| Junjie Ding, Richard M. Hoglund, Harry Tagbor, Halidou Tinto, Innocent Valéa, Victor Mwapasa, Linda Kalilani-Phiri, Jean Pierre Van Geertruyden, Michael Nambozi, Modest Mulenga, Sebastian Hachizovu, Raffaella Ravinetto, Umberto D'Alessandro, Joel Tarning Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections Journal Article In: CPT: pharmacometrics & systems pharmacology, 2024, ISSN: 2163-8306. @article{Ding2024,
title = {Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections},
author = {Junjie Ding and Richard M. Hoglund and Harry Tagbor and Halidou Tinto and Innocent Val\'{e}a and Victor Mwapasa and Linda Kalilani-Phiri and Jean Pierre Van Geertruyden and Michael Nambozi and Modest Mulenga and Sebastian Hachizovu and Raffaella Ravinetto and Umberto D'Alessandro and Joel Tarning},
url = {https://pubmed.ncbi.nlm.nih.gov/39228131/},
doi = {10.1002/PSP4.13211},
issn = {2163-8306},
year = {2024},
date = {2024-01-01},
journal = {CPT: pharmacometrics \& systems pharmacology},
publisher = {CPT Pharmacometrics Syst Pharmacol},
abstract = {Artemisinin-based combination therapy (ACT) is the first-line recommended treatment for uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often based on small studies and need to be confirmed and validated in larger pregnant patient populations. This study aimed to evaluate the PK properties of amodiaquine and its active metabolite, desethylamodiaquine, and piperaquine in women in their second and third trimester of pregnancy with uncomplicated P. falciparum infections. Eligible pregnant women received either artesunate-amodiaquine (200/540 mg daily},
keywords = {doi:10.1002/psp4.13211, Joel Tarning, Junjie Ding, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, pmid:39228131, PubMed Abstract, Richard M Hoglund},
pubstate = {published},
tppubtype = {article}
}
Artemisinin-based combination therapy (ACT) is the first-line recommended treatment for uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often based on small studies and need to be confirmed and validated in larger pregnant patient populations. This study aimed to evaluate the PK properties of amodiaquine and its active metabolite, desethylamodiaquine, and piperaquine in women in their second and third trimester of pregnancy with uncomplicated P. falciparum infections. Eligible pregnant women received either artesunate-amodiaquine (200/540 mg daily |