| Peter J. Neyer, Bérenger Kaboré, Christos T. Nakas, Salou Diallo, Halidou Tinto, Annelies Post, Andre J. Ven, Andreas R. Huber, Carlo R. Largiadèr, Angelika Hammerer-Lercher Increased erythroferrone levels in malarial anaemia Journal Article In: British journal of haematology, vol. 204, iss. 5, pp. 2066-2070, 2024, ISSN: 1365-2141. @article{Neyer2024,
title = {Increased erythroferrone levels in malarial anaemia},
author = {Peter J. Neyer and B\'{e}renger Kabor\'{e} and Christos T. Nakas and Salou Diallo and Halidou Tinto and Annelies Post and Andre J. Ven and Andreas R. Huber and Carlo R. Largiad\`{e}r and Angelika Hammerer-Lercher},
url = {https://pubmed.ncbi.nlm.nih.gov/38279554/},
doi = {10.1111/BJH.19309},
issn = {1365-2141},
year = {2024},
date = {2024-01-01},
journal = {British journal of haematology},
volume = {204},
issue = {5},
pages = {2066-2070},
publisher = {Br J Haematol},
abstract = {We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.},
keywords = {Anemia, Anemia / blood, Anemia / etiology, Angelika Hammerer-Lercher, Animals, B\'{e}renger Kabor\'{e}, Biomarkers* / blood, doi:10.1111/bjh.19309, Female, Hepcidins / blood, Humans, Iron / blood, Iron / metabolism, Iron-Deficiency / blood, Malaria* / blood, Malaria* / complications, Male, MEDLINE, Mice, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peptide Hormones* / blood, Peter J Neyer, pmid:38279554, PubMed Abstract},
pubstate = {published},
tppubtype = {article}
}
We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients. |
