlm.nih.gov/37414210/},

doi = {10.1016/J.IJID.2023.06.022},

issn = {1878-3511},

year  = {2023},

date = {2023-01-01},

journal = {International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},

volume = {134},

pages = {240-247},

publisher = {Int J Infect Dis},

abstract = {Objectives: Malaria is still one of the main reasons for hospitalization in children living in sub-Saharan Africa. Rapid risk stratification at admission is essential for optimal medical care and improved prognosis. Whereas coma, deep breathing, and, to a lesser degree, severe anemia are established predictors of malaria-related death, the value of assessing prostration for risk stratification is less certain. Methods: Here we used a retrospective multi-center analysis comprising over 33,000 hospitalized children from four large studies, including two observational studies from the Severe Malaria in African Children network, a randomized controlled treatment study, and the phase-3-clinical RTS,S-malaria vaccine trial, to evaluate known risk factors of mortality and with a specific emphasis on the role of prostration. Results: Despite comparable age profiles of the participants, we found significant inter- and intra-study variation in the incidence of fatal malaria as well as in the derived risk ratios associated with the four risk factors: coma, deep breathing, anemia, and prostration. Despite pronounced variations, prostration was significantly associated with an increased risk of mortality (P \<0.001) and its consideration resulted in improved predictive performance, both in a multivariate model and a univariate model based on the Lambar\'{e}n\'{e} Organ Dysfunction Score. Conclusion: Prostration is an important clinical criterion to determine severe pediatric malaria with possible fatal outcomes.},

keywords = {Anemia*, Child, Clinical Trial, Coma, doi:10.1016/j.ijid.2023.06.022, Falciparum* / drug therapy, Humans, Infant, Malaria, Malaria* / complications, Malaria* / diagnosis, Mario Recker, MEDLINE, Multicenter Study, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peter Gottfried Kremsner, Phase III, pmid:37414210, Prognosis, PubMed Abstract, Randomized controlled trial, Selidji T Agnandji},

pubstate = {published},

tppubtype = {article}

}

@article{Neyer2023,

title = {Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study},

author = {Peter J. Neyer and B\'{e}renger Kabor\'{e} and Christos T. Nakas and Britta Hartmann and Annelies Post and Salou Diallo and Halidou Tinto and Angelika Hammerer-Lercher and Carlo R. Largiad\`{e}r and Andre J. Ven and Andreas R. Huber},

url = {https://pubmed.ncbi.nlm.nih.gov/37658365/},

doi = {10.1186/S12936-023-04686-0},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: Asymptomatic Plasmodium falciparum parasitaemia forms a reservoir for the transmission of malaria disease in West Africa. Certain haemoglobin variants are known to protect against severe malaria infection. However, data on the potential roles of haemoglobin variants and nongenetic factors in asymptomatic malaria infection is scarce and controversial. Therefore, this study investigated the associations of iron homeostasis, inflammation, nutrition, and haemoglobin mutations with parasitaemia in an asymptomatic cohort from a P. falciparum-endemic region during the high transmission season. Methods: A sub-study population of 688 asymptomatic individuals (predominantly children and adolescents under 15 years},

keywords = {Adolescent, Andreas R Huber, Asymptomatic Infections / epidemiology, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Child, doi:10.1186/s12936-023-04686-0, Falciparum* / epidemiology, hemoglobin, Hepcidins*, Humans, Malaria, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peter J Neyer, Plasmodium falciparum / genetics, PMC10474782, pmid:37658365, PubMed Abstract, Sickle},

pubstate = {published},

tppubtype = {article}

}

@article{Boua2023,

title = {Undernutrition in children aged 0-59 months by region and over time: secondary analysis of the Burkina Faso 2012-2018 National Nutrition Surveys},

author = {Palwende Romuald Boua and Toussaint Rouamba and Estelle Bambara and Saidou Kabor\'{e} and Ella W. R. Compaore and Boureima Ouedraogo and Halidou Tinto and Marie Louise Newell and Kate Ward and Hermann Sorgho},

url = {https://pubmed.ncbi.nlm.nih.gov/37673454/},

doi = {10.1136/BMJOPEN-2022-066509},

issn = {2044-6055},

year  = {2023},

date = {2023-01-01},

journal = {BMJ open},

volume = {13},

issue = {9},

publisher = {BMJ Open},

abstract = {The global burden of undernutrition remains high, responsible for significant under-five mortality in resource-limited settings. Numerous sustainable development goals (SDGs) are linked to nutrition, and nationally representative nutrition surveillance is a key activity to track progress towards SDGs and guide efficient programmes. Objectives The aim of this study is to look at spatial and temporal trends in undernutrition in children under 5 years age in Burkina Faso. Setting We used data from annual National Nutrition Surveys using Standardised Monitoring and Assessment of Relief and Transitions methodology (anthropometry, morbidity) over 7 years (2012-2018) in Burkina Faso. Participants Children of under 5 years from households selected through systemic sampling at countrywide level. Main outcome measures Prevalence of stunting (height-for-age z-score, \<-2), underweight (weight-for-age z-score, \<-2) and wasting (weight-for-height z-score, \<-2) at regional and national. We used general linear mixed models, adjusted by age, survey year, sex, presence of fever and/or diarrhoea, and poverty index to quantify the risk of undernutrition over time and by region of residence. Results Between 2012 and 2018, decreases were observed overall in the prevalence of growth retardation (stunting) decreased from 33.0% (95% CI 32.3 to 33.8) in 2012 to 26.7% (95% CI 26.2 to 27.3) in 2018. Underweight reduced from 24.4% (95% CI 23.7 to 25.1) to 18.7% (95% CI 18.2 to 19.2) for the same period and wasting decreased from 10.8% (95% CI 10.3 to 11.3) in 2012 to 8.4% (95% CI 8.1 to 8.8) in 2018. However, there was substantial variation across the country, with increased risk of undernutrition in the regions of Sahel, East and Cascades primarily. High-risk regions were characterised by a lower poverty index and limited access to healthcare services. Conclusions Our findings could inform national policymakers in refining and optimising resource allocation based on the identification of high-risk areas.},

keywords = {{Author(firstnames='Ad\'{e}la\"{i}de', Author(firstnames='Aminata', Author(firstnames='Caroline', Author(firstnames='Cornelius', Author(firstnames='Daniella', Author(firstnames='Doreen', Author(firstnames='Edith', Author(firstnames='Engelbert', Author(firstnames='Esmond W', Author(firstnames='James', Author(firstnames='Josephine', Author(firstnames='Kadija', Author(firstnames='Karim', Author(firstnames='Keith', Author(firstnames='Marie-Louise', Author(firstnames='Mark', Author(firstnames='Mary', Author(firstnames='Maxwell', Author(firstnames='Michael', Author(firstnames='Paul', Author(firstnames='Paula', Author(firstnames='Polly', Author(firstnames='Samuel', Author(firstnames='Sarah', Author(firstnames='Shane A', Author(firstnames='Stephanie', Author(firstnames='Winfred', Burkina Faso / epidemiology, Cachexia, Child, CollabAuthor(name='INPreP Study Group', Growth Disorders / epidemiology, Humans, Malnutrition* / epidemiology, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, Nutrition Surveys, Palwende Romuald Boua, PMC10496659, Preschool, PubMed Abstract, Research Support, Thinness* / epidemiology, Toussaint Rouamba},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Factors affecting African postdoctoral researcher capacity development within 'learn-by-doing' international research partnerships: findings from the 'Partnership for Increasing the Impact of Vector Control (PIIVeC)'},

author = {Jessica Amegee Quach and Innocent Valea and Imelda Bates and Justin Pulford},

url = {https://pubmed.ncbi.nlm.nih.gov/37678937/},

doi = {10.1136/BMJGH-2023-012626},

issn = {2059-7908},

year  = {2023},

date = {2023-01-01},

journal = {BMJ global health},

volume = {8},

issue = {9},

publisher = {BMJ Glob Health},

abstract = {Introduction The Partnership to Increase the Impact of Vector Control sought to develop the research and leadership capacity of 10 African postdoctoral vectorborne disease scientists via a € learn-by-doing' approach. We identified factors that either supported or hindered their development and, drawing on this information, determined key lessons for future programmes with similar objectives. Methods A longitudinal qualitative study encompassing focus group discussions and semistructured interviews conducted with the cohort of African postdoctoral fellows, programme leadership, supervisory and research support staff (N=28). Data analysis was informed by a general inductive approach. Results Numerous supportive and hindering factors were identified. Supportive factors were primarily structural or attitudinal in nature, whereas hindering factors were primarily operational or contextual. None of the supporting or hindering factors were specific to vectorborne disease research. Four key lessons for future programme implementation emerged, including: the value in exposing postdoctoral fellows to a diverse work-mix and training-mix to improve understanding of the broad skillset needed for scientific career advancement; recognising and managing the potentially competing interests of different partnership members to ensure everyone benefits from participation; ensuring equity of opportunity and rewarding engagement; and ensuring flexibility in support provision. Conclusion Our study highlights numerous factors that may be readily incorporated into early career researcher capacity strengthening initiatives based on a learn-by-doing approach. Many of these factors are supported by a growing weight of evidence and would be appropriate to research capacity strengthening programmes both within and outside of a vectorborne disease context.},

keywords = {doi:10.1136/bmjgh-2023-012626, Focus Groups, Health Personnel*, Humans, Innocent Valea, Jessica Amegee Quach, Justin Pulford, Leadership, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, Physicians*, PMC10496693, pmid:37678937, PubMed Abstract, Qualitative research, Research Support},

pubstate = {published},

tppubtype = {article}

}

@article{Ogutu2023,

title = {Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial},

author = {Bernhards Ogutu and Adoke Yeka and Sylvia Kusemererwa and Ricardo Thompson and Halidou Tinto and Andre Offianan Toure and Chirapong Uthaisin and Amar Verma and Afizi Kibuuka and Moussa Lingani and Carlos Louren\c{c}o and Ghyslain Mombo-Ngoma and Videlis Nduba and Tiacoh Landry N'Guessan and Gu\'{e}tawend\'{e} Job Wilfried Nassa and Mary Nyantaro and Lucas Otieno Tina and Piyoosh K. Singh and Myriam El Gaaloul and Anne Claire Marrast and Havana Chikoto and Katalin Csermak and Ivan Demin and Dheeraj Mehta and Rashidkhan Pathan and Celine Risterucci and Guoqin Su and Cornelis Winnips and Grace Kaguthi and Bakary Fofana and Martin Peter Grobusch},

url = {https://pubmed.ncbi.nlm.nih.gov/37327809/},

doi = {10.1016/S1473-3099(23)00209-8},

issn = {1474-4457},

year  = {2023},

date = {2023-01-01},

journal = {The Lancet. Infectious diseases},

volume = {23},

issue = {9},

pages = {1051-1061},

publisher = {Lancet Infect Dis},

abstract = {Background: Emergence of drug resistance demands novel antimalarial drugs with new mechanisms of action. We aimed to identify effective and well tolerated doses of ganaplacide plus lumefantrine solid dispersion formulation (SDF) in patients with uncomplicated Plasmodium falciparum malaria. Methods: This open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial was conducted at 13 research clinics and general hospitals in ten African and Asian countries. Patients had microscopically-confirmed uncomplicated P falciparum malaria (\>1000 and \<150 000 parasites per μL). Part A identified the optimal dose regimens in adults and adolescents (aged ≥12 years) and in part B, the selected doses were assessed in children (≥2 years and \<12 years). In part A, patients were randomly assigned to one of seven groups (once a day ganaplacide 400 mg plus lumefantrine-SDF 960 mg for 1, 2, or 3 days; ganaplacide 800 mg plus lumefantrine-SDF 960 mg as a single dose; once a day ganaplacide 200 mg plus lumefantrine-SDF 480 mg for 3 days; once a day ganaplacide 400 mg plus lumefantrine-SDF 480 mg for 3 days; or twice a day artemether plus lumefantrine for 3 days [control]), with stratification by country (2:2:2:2:2:2:1) using randomisation blocks of 13. In part B, patients were randomly assigned to one of four groups (once a day ganaplacide 400 mg plus lumefantrine-SDF 960 mg for 1, 2, or 3 days, or twice a day artemether plus lumefantrine for 3 days) with stratification by country and age (2 to \<6 years and 6 to \<12 years; 2:2:2:1) using randomisation blocks of seven. The primary efficacy endpoint was PCR-corrected adequate clinical and parasitological response at day 29, analysed in the per protocol set. The null hypothesis was that the response was 80% or lower, rejected when the lower limit of two-sided 95% CI was higher than 80%. This study is registered with EudraCT (2020\textendash003284\textendash25) and ClinicalTrials.gov (NCT03167242). Findings: Between Aug 2, 2017, and May 17, 2021, 1220 patients were screened and of those, 12 were included in the run-in cohort, 337 in part A, and 175 in part B. In part A, 337 adult or adolescent patients were randomly assigned, 326 completed the study, and 305 were included in the per protocol set. The lower limit of the 95% CI for PCR-corrected adequate clinical and parasitological response on day 29 was more than 80% for all treatment regimens in part A (46 of 50 patients [92%, 95% CI 81\textendash98] with 1 day, 47 of 48 [98%, 89\textendash100] with 2 days, and 42 of 43 [98%, 88\textendash100] with 3 days of ganaplacide 400 mg plus lumefantrine-SDF 960 mg; 45 of 48 [94%, 83\textendash99] with ganaplacide 800 mg plus lumefantrine-SDF 960 mg for 1 day; 47 of 47 [100%, 93\textendash100] with ganaplacide 200 mg plus lumefantrine-SDF 480 mg for 3 days; 44 of 44 [100%, 92\textendash100] with ganaplacide 400 mg plus lumefantrine-SDF 480 mg for 3 days; and 25 of 25 [100%, 86\textendash100] with artemether plus lumefantrine). In part B, 351 children were screened, 175 randomly assigned (ganaplacide 400 mg plus lumefantrine-SDF 960 mg once a day for 1, 2, or 3 days), and 171 completed the study. Only the 3-day regimen met the prespecified primary endpoint in paediatric patients (38 of 40 patients [95%, 95% CI 83\textendash99] vs 21 of 22 [96%, 77\textendash100] with artemether plus lumefantrine). The most common adverse events were headache (in seven [14%] of 51 to 15 [28%] of 54 in the ganaplacide plus lumefantrine-SDF groups and five [19%] of 27 in the artemether plus lumefantrine group) in part A, and malaria (in 12 [27%] of 45 to 23 [44%] of 52 in the ganaplacide plus lumefantrine-SDF groups and 12 [50%] of 24 in the artemether plus lumefantrine group) in part B. No patients died during the study. Interpretation: Ganaplacide plus lumefantrine-SDF was effective and well tolerated in patients, especially adults and adolescents, with uncomplicated P falciparum malaria. Ganaplacide 400 mg plus lumefantrine-SDF 960 mg once daily for 3 days was identified as the optimal treatment regimen for adults, adolescents, and children. This combination is being evaluated further in a phase 2 trial (NCT04546633). Funding: Novartis and Medicines for Malaria Venture.},

keywords = {Adoke Yeka, Adolescent, Adult, Antimalarials*, Artemether / pharmacology, Artemether / therapeutic use, Artemisinins*, Bernhards Ogutu, Child, Clinical Trial, doi:10.1016/S1473-3099(23)00209-8, Drug Combinations, Ethanolamines / pharmacology, Ethanolamines / therapeutic use, Falciparum* / drug therapy, Falciparum* / parasitology, Fluorenes / pharmacology, Fluorenes / therapeutic use, Humans, Lumefantrine / pharmacology, Lumefantrine / therapeutic use, Malaria, Malaria* / drug therapy, Martin Peter Grobusch, MEDLINE, Multicenter Study, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, Phase II, Plasmodium falciparum, pmid:37327809, PubMed Abstract, Randomized controlled trial, Research Support, Treatment Outcome},

pubstate = {published},

tppubtype = {article}

}

@article{Nag2023,

title = {Whole genomes from bacteria collected at diagnostic units around the world 2020},

author = {Sidsel Nag and Gunhild Larsen and Judit Szarvas and Laura Elmlund Kohl Birkedahl and G\'{a}bor M\'{a}t\'{e} Guly\'{a}s and Wojchiech Jakub Ciok and Timmie Mikkel Lagermann and Silva Tafaj and Susan Bradbury and Peter Collignon and Denise Daley and Victorien Dougnon and Kafayath Fabiyi and Boubacar Coulibaly and Ren\'{e} Demb\'{e}l\'{e} and Georgette Nikiema and Natama Magloire and Isidore Juste Ouindgueta and Zenat Zebin Hossain and Anowara Begum and Deyan Donchev and Mathew Diggle and Lee Ann Turnbull and Simon L\'{e}vesque and Livia Berlinger and Kirstine Kobberoe Sogaard and Paula Diaz Guevara and Carolina Duarte Valderrama and Panagiota Maikanti and Jana Amlerova and Pavel Drevinek and Jan Tkadlec and Milica Dilas and Achim Kaasch and Henrik Torkil Westh and Mohamed Azzedine Bachtarzi and Wahiba Amhis and Carolina Elisabeth Sat\'{a}n Salazar and Jos\'{e}Eduardo E. Villacis and M\'{a}ria Angeles Dominguez L\'{u}zon and D\'{a}maris Berbel Palau and Claire Duployez and Maxime Paluche and Solomon Asante-Sefa and Mie Moller and Margaret Ip and Ivana Marekovi\'{c} and Agnes P\'{a}l-Sonnevend and Clementiza Elvezia Cocuzza and Asta Dambrauskiene and Alexandre Macanze and Anelsio Cossa and In\'{a}cio Mandomando and Philip Nwajiobi-Princewill and Iruka N. Okeke and Aderemi O. Kehinde and Ini Adebiyi and Ifeoluwa Akintayo and Oluwafemi Popoola and Anthony Onipede and Anita Blomfeldt and Nora Elisabeth Nyquist and Kiri Bocker and James Ussher and Amjad Ali and Nimat Ullah and Habibullah Khan and Natalie Weiler Gustafson and Ikhlas Jarrar and Arif Al-Hamad and Viravarn Luvira and Wantana Paveenkittiporn and Irmak Baran and James C. L. Mwansa and Linda Sikakwa and Kaunda Yamba and Rene Sjogren Hendriksen and Frank Moller Aarestrup},

url = {https://pubmed.ncbi.nlm.nih.gov/37717051/},

doi = {10.1038/S41597-023-02502-7},

issn = {2052-4463},

year  = {2023},

date = {2023-01-01},

journal = {Scientific data},

volume = {10},

issue = {1},

publisher = {Sci Data},

abstract = {The Two Weeks in the World research project has resulted in a dataset of 3087 clinically relevant bacterial genomes with pertaining metadata, collected from 59 diagnostic units in 35 countries around the world during 2020. A relational database is available with metadata and summary data from selected bioinformatic analysis, such as species prediction and identification of acquired resistance genes.},

keywords = {Bacteria* / genetics, Bacterial*, Computational Biology, Databases, Dataset, doi:10.1038/s41597-023-02502-7, Factual, Frank Moller Aarestrup, Genome, Gunhild Larsen, MEDLINE, Metadata, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, PMC10505216, pmid:37717051, PubMed Abstract, Sidsel Nag},

pubstate = {published},

tppubtype = {article}

}

@article{Djimde2023,

title = {Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial},

author = {Moussa Djimde and Japhet Kabalu Tshiongo and Hypolite Mavoko Muhindo and Halidou Tinto and Esperanca Sevene and Maminata Traore and Anifa Vala and Salesio MacUacua and Berenger Kabore and Edgard Diniba Dabira and Annette Erhart and Hamadoun Diakite and Mohamed Keita and Mireia Piqueras and Raquel Gonz\'{a}lez and Clara Menendez and Thomas P. C. Dorlo and Issaka Sagara and Petra Mens and Henk Schallig and Umberto D'Alessandro and Kassoum Kayentao},

url = {https://pubmed.ncbi.nlm.nih.gov/37813539/},

doi = {10.1136/BMJOPEN-2022-065295},

issn = {2044-6055},

year  = {2023},

date = {2023-01-01},

journal = {BMJ open},

volume = {13},

issue = {10},

publisher = {BMJ Open},

abstract = {Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP. Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4-6 weeks after delivery, and infants' health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population. Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings. Trial registration number PACTR202011812241529.},

keywords = {Antimalarials* / adverse effects, Artemether, Artemether / therapeutic use, Artemisinins* / adverse effects, Clinical Trial Protocol, Clinical Trials, doi:10.1136/bmjopen-2022-065295, Drug Combinations, Falciparum* / drug therapy, Female, Humans, Infant, Japhet Kabalu Tshiongo, Kassoum Kayentao, Lumefantrine Drug Combination / therapeutic use, Malaria, Malaria* / drug therapy, MEDLINE, Moussa Djimde, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Non-U.S. Gov't, Phase III as Topic, PMC10565244, pmid:37813539, Pregnancy, Pregnant Women, PubMed Abstract, Randomized Controlled Trials as Topic, Research Support, Sub-Saharan African People, Treatment Outcome},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Performance of ultra-sensitive malaria rapid diagnostic test to detect Plasmodium falciparum infection in pregnant women in Kinshasa, the Democratic Republic of the Congo},

author = {Japhet Kabalu Tshiongo and Flory Luzolo and Melissa Kabena and Lise Kuseke and Moussa Djimde and Patrick Mitashi and Crispin Lumbala and Kassoum Kayentao and Sandra Menting and Petra F. Mens and Henk D. F. H. Schallig and Pascal Lutumba and Halidou Tinto and Hypolite Muhindo Mavoko and Vivi Maketa},

url = {https://pubmed.ncbi.nlm.nih.gov/37872634/},

doi = {10.1186/S12936-023-04749-2},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: Low peripheral parasitaemia caused by sequestration of Plasmodium falciparum in the placenta hampers the diagnosis of malaria in pregnant women, leading to microscopy or conventional rapid diagnostic tests (RDTs) false-negative results. Although mainly asymptomatic, maternal malaria remains harmful to pregnant women and their offspring in endemic settings and must be adequately diagnosed. Ultra-sensitive RDTs (uRDTs) are thought to be more sensitive than RDTs, and their diagnostic performance was assessed in the current study in pregnant women living in Kinshasa, a stable malaria transmission area in the Democratic Republic of the Congo. Methods: To assess and compare the diagnostic performances of both RDTs and uRDTs, 497 peripheral blood samples were tested using microscopy and quantitative polymerase chain reaction (qPCR) as the index and the reference tests, respectively. The agreement between the different diagnostic tests assessed was estimated by Cohen's Kappa test. Results: The median parasite density by qPCR was 292 p/μL of blood [IQR (49.7\textendash1137)]. Using qPCR as the reference diagnostic test, the sensitivities of microscopy, RDT and uRDT were respectively [55.7% (95% CI 47.6\textendash63.6)], [81.7% (95%CI 74.7\textendash87.3)] and [88% (95% CI 81.9\textendash92.6)]. The specificities of the tests were calculated at 98.5% (95% CI 96.6\textendash99.5), 95.2% (95% CI 92.5\textendash97.2) and 94.4% (95% CI 91.4\textendash96.6) for microscopy, RDT and uRDT, respectively. The agreement between qPCR and uRDT was almost perfect (Kappa = 0.82). For parasite density (qPCR) below 100 p/µL, the sensitivity of RDT was 62% (95% CI 47.1\textendash75.3) compared to 68% (95% CI 53.3\textendash80.4) for uRDT. Between 100 and 200 p/µL, the sensitivity of RDT was higher, but still lower compared to uRDT: 89.4% (95% CI 66.8\textendash98.7) for RDT versus 100% (95% CI 82.3\textendash100) for uRDT. In both cases, microscopy was lower, with 20% (95% CI 10\textendash33.7) and 47.3% (95% CI 24.4\textendash71.1) respectively. Conclusions: uRDT has the potential to improve malaria management in pregnant women as it has been found to be slightly more sensitive than RDT in the detection of malaria in pregnant women but the difference was not significant. Microscopy has a more limited value for the diagnosis of malaria during the pregnancy, because of its lower sensitivity.},

keywords = {Antigens, Democratic Republic of the Congo, Diagnostic Tests, doi:10.1186/s12936-023-04749-2, Falciparum* / epidemiology, Female, Flory Luzolo, Humans, Japhet Kabalu Tshiongo, Malaria, Malaria*, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Plasmodium falciparum, PMC10594769, pmid:37872634, Pregnancy, Pregnant Women, Protozoan, PubMed Abstract, Rapid diagnostic tests, Routine / methods, Sensitivity and Specificity, Vivi Maketa},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Revisiting How Exclusive is Exclusive Breastfeeding Practice as Determined by the Deuterium Dose-to-mother Technique: A Comparison of Methods of Assessment},

author = {Coulibaly Nadine Mireille Josepha Danielle and Somda Manutuo Aymard Serges and Sawadogo Amad\'{e} and Compaor\'{e} Yves Daniel and Sorgho Hermann and Yerbanga Rakiswend\'{e} Serges and Ouedraogo C\'{e}saire Tania and Zeba Augustin Nawidimbasba and Ouedraogo Jean-Bosco and Ouedraogo Cesaire Tania},

url = {https://pubs.sciepub.com/jfnr/11/11/1/index.html https://pubs.sciepub.com/jfnr/11/11/1/abstract.html},

doi = {10.12691/JFNR-11-11-1},

issn = {2333-1119},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Food and Nutrition Research, Vol. 11, 2023, Pages 667-671},

volume = {11},

issue = {11},

pages = {667-671},

publisher = {Science and Education Publishing},

abstract = {Exclusive breastfeeding (EBF) for the first 6 months is recommended by WHO and UNICEF as feeding practice in early infancy. This implies the choice of a robust method to ascertain that the mothers have really observed the recommendation. By analyzing secondary data from a breastfeeding study we conducted in Burkina Faso, we aimed to determine the accuracy of different ways to assess EBF. We examined EBF practice through maternal reports of 24 hours (24h recall) and the deuterium oxide dose-to-mother technique (DMT) cross-sectional and longitudinal measurements. We also used the DMT data to simulate the WHO indicator of EBF by cumulating the assessments from birth to 5 months. Then the different methods were compared using the McNemar test. The results showed that globally, the maternal report overestimated the EBF rate compared to the DMT with a difference of 19.17% (95% CI=11.29%-27.04%},

keywords = {cross, dose, exclusive breastfeeding, longitudinal assessment, maternal report, McNemar test, mother technique, sectional measurement, to},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {A Bayesian spatio-temporal framework to assess the effect of seasonal malaria chemoprevention on children under 5 years in Cameroon from 2016 to 2021 using routine data},

author = {Arnold Fottsoh Fokam and Toussaint Rouamba and Sekou Samadoulougou and Yazoume Ye and Fati Kirakoya-Samadoulougou},

url = {https://pubmed.ncbi.nlm.nih.gov/37951942/},

doi = {10.1186/S12936-023-04677-1},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: Malaria affects millions of Cameroonian children under 5 years of age living in the North and Far North regions. These regions bear the greatest burden, particularly for children under 5 years of age. To reduce the burden of disease in these regions, Cameroon adopted the Seasonal Malaria Chemoprevention (SMC) in 2016 and has implemented it each year since its adoption. However, no previous studies have systematically assessed the effects of this intervention in Cameroon. It is important to understand its effect and whether its implementation could be improved. This study aimed to assess the effect of SMC in Cameroon during the period 2016\textendash2021 on malaria morbidity in children under 5 years of age using routine data. Methods: Data on malaria cases were extracted from the Cameroon Health Monitoring Information System (HMIS) from January 1, 2011, to December 31, 2021. Health facilities report these data monthly on a single platform, the District Health Information System version 2 (DHIS2). Thus, a controlled interrupted time-series model in a Bayesian framework was used to evaluate the effects of the SMC on malaria morbidity. Results: SMC implementation was associated with a reduction in the incidence of uncomplicated malaria cases during the high-transmission periods from 2016 to 2021. Regarding the incidence of severe malaria during the high-transmission period, a reduction was found over the period 2016\textendash2019. The highest reduction was registered during the second year of implementation in 2017:15% (95% Credible Interval, 10\textendash19) of uncomplicated malaria cases and 51% (47\textendash54) of confirmed severe malaria cases. Conclusion: The addition of SMC to the malaria intervention package in Cameroon decreased the incidence of uncomplicated and severe malaria among children under 5 years of age. Based on these findings, this study supports the wide implementation of SMC to reduce the malaria burden in Cameroon as well as the use of routine malaria data to monitor the efficiency of the strategy in a timely manner.},

keywords = {Antimalarials* / therapeutic use, Arnold Fottsoh Fokam, Bayes Theorem, Cameroon / epidemiology, Chemoprevention, Child, doi:10.1186/s12936-023-04677-1, Fati Kirakoya-Samadoulougou, Humans, Infant, Malaria* / drug therapy, Malaria* / epidemiology, Malaria* / prevention \& control, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, PMC10640753, pmid:37951942, Preschool, PubMed Abstract, Seasons, Toussaint Rouamba},

pubstate = {published},

tppubtype = {article}

}

@article{Yerbanga2023,

title = {Performances of disk diffusion method for determining triazole susceptibility of Aspergillus species: Systematic review},

author = {Isidore W. Yerbanga and Seydou Nakanabo Diallo and Toussaint Rouamba and Agustin Resendiz-Sharpe and Katrien Lagrou and Olivier Denis and Hector Rodriguez-Villalobos and Isabel Montesinos and Sanata Bamba},

url = {https://pubmed.ncbi.nlm.nih.gov/37603962/},

doi = {10.1016/J.MYCMED.2023.101413},

issn = {1773-0449},

year  = {2023},

date = {2023-01-01},

journal = {Journal de mycologie medicale},

volume = {33},

issue = {4},

publisher = {J Mycol Med},

abstract = {The therapeutic management of invasive aspergillosis should be guided by antifungal susceptibility testing (AFST). The disk diffusion (DD) method due to its simplicity and low cost could be an appropriate alternative to the reference methods (CLSI, EUCAST) which are not suitable for AFST in routine clinical microbiology laboratories, particularly in resource-constrained settings. This review summarizes the available data on the performance of the DD method in determining triazole susceptibility profile of Aspergillus species. The published articles on the performance of DD method for determining triazole susceptibility of Aspergillus spp. were systematically searched on major medical databases and Google Scholar. We identified 2725 articles of which 13 met the inclusion criteria. The overall average agreement value obtained between DD and CLSI broth microdilution (CLSI-BMD) methods for the itraconazole 10 µg disk (70.75%) was low especially when the medium used was not Mueller-Hinton (MH) agar. In contrast average agreement for the voriconazole 1 µg disk and the posaconazole 5 µg disk were \> 94% regardless of media used. The correlation coefficient values between the DD and CLSI-BMD methods on MH agar were acceptable (≥ 0.71) for the itraconazole 10 µg disk and posaconazole 5 µg disk and good (≥ 0.80) for the voriconazole 1 and 10 µg disk. The reproducibility of the DD method regardless to the medium used was ≥ 82%. This systematic review shows that the disk diffusion method could be a real alternative for triazole antifungals susceptibility testing of Aspergillus spp.},

keywords = {Agar, Antifungal Agents* / pharmacology, Aspergillus, doi:10.1016/j.mycmed.2023.101413, Isidore W Yerbanga, Itraconazole* / pharmacology, MEDLINE, Microbial Sensitivity Tests, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, pmid:37603962, PubMed Abstract, Reproducibility of Results, Review, Sanata Bamba, Seydou Nakanabo Diallo, Systematic review, Triazoles / pharmacology, Voriconazole / pharmacology},

pubstate = {published},

tppubtype = {article}

}

@article{Ouedraogo2023,

title = {The burden of the coronavirus disease 2019 virus infection in Burkina Faso: Results from a World Health Organization UNITY population-based, age-stratified sero-epidemiological investigation},

author = {Samiratou Ouedraogo and Isidore Tiandiogo Traor\'{e} and Dramane Kania and Nongodo Firmin Kabor\'{e} and Ariane Mamguem Kamga and Hermann Badolo and Mimbour\'{e} Yara and Guillaume Sanou and Amariane Kon\'{e} and Samdapawind\'{e} Th\'{e}r\`{e}se Kagon\'{e} and Esperance Ou\'{e}draogo and Blahima Konat\'{e} and Rachel M\'{e}dah and Nathalie Rekeneire and Armel Poda and Arnaud Eric Diendere and Boukary Ou\'{e}draogo and Oumar Billa and Gilles Paradis and Halidou Tinto and Tienhan Sandrine Dabakuyo-Yonli},

url = {https://pubmed.ncbi.nlm.nih.gov/38019697/},

doi = {10.1111/IRV.13216},

issn = {1750-2659},

year  = {2023},

date = {2023-01-01},

journal = {Influenza and other respiratory viruses},

volume = {17},

issue = {11},

publisher = {Influenza Other Respir Viruses},

abstract = {Background: This study aimed to estimate the anti-SARS-CoV-2 antibody seroprevalence in the general population of Bobo-Dioulasso and Ouagadougou (Burkina Faso). Methods: We collected from March to April 2021 blood samples from randomly selected residents in both main cities based on the World Health Organization (WHO) sero-epidemiological investigations protocols and tested them with WANTAI SARS-CoV-2 total antibodies enzyme-linked immunosorbent assay (ELISA) kits intended for qualitative assessment. We also recorded participants' socio-demographic and clinical characteristics and information on exposure to SARS-CoV-2. Data were analysed with descriptive and comparative statistics. Results: We tested 5240 blood samples collected between 03 March and 16 April 2021. The overall test-adjusted seroprevalence for SARS-CoV-2 antibodies was (67.8% [95% CI 65.9\textendash70.2]) (N = 3553/3982). Seroprevalence was highest among participants aged 15\textendash18 years old (74.2% [95% CI 70.5\textendash77.5]) (N = 465/627), compared with those aged 10\textendash14 years old (62.6% [95% CI 58.7\textendash66.4]) (N = 395/631), or those over 18 (67.6% [95% CI 66.2\textendash69.1]) (N = 2693/3982). Approximately 71.0% (601/860) of participants aged 10\textendash18 years old who tested positive for SARS-CoV-2 antibodies experienced no clinical COVID-19 symptoms in the weeks before the survey, compared with 39.3% (1059/2693) among those aged over 18 years old. Conclusion: This study reports the results of the first known large serological survey in the general population of Burkina Faso. It shows high circulation of SARS-CoV-2 in the two cities and a high proportion of asymptomatic adolescents. Further studies are needed to identify the SARS-CoV-2 variants and to elucidate the factors protecting some infected individuals from developing clinical COVID-19.},

keywords = {Adolescent, Adult, Antibodies, Burkina Faso / epidemiology, Child, COVID-19* / epidemiology, doi:10.1111/irv.13216, Humans, Isidore Tiandiogo Traor\'{e}, MEDLINE, Middle Aged, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, PMC10655778, pmid:38019697, PubMed Abstract, Samiratou Ou\'{e}draogo, SARS-CoV-2*, Seroepidemiologic Studies, Surveys and Questionnaires, Tienhan Sandrine Dabakuyo-Yonli, Viral},

pubstate = {published},

tppubtype = {article}

}

@article{Singh2023,

title = {Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study},

author = {Surina Singh and Ananyo Choudhury and Scott Hazelhurst and Nigel Crowther and Palwende Boua and Hermann Sorgho and Godfred Agongo and Engelbert Nonterah and Lisa Micklesfield and Shane Norris and Isaac Kisiangani and Shukri Mohamed and Francesc Gomez-Olive and Stephen Tollman and Solomon Choma and Jean-Tristan Brandenburg and Michele Ramsay},

url = {https://pubmed.ncbi.nlm.nih.gov/36824767/ http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9949264},

doi = {10.21203/RS.3.RS-2532794/V1},

issn = {2693-5015},

year  = {2023},

date = {2023-01-01},

journal = {Research square},

publisher = {Res Sq},

abstract = {Most hypertension-related genome-wide association studies (GWAS) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure-related traits (systolic and diastolic blood pressure, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N=10,775), identified two genome-wide significant signals (p\<5E-08): systolic blood pressure near P2RY1 (rs77846204; intergenic variant},

keywords = {Ananyo Choudhury, doi:10.21203/rs.3.rs-2532794/v1, MEDLINE, Mich\`{e}le Ramsay, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, PMC9949264, pmid:36824767, Preprint, PubMed Abstract, Surina Singh},

pubstate = {published},

tppubtype = {article}

}

@article{Lingani2023,

title = {Coinfections with SARS-CoV-2 variants and influenza virus during the 2019 Coronavirus disease pandemic in Burkina Faso: A surveillance study},

author = {Moussa Lingani and Assana Ciss\'{e} and Dieudonn\'{e} Tialla and Abdoul Kader Ilboudo and Madi Savadogo and Catherine Sawadogo and Sandrine Gampini and Grissoum Tarnagda and Maria Tao and Serge Diagbouga and Sanata Bamba and Zekiba Tarnagda},

doi = {10.1002/hsr2.1041},

issn = {23988835},

year  = {2023},

date = {2023-01-01},

journal = {Health Science Reports},

volume = {6},

issue = {1},

abstract = {Background and Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particularly the variants of concern coinfections with influenza is a public health concern in Africa. We aimed to characterize the SARS-CoV-2 variants and determine the rate of coinfections with influenza in Burkina Faso. Methods: COVID-19 surveillance study was conducted between August 2021 and January 2022 using reverse transcription polymerase chain reaction (RT-PCR). Positive specimens were further screened for SARS-CoV-2 variants using the multiple variants real-time PCR kits. In addition, influenza virus strains were detected by RT-PCR in SARS-CoV-2 positive specimens using the CDC primers, probes, and protocols. Results: Of 324 specimens assessed, the Omicron and Delta variants of SARS-CoV-2 were the most prevalent with 27.2% [95% confident interval (CI): 22.5\textendash32.4] and 22.2% [95% CI: 17.9\textendash27.2], respectively. The Beta and Gamma variants were detected in 4.3% [95% CI: 2.4\textendash7.1] and 0.3% [95% CI: 0.0\textendash1.7], respectively. Coinfections of Omicron and Beta variants were reported in 21.3% [95% CI: 17.0\textendash26.2], Omicron and Delta variants in 1.2% [95% CI: 0.3\textendash3.1] of specimens, and the Omicron\textendashGamma variants' coinfections in 0.6% [95% CI: 0.1\textendash2.2]. One COVID-19 specimen with an undetected SARS-CoV-2 variant was also tested positive for the seasonal influenza A (H3N2) virus. No cases of pandemic influenza A (H1N1)pdm09, seasonal A/H1N1, and influenza B were detected. Conclusions: The current World Health Organization SARS-CoV-2 variants of concern were prevalent and their coinfections with influenza were uncommon. Continuous surveillance of both pathogens is, however, needed because of their public health implications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.},

author = {Ananyo Choudhury and Jean-Tristan Brandenburg and Tinashe Chikowore and Dhriti Sengupta and Palwende Romuald Boua and Nigel J. Crowther and Godfred Agongo and Gershim Asiki and F. Xavier G\'{o}mez-Oliv\'{e} and Isaac Kisiangani and Eric Maimela and Matshane Masemola-Maphutha and Lisa K. Micklesfield and Engelbert A. Nonterah and Shane A. Norris and Hermann Sorgho and Halidou Tinto and Stephen Tollman and Sarah E. Graham and Cristen J. Willer and Scott Hazelhurst and Mich\`{e}le Ramsay},

doi = {10.1038/s41467-022-30098-w},

year  = {2022},

date = {2022-05-01},

urldate = {2022-05-01},

journal = {Nature communications},

volume = {13},

issue = {1},

pages = {2578},

abstract = {Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in the GATB region (P-value=1.56 × 10(-8)). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with the GATB/FHIP1A region and identifies a novel triglyceride association signal close to the FHIT gene (P-value =2.66 × 10(-8)). Our data enable fine-mapping of several well-known lipid-trait loci including LDLR, PMFBP1 and LPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data.},

keywords = {*Genome-Wide Association Study, Africa South of the Sahara, Cholesterol, Cross-Sectional Studies, Humans, LDL/genetics},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection.},

author = {D\'{i}dac Maci\`{a} and Joseph J. Campo and Gemma Moncunill and Chenjerai Jairoce and Augusto J. Nhabomba and Maximilian Mpina and Hermann Sorgho and David Dosoo and Ousmane Traore and Kwadwo Asamoah Kusi and Nana Aba Williams and Amit Oberai and Arlo Randall and H\`{e}ctor Sanz and Clarissa Valim and Kwaku Poku Asante and Seth Owusu-Agyei and Halidou Tinto and Selidji Todagbe Agnandji and Simon Kariuki and Ben Gyan and Claudia Daubenberger and Benjamin Mordm\"{u}ller and Paula Petrone and Carlota Doba\~{n}o},

doi = {10.1172/jci.insight.158030},

issn = {2379-3708},

year  = {2022},

date = {2022-05-01},

urldate = {2022-05-01},

journal = {JCI insight},

volume = {7},

issue = {10},

abstract = {The RTS,S/AS01E vaccine targets the circumsporozoite protein (CSP) of the Plasmodium falciparum (P. falciparum) parasite. Protein microarrays were used to measure levels of IgG against 1000 P. falciparum antigens in 2138 infants (age 6-12 weeks) and children (age 5-17 months) from 6 African sites of the phase III trial, sampled before and at 4 longitudinal visits after vaccination. One month postvaccination, IgG responses to 17% of all probed antigens showed differences between RTS,S/AS01E and comparator vaccination groups, whereas no prevaccination differences were found. A small subset of antigens presented IgG levels reaching 4- to 8-fold increases in the RTS,S/AS01E group, comparable in magnitude to anti-CSP IgG levels (~11-fold increase). They were strongly cross-correlated and correlated with anti-CSP levels, waning similarly over time and reincreasing with the booster dose. Such an intriguing phenomenon may be due to cross-reactivity of anti-CSP antibodies with these antigens. RTS,S/AS01E vaccinees with strong off-target IgG responses had an estimated lower clinical malaria incidence after adjusting for age group, site, and postvaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but also to unrelated malaria antigens, and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.},

keywords = {*Adaptive immunity, *Antigen, *Epidemiology, *Immunology, *Infectious disease, *Malaria, *Malaria Vaccines, *Malaria/prevention \& control, Antibodies, Antigens, Child, Falciparum/prevention \& control, Humans, Immunoglobulin G, Infant, Protozoan, Vaccination},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Changing Dietary Habits: The Impact of Urbanization and Rising Socio-Economic Status in Families from Burkina Faso in Sub-Saharan Africa.},

author = {Silene Casari and Monica Di Paola and Elena Banci and Salou Diallo and Luca Scarallo and Sara Renzo and Agnese Gori and Sonia Renzi and Monica Paci and Quirijn Mast and Tal Pecht and Karim Derra and Berenger Kabor\'{e} and Halidou Tinto and Duccio Cavalieri and Paolo Lionetti},

doi = {10.3390/nu14091782},

issn = {2072-6643},

year  = {2022},

date = {2022-04-01},

urldate = {2022-04-01},

journal = {Nutrients},

volume = {14},

issue = {9},

abstract = {(1) Background: Sub-Saharan Africa is experiencing the fastest urbanization worldwide. People in rural areas still have a traditional and rural lifestyle, whereas the Westernization of diet and lifestyle is already evident in urban areas. This study describes dietary habits of families in Burkina Faso living at different levels of urbanization. (2) Methods: Data on lifestyle, socio-economic conditions, health status and anthropometry were collected from 30 families living in rural villages, a small town and the capital city. A food frequency questionnaire and a 24 h recall diary were used to estimate dietary habits and macronutrients intake. (3) Results: The urban cohort showed a more diversified diet, with a higher intake of animal protein and, especially in children, a higher consumption of simple sugars. Fiber intake was significantly higher in the rural and semi-urbanized cohorts. As expected, overweight and obesity gradually increased with the level of urbanization. In semi-urbanized and urban families, we observed coexistence of under- and over-nutrition, whereas in rural families, a portion of children were wasted and stunted, and adults were underweight. (4) Conclusions: These three cohorts represent a model of the effect on diet of rural-to-urban migration. Rural diet and traditional habits are replaced by a Western-oriented diet when families move to urbanized areas. This dietary transition and increased socio-economic status in newly developing urban areas have a major impact on disease epidemiology, resembling the past evolution in Western countries.},

keywords = {*Economic Status, *Urbanization, Burkina Faso, Burkina Faso/epidemiology, Feeding Behavior, fiber intake, Humans, rural diet, Rural Population, sub-Saharan Africa, Urban Population, urbanization, Western diet},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Age-modified factors associated with placental malaria in rural Burkina Faso.},

author = {Bi\'{e}bo Bihoun and Serge Henri Zango and Maminata Traor\'{e}-Coulibaly and Innocent Valea and Raffaella Ravinetto and Jean Pierre Van Geertruyden and Umberto D'Alessandro and Halidou Tinto and Annie Robert},

doi = {10.1186/s12884-022-04568-4},

issn = {1471-2393},

year  = {2022},

date = {2022-03-01},

urldate = {2022-03-01},

journal = {BMC pregnancy and childbirth},

volume = {22},

issue = {1},

pages = {248},

abstract = {BACKGROUND: Malaria in pregnancy can result in placental infection with fetal implications. This study aimed at assessing placental malaria (PM) prevalence and its associated factors in a cohort of pregnant women with peripheral malaria and their offspring. METHOD: The data were collected in the framework of a clinical trial on treatments for malaria in pregnant women . Placental malaria (PM) was diagnosed by histopathological detection of parasites and/or malaria pigment on placenta biopsies taken at delivery. Factors associated with PM were assessed using logistic regression. RESULTS: Out of 745 biopsies examined, PM was diagnosed in 86.8 % of women. Acute, chronic and past PM were retrieved in 11 (1.5 %), 170 (22.8 %), and 466 (62.6 %) women, respectively. A modifying effect was observed in the association of gravidity or anemia at the study start with pooled PM (presence of parasites and/or malaria pigment). In women under 30, gravidity ≤ 2 was associated with an increased prevalence of pooled PM but in women aged 30 years or more, gravidity was no more associated with pooled PM (OR 6.81, 95 % CI 3.18 - 14.60; and OR 0.52, 95 % CI 0.10 - 2.76, respectively). Anemia was associated with pooled PM in women under 30 (OR 1.96, 95 % CI 1.03 - 3.72) but not in women aged 30 years or more (OR 0.68, 95 % CI 0.31 - 1.49). Similarly, the association of gravidity with past-chronic PM depended also on age. A higher prevalence of active PM was observed in women under 30 presenting with symptomatic malaria (OR 3.79, 95 % CI 1.55 - 9.27), while there was no significant increase in the prevalence of active PM (presence of parasites only) in women with symptomatic malaria when aged 30 years or more (OR 0.42, 95 % CI 0.10 - 1.75). In women with chronic PM, the prevalence of low birth weight or prematurity was the highest (31.2 %) as compared with past PM or no PM. CONCLUSION: Despite the rapid diagnosis and efficacious treatment of peripheral infection, the prevalence of placental malaria remained high in women with P. falciparum peripheral infection in Nanoro, especially in younger women This underlines the importance of preventive measures in this specific group.},

keywords = {*Malaria, *Malaria/epidemiology, Adult, Burkina Faso, Burkina Faso/epidemiology, Falciparum/parasitology, Female, Gravidity, Humans, Malaria, placenta, Placenta/parasitology, Pregnancy, Risk Factors},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Low birth weight and its associated risk factors in a rural health district of Burkina Faso: a cross sectional study.},

author = {Moussa Lingani and Serge Henri Zango and Innocent Val\'{e}a and Georges Som\'{e} and Ma\"{i}mouna Sanou and S\'{e}kou O. Samadoulougou and Serge Ouoba and Eli Rouamba and Annie Robert and Mich\`{e}le Dramaix and Philippe Donnen and Halidou Tinto},

doi = {10.1186/s12884-022-04554-w},

issn = {1471-2393},

year  = {2022},

date = {2022-03-01},

urldate = {2022-03-01},

journal = {BMC pregnancy and childbirth},

volume = {22},

issue = {1},

pages = {228},

abstract = {BACKGROUND: Low birth weight (LBW) is a major factor of neonate mortality that particularly affects developing countries. However, the scarcity of data to support decision making to reduce LBW occurrence is a major obstacle in sub-Saharan Africa. The aim of this research was to determine the prevalence and associated factors of LBW at the Yako health district in a rural area of Burkina Faso. METHODS: A cross sectional survey was conducted at four peripheral health centers among mothers and their newly delivered babies. The mothers' socio-demographic and obstetrical characteristics were collected by face-to-face interview or by review of antenatal care books. Maternal malaria was tested by standard microscopy and neonates' birth weights were documented. Multivariate logistic regression was used to determine factors associated with LBW. A p-value \< 0.05 was considered statistically significant. RESULTS: Of 600 neonates examined, the prevalence of low birth weight was 11.0%. Adjustment for socio-demographic characteristic, medical conditions, obstetrical history, malaria prevention measures by multivariate logistic regression found that being a primigravid mother (aOR = 1.8, [95% CI: 1.1-3.0]), the presence of malaria infection (aOR = 1.9, [95% CI: 1.1-3.5]), the uptake of less than three doses of sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy (IPTp-SP) (aOR = 2.2, [95% CI: 1.3-3.9]), the presence of maternal fever at the time of delivery (aOR = 2.8, [95% CI: 1.5-5.3]) and being a female neonate (aOR = 1.9, [95% CI: 1.1-3.3]) were independently associated with an increased risk of LBW occurrence. The number of antenatal visits performed by the mother during her pregnancy did not provide any direct protection for low birth weight. CONCLUSION: The prevalence of LBW remained high in the study area. Maternal malaria, fever and low uptake of sulfadoxine-pyrimethamine doses were significantly associated with LBW and should be adequately addressed by public health interventions.},

keywords = {*Antimalarials/therapeutic use, *Rural Health, Associated factors, Burkina Faso, Burkina Faso/epidemiology, Cross-Sectional Studies, Female, Humans, Infant, Low Birth Weight, Newborn, Pregnancy, Risk Factors, Rural area},

pubstate = {published},

tppubtype = {article}

}

@article{Chen2022,

title = {Novel direct growth of ZIF-67 derived Co(3)O(4) and N-doped carbon composites on carbon cloth as supercapacitor electrodes.},

author = {Tzu-Yang Chen and Tsung-Rong Kuo and Sibidou Yougbar\'{e} and Lu-Yin Lin and Cheng-Yu Xiao},

doi = {10.1016/j.jcis.2021.09.198},

year  = {2022},

date = {2022-02-01},

urldate = {2022-02-01},

journal = {Journal of colloid and interface science},

volume = {608},

issue = {Pt 1},

pages = {493-503},

address = {United States},

abstract = {Zeolitic imidazolate framework-67 (ZIF67) derivatives are considered as promising active materials for energy storage owing to the possible formation of cobalt oxide and N-doped graphite. Cobalt oxide has multiple redox states for generating redox reactions for charge storage, while N-doped graphite can provide high electrical conductivity for charge transfer. In this study, it is the first time to synthesize binder-free electrodes composed of cobalt oxide and N-doped graphite derived from ZIF67 on carbon cloth (CC) for supercapacitor (SC). Successive oxidation and carbonization along with additional coverage of ZIF67 derivatives are applied to synthesize ZIF67 derivatives composed of cobalt oxide, N-doped graphite and cobalt oxide/N-doped graphite composites with different layer compositions. The highest specific capacitance (C(F)) of 90.0F/g at 20 mV/s is obtained for the oxidized ZIF67/carbonized ZIF67/carbon cloth (O67/C67/CC) electrode, due to the large surface area and high electrical conductivity benefitted from preferable morphology and growing sequence of Co(3)O(4) and N-doped graphite. The symmetric SC composed of O67/C67/CC electrodes shows the maximum energy density of 2.53 Wh/kg at the power density of 50 W/kg. Cycling stability with C(F) retention of 70% and Coulombic efficiency of 65% after 6000 times repeatedly charge/discharge process is also obtained for this symmetric SC.},

keywords = {Binder-free, Carbonization, Cobalt oxide, N-doped carbon, Oxidation, ZIF67},

pubstate = {published},

tppubtype = {article}

}

@article{Huang2022,

title = {Design of LiFePO(4) and porous carbon composites with excellent High-Rate charging performance for Lithium-Ion secondary battery.},

author = {Chen-Yi Huang and Tsung-Rong Kuo and Sibidou Yougbar\'{e} and Lu-Yin Lin},

doi = {10.1016/j.jcis.2021.09.118},

year  = {2022},

date = {2022-02-01},

urldate = {2022-02-01},

journal = {Journal of colloid and interface science},

volume = {607},

issue = {Pt 2},

pages = {1457-1465},

address = {United States},

abstract = {Lithium iron phosphate (LFP) is one of the promising cathode materials of lithium ion battery (LIB), but poor electrical conductivity restricts its electrochemical performance. Carbon coating can improve electrical conductivity of LFP without changing its intrinsic property. Uniform coating of carbon on LFP is significant to avoid charge congregation and unpreferable redox reactions. It is the first time to apply the commercial organic binder, Super P® (SP), as carbon source to achieve uniform coating on LFP as cathode material of LIB. The simple and economical mechanofusion method is firstly applied to coat different amounts of SP on LFP. The LIB with the cathode material of optimized SP-coated LFP shows the highest capacity of 165.6 mAh/g at 0.1C and 59.8 mAh/g at 10C, indicating its high capacity and excellent high-rate charge/discharge capability. SP is applied on other commercial LFP materials, M121 and M23, for carbon coating. Enhanced high-rate charge/discharge capabilities are also achieved for LIB with SP-coated M121 and M23 as cathode materials. This new material and technique for carbon coating is verified to be applicable on different LFP materials. This novel carbon coating method is expected to apply on other cathode materials of LIB with outstanding electrochemical performances.},

keywords = {Carbon coating, High-rate, Lithium ion battery, Lithium iron phosphate, Mechanofusion, Super P®},

pubstate = {published},

tppubtype = {article}

}

@article{Tamburini2022,

title = {Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa.},

author = {Fiona B. Tamburini and Dylan Maghini and Ovokeraye H. Oduaran and Ryan Brewster and Michaella R. Hulley and Venesa Sahibdeen and Shane A. Norris and Stephen Tollman and Kathleen Kahn and Ryan G. Wagner and Alisha N. Wade and Floidy Wafawanaka and F. Xavier G\'{o}mez-Oliv\'{e} and Rhian Twine and Zan\'{e} Lombard and Scott Hazelhurst and Ami S. Bhatt},

doi = {10.1038/s41467-021-27917-x},

year  = {2022},

date = {2022-02-01},

urldate = {2022-02-01},

journal = {Nature communications},

volume = {13},

issue = {1},

pages = {926},

address = {England},

abstract = {Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of research between these extremes limits our understanding of how the gut microbiota relates to health and disease in the majority of the world's population. Here, we evaluate gut microbiome composition in transitioning South African populations using short- and long-read sequencing. We analyze stool from adult females living in rural Bushbuckridge (n = 118) or urban Soweto (n = 51) and find that these microbiomes are taxonomically intermediate between those of individuals living in high-income countries and traditional communities. We demonstrate that reference collections are incomplete for characterizing microbiomes of individuals living outside high-income countries, yielding artificially low beta diversity measurements, and generate complete genomes of undescribed taxa, including Treponema, Lentisphaerae, and Succinatimonas. Our results suggest that the gut microbiome of South Africans does not conform to a simple "western-nonwestern" axis and contains undescribed microbial diversity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tairou2022,

title = {Malaria prevention knowledge, attitudes, and practices (KAP) among adolescents living in an area of persistent transmission in Senegal: Results from a cross-sectional study},

author = {Fassiatou Tairou and Saira Nawaz and Marc Christian Tahita and Samantha Herrera and Babacar Faye and Roger C. K. Tine},

editor = {Sammy O. Sam-Wobo},

url = {https://dx.plos.org/10.1371/journal.pone.0274656},

doi = {10.1371/journal.pone.0274656},

issn = {1932-6203},

year  = {2022},

date = {2022-01-01},

journal = {PLOS ONE},

volume = {17},

issue = {12},

pages = {e0274656},

abstract = {INTRODUCTION While malaria morbidity has sharply declined in several areas in Senegal, it remains an important problem in the southern part of the country, particularly among adolescents. Understanding adolescents' knowledge, attitudes, prevention and care-seeking practices is important to inform more targeted interventions aimed at optimizing adolescents' uptake of malaria prevention and control measures. This study assessed malaria-related knowledge, attitudes, and practices (KAP) among adolescents living in a highly persistent transmission area in Senegal. METHODS A community-based cross-sectional survey was conducted among 391 adolescents living in the Saraya health district. A multistage random sampling technique was used to select households. An electronic questionnaire developed on Open Data Kit (ODK), was used to collect data on socio-demographic characteristics, household assets, adolescents' knowledge of malaria, as well as their attitudes with regards to malaria prevention, and care-seeking behaviors. Bivariate and multivariate analyses were performed to assess factors associated with adolescents' KAP towards malaria. RESULTS Nearly, one-third of the participants had good knowledge of malaria (34.4%) and good practice in regards to malaria preventive measures (32.8%) while 59.0% had a positive attitude and 73.8% had good care-seeking behavior regarding malaria. Multivariate analysis revealed that a primary (aOR = 5.43},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kuo2022-bm,

title = {Unveiling the Antibacterial Mechanism of Gold Nanoclusters via In Situ Transmission Electron Microscopy},

author = {Jui-Chi Kuo and Shih-Hua Tan and Yu-Cheng Hsiao and Chinmaya Mutalik and Hui-Min Chen and Sibidou Yougbar\'{e} and Tsung-Rong Kuo},

doi = {https://doi.org/10.1021/acssuschemeng.1c06714},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {ACS Sustainable Chem Eng},

volume = {10},

number = {1},

pages = {464--471},

publisher = {American Chemical Society},

abstract = {Metal nanoclusters (NCs) with unique chemical and physical properties have been extensively demonstrated to be emerging nanoantibiotics for fighting bacterial infections. Understanding the antibacterial mechanisms of metal nanoclusters is important for evaluating their clinical applications as nanoantibiotics. To understand the antibacterial mechanism, gold nanoclusters (AuNCs) were applied as an antibacterial agent for real-time observations of their interactions with bacteria by in situ transmission electron microscopy (TEM). In this work, a surface ligand of glutathione-conjugated (GSH)-AuNCs was prepared via a simple hydrothermal method. Optical and structural characterizations validated the successful preparation of GSH-AuNCs. Bacterial growth curves of Acetobacter aceti revealed that the antibacterial activity of GSH-AuNCs increased with the weight concentration. The antibacterial activity of GSH-AuNCs was confirmed by the intracellular reactive oxygen species (ROS) generation induced by GSH-AuNCs in A. aceti. Furthermore, real-time observations of interactions between GSH-AuNCs and A. aceti were made using in situ liquid cell TEM. Based on the results of real-time observations, GSH-AuNCs first attached onto the bacterial membranes of A. aceti by physical adsorption and then penetrated into A. aceti by internalization. Eventually, the production of intracellular ROS induced by GSH-AuNCs caused destruction of the bacterial membranes, which led to the death of A. aceti. After the bacterial membranes had been destroyed, A. aceti eventually died.},

keywords = {antibacterial mechanism, in situ TEM, nanocluster, reactive oxygen species, real-time observation},

pubstate = {published},

tppubtype = {article}

}

@article{Somda2022,

title = {Evaluation of antibody responses to tsetse fly saliva in domestic animals in the sleeping sickness endemic foci of Bonon and Sinfra, C\^{o}te d'Ivoire},

author = {Martin Bienvenu Somda and Martial Kassi N'Djetchi and Jacques Kabor\'{e} and Hamidou Ilboudo and Emilie Dama and Soudah Boma and Fabrice Courtin and Anne Poinsignon and Zakaria Bengaly and Franck Remou\'{e} and Adrien Marie Gaston Belem and Bruno Bucheton and Vincent Jamonneau and Mathurin Koffi},

url = {https://linkinghub.elsevier.com/retrieve/pii/S2405939022000892},

doi = {10.1016/j.vprsr.2022.100773},

issn = {24059390},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Veterinary Parasitology: Regional Studies and Reports},

volume = {34},

issue = {2},

pages = {100773},

address = {Switzerland},

abstract = {After intensive control efforts, human African trypanosomiasis (HAT) was declared eliminated in C\^{o}te d'Ivoire as a public health problem in December 2020 and the current objective is to achieve the interruption of the transmission (zero cases). Reaching this objective could be hindered by the existence of an animal reservoir of Trypanosoma (T.) brucei (b.) gambiense. In the framework of a study led in 2013 to assess the role of domestic animals in the epidemiology of HAT in the two last active foci from C\^{o}te d'Ivoire (Bonon and Sinfra), plasmas were sampled from four species of domestic animals for parasitological (microscopic examination by the buffy coat technique (BCT)), serological (immune trypanolysis (TL)) and molecular (specific PCR: TBR for T. brucei s.l., TCF for T. congolense forest type, TVW for T. vivax and PCR for T. b. gambiense) testing. In order to improve the understanding of the involvement/role of these animals in the transmission of T. b. gambiense, we have quantified in this study the IgG response to whole saliva extracts of Glossina palpalis gambiensis in order to perform an association analysis between anti-saliva responses and the positivity of diagnostic tests. Cattle and pigs had significantly higher rates of anti-tsetse saliva responses compared to goats and sheep (p \< 0.01). In addition, the anti-tsetse saliva responses were strongly associated with the parasitology (BCT+), serology (TL+) and PCR (TBR+ and TCF+) results (p \< 0.001). These associations indicate a high level of contacts between the positive/infected animals and tsetse flies. Our findings suggest that protecting cattle and pigs against tsetse bites could have a significant impact in reducing transmission of both animal and human trypanosome species, and advocates for a "One health" approach to better control African trypanosomosis in C\^{o}te d'Ivoire.},

keywords = {Animal reservoirs, Biomarker of exposure, C\^{o}te d'Ivoire, Trypanosoma brucei gambiense, Tsetse fly},

pubstate = {published},

tppubtype = {article}

}

@article{Rouamba2022,

title = {Prospective observational study to evaluate the clinical and biological safety profile of pyronaridine\textendashartesunate in a rural health district in Burkina Faso},

author = {Toussaint Rouamba and Paul Sondo and Isidore W. Yerbanga and Adelaide Compaore and Maminata Traore‐Coulibaly and Franck S. Hien and Nassirou A. Diande and Innocent Valea and Marc Christian Tahita and Rita Baiden and Fred Binka and Halidou Tinto},

url = {https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.987},

doi = {10.1002/prp2.987},

issn = {2052-1707},

year  = {2022},

date = {2022-01-01},

urldate = {2022-02-01},

journal = {Pharmacology Research \& Perspectives},

volume = {10},

issue = {4},

pages = {224-229},

abstract = {\<p\>The assessment in real‐life conditions of the safety and efficacy of new antimalarial drugs is of greatest interest. This study aimed to monitor and evaluate both clinical and biological safety of pyronaridine‐artesunate (PA) in real‐life conditions in Burkina Faso's health system. This was a single‐arm, open‐label study, where patients attending Nanoro health facilities with uncomplicated malaria were consented to be part of a cohort event monitoring (CEM). At inclusion (day‐0), PA was administered orally once a day for 3 days. Patients spontaneous reported any clinical adverse events (AEs) occurring within 28 days following the treatment. Additionally, the study focused on AEs of special interest (AESI), namely clinical signs related to hepatotoxicity and increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST). A nested subset of patients with blood sample collection at day‐0 and day‐7 were monitored to investigate the effect of PA on biochemistry parameters. From September 2017 to October 2018, 2786 patients were treated with PA. About 97.8% (2720/2786) of patients did not report any AE. The most commonly reported events were respiratory, thoracic, and mediastinal disorders (8.3 per 1000), infections and infestations (7.9 per 1000), and gastrointestinal disorders (7.2 per 1000). No clinical or biological hepatotoxicity event related to PA was reported during the follow‐up. Changes in biochemistry parameters remained within laboratory reference ranges. The study showed that PA is a well‐tolerated drug and should be considered as a good option by malaria control programs in countries where existing first‐line antimalarial drugs are continuously threatened by the emergence of drug resistance.\</p\>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Boua2022,

title = {Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans},

author = {Palwende Romuald Boua and Jean-Tristan Brandenburg and Ananyo Choudhury and Hermann Sorgho and Engelbert A. Nonterah and Godfred Agongo and Gershim Asiki and Lisa Micklesfield and Solomon Choma and Francesc Xavier G\'{o}mez-Oliv\'{e} and Scott Hazelhurst and Halidou Tinto and Nigel J. Crowther and Christopher G. Mathew and Mich\`{e}le Ramsay},

url = {https://www.nature.com/articles/s41467-022-28276-x},

doi = {10.1038/s41467-022-28276-x},

issn = {2041-1723},

year  = {2022},

date = {2022-01-01},

urldate = {2022-02-01},

journal = {Nature Communications},

volume = {13},

issue = {1},

pages = {855},

abstract = {\<p\> Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, \<italic\>SIRPA\</italic\> (p = 4.7E-08), and \<italic\>FBXL17\</italic\> (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, \<italic\>SNX29\</italic\> (p = 6.3E-09), and two female-specific loci, \<italic\>LARP6\</italic\> (p = 2.4E-09) and \<italic\>PROK1\</italic\> (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies. \</p\>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sondo2022,

title = {Boosting the impact of seasonal malaria chemoprevention (SMC) through simultaneous screening and treatment of household members of children receiving SMC in Burkina Faso: a protocol for a randomized open label trial},

author = {Paul Sondo and Marc Christian Tahita and Hamidou Ilboudo and Toussaint Rouamba and Karim Derra and Gauthier Tougri and Florence Ou\'{e}draogo and B\'{e}atrice Marie Ad\'{e}la\"{i}de Konseibo and Eli Roamba and Sabina Dahlstr\"{o}m Otienoburu and B\'{e}renger Kabor\'{e} and Kalynn Kennon and Kadija Ou\'{e}draogo and Wend-Timbe-Noma Arlette Ra\"{i}ssa Zongo and Fadima Yaya Bocoum and Kasia Stepniewska and Mehul Dhorda and Philippe J. Gu\'{e}rin and Halidou Tinto},

url = {https://archpublichealth.biomedcentral.com/articles/10.1186/s13690-022-00800-x},

doi = {10.1186/s13690-022-00800-x},

issn = {2049-3258},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Archives of Public Health},

volume = {80},

issue = {1},

pages = {41},

abstract = {BACKGROUND Plasmodium falciparum malaria remains a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) with amodiaquine + sulfadoxine-pyrimethamine is one of the most important preventive interventions. Despite its implementation, the burden of malaria is still very high in children under five years old in Burkina Faso, suggesting that the expected impact of this promising strategy might not be attained. Development of innovative strategies to improve the efficacy of these existing malaria control measures is essential. In such context, we postulate that screening and treatment of malaria in household members of children receiving SMC could greatly improve the impact of SMC intervention and reduce malaria transmission in endemic settings. METHODS This randomized superiority trial will be carried out in the Nanoro health district, Burkina Faso. The unit of randomisation will be the household and all eligible children from a household will be allocated to the same study group. Households with 3-59 months old children will be assigned to either (i) control group (SMC alone) or (ii) intervention (SMC+ screening of household members with standard Histidin Rich Protein Rapid Diagnostic Test (HRP2-RDT) and treatment if positive). The sample size will be 526 isolated households per arm, i.e., around 1052 children under SMC coverage and an expected 1315 household members. Included children will be followed-up for 24 months to fully cover two consecutive malaria transmission seasons and two SMC cycles. Children will be actively followed-up during the malaria transmission seasons while in the dry seasons the follow-up will be passive. CONCLUSION The study will respond to a major public health concern by providing evidence of the efficacy of an innovative strategy to boost the impact of SMC intervention.},

keywords = {Africa, Amodiaquine, Burkina Faso, Chemoprevention, Dihydro artemisinin Piperaquine, Malaria, Plasmodium falciparum, Sulfadoxine-pyrimethamine},

pubstate = {published},

tppubtype = {article}

}

@article{Mduma2022,

title = {Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa},

author = {Estomih Mduma and Tinto Halidou and Berenger Kabor\'{e} and Thomas Walongo and Palpouguini Lompo and Justine Museveni and Joshua Gidabayda and Jean Gratz and Godfrey Guga and Caroline Kimathi and Jie Liu and Paschal Mdoe and Robert Moshiro and Max Petzold and Jan Singlovic and Martine Guillerm and Melba F. Gomes and Eric R. Houpt and Christine M. Halleux},

editor = {Eleni Magira},

url = {https://dx.plos.org/10.1371/journal.pone.0264322},

doi = {10.1371/journal.pone.0264322},

issn = {1932-6203},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {PLOS ONE},

volume = {17},

issue = {2},

pages = {e0264322},

abstract = {BACKGROUND Serious invasive infections in newborns are a major cause of death. Lack of data on etiological causes hampers progress towards reduction of mortality. This study aimed to identify pathogens responsible for such infections in young infants in sub-Saharan Africa and to describe their antibiotics resistance profile. METHODS Between September 2016 and April 2018 we implemented an observational study in two rural sites in Burkina Faso and Tanzania enrolling young infants aged 0-59 days old with serious invasive infection. Blood samples underwent blood culture and molecular biology. RESULTS In total 634 infants with clinical diagnosis of serious invasive infection were enrolled and 4.2% of the infants had a positive blood culture. The most frequent pathogens identified by blood culture were Klebsiella pneumonia and Staphylococcus aureus, followed by Escherichia coli. Gram-negative isolates were only partially susceptible to first line WHO recommended treatment for neonatal sepsis at community level. A total of 18.6% of the infants were PCR positive for at least one pathogen and Escherichia coli and Staphylococcus aureus were the most common bacteria detected. Among infants enrolled, 60/634 (9.5%) died. Positive blood culture but not positive PCR was associated with risk of death. For most deaths, no pathogen was identified either by blood culture or molecular testing, and hence a causal agent remained unclear. Mortality was associated with low body temperature, tachycardia, respiratory symptoms, convulsions, history of difficult feeding, movement only when stimulated or reduced level of consciousness, diarrhea and/or vomiting. CONCLUSION While Klebsiella pneumonia and Staphylococcus aureus, as well as Escherichia coli were pathogens most frequently identified in infants with clinical suspicion of serious invasive infections, most cases remain without definite diagnosis, making more accurate diagnostic tools urgently needed. Antibiotics resistance to first line antibiotics is an increasing challenge even in rural Africa.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}