Publications

" Our main objective is to develop and maintain over time a good expertise and infrastructure ensuring high quality training and clinical research."
Prof Halidou TINTO, PharmD, Msc, PhD Head of the CRUN

2023
Journal Articles
	Nongodo Firmin Kaboré, Samiratou Ouédraogo, Ariane Kamga Mamguem, Isidore Tiandiogo Traoré, Dramane Kania, Hermann Badolo, Guillaume Sanou, Amariane Koné, Mimbouré Yara, Thérèse Kagoné, Esperance Ouédraogo, Blahima Konaté, Rachel Médah, Nathalie Rekeneire, Armel Poda, Arnaud Eric Diendéré, Boukary Ouédraogo, Oumar Billa, Gilles Paradis, Tienhan Sandrine Dabakuyo-Yonli, Halidou Tinto Incidence rate and predictors of COVID-19 in the two largest cities of Burkina Faso - prospective cohort study in 2021 (ANRS-COV13) Journal Article In: BMC infectious diseases, vol. 23, iss. 1, 2023, ISSN: 1471-2334. Abstract \| BibTeX \| Tags: Adult, Aged, Burkina Faso, Cities, COVID-19, doi:10.1186/s12879-023-08361-2, Female, Halidou Tinto, Humans, Incidence, MEDLINE, Middle Aged, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nongodo Firmin Kaboré, PMC10258776, pmid:37308819, Prospective Studies, PubMed Abstract, Samiratou Ouédraogo, SARS-Cov-2 \| Links: Close Close @article{nokey, title = {Incidence rate and predictors of COVID-19 in the two largest cities of Burkina Faso - prospective cohort study in 2021 (ANRS-COV13)}, author = {Nongodo Firmin Kabor\'{e} and Samiratou Ou\'{e}draogo and Ariane Kamga Mamguem and Isidore Tiandiogo Traor\'{e} and Dramane Kania and Hermann Badolo and Guillaume Sanou and Amariane Kon\'{e} and Mimbour\'{e} Yara and Th\'{e}r\`{e}se Kagon\'{e} and Esperance Ou\'{e}draogo and Blahima Konat\'{e} and Rachel M\'{e}dah and Nathalie Rekeneire and Armel Poda and Arnaud Eric Diend\'{e}r\'{e} and Boukary Ou\'{e}draogo and Oumar Billa and Gilles Paradis and Tienhan Sandrine Dabakuyo-Yonli and Halidou Tinto}, url = {https://pubmed.ncbi.nlm.nih.gov/37308819/}, doi = {10.1186/S12879-023-08361-2}, issn = {1471-2334}, year = {2023}, date = {2023-01-01}, journal = {BMC infectious diseases}, volume = {23}, issue = {1}, publisher = {BMC Infect Dis}, abstract = {Background: Early data on COVID-19 (based primarily on PCR testing) indicated a low burden in Sub-Saharan Africa. To better understand this, this study aimed to estimate the incidence rate and identify predictors of SARS-CoV-2 seroconversion in the two largest cities of Burkina Faso. This study is part of the EmulCOVID-19 project (ANRS-COV13). Methods: Our study utilized the WHO Unity protocol for cohort sero-epidemiological studies of COVID-19 in general population. We conducted random sampling stratified by age group and sex. Individuals aged 10 years and older in the cities of Ouagadougou and Bobo-Dioulasso, Burkina Faso were included and surveyed at 4 time points, each 21 days apart, from March 3 to May 15, 2021. WANTAI SARS-CoV-2 Ab ELISA serological tests were used to detect total antibodies (IgM, IgG) in serum. Predictors were investigated using Cox proportional hazards regression. Results: We analyzed the data from 1399 participants (1051 in Ouagadougou, 348 in Bobo-Dioulasso) who were SARS-CoV-2 seronegative at baseline and had at least one follow-up visit. The incidence rate of SARS-CoV-2 seroconversion was 14.3 cases [95%CI 13.3\textendash15.4] per 100 person-weeks. The incidence rate was almost three times higher in Ouagadougou than in Bobo-Dioulasso (Incidence rate ratio: IRR = 2.7 [2.2\textendash3.2], p \< 0.001). The highest incidence rate was reported among women aged 19\textendash59 years in Ouagadougou (22.8 cases [19.6\textendash26.4] per 100 person-weeks) and the lowest among participants aged 60 years and over in Bobo-Dioulasso, 6.3 cases [4.6\textendash8.6] per 100 person-weeks. Multivariable analysis showed that participants aged 19 years and older were almost twice as likely to seroconvert during the study period compared with those aged 10 to 18 years (Hazard ratio: HR = 1.7 [1.3\textendash2.3], p \< 0.001). Those aged 10\textendash18 years exhibited more asymptomatic forms than those aged 19 years and older, among those who achieved seroconversion (72.9% vs. 40.4%, p \< 0.001). Conclusion: The spread of COVID-19 is more rapid in adults and in large cities. Strategies to control this pandemic in Burkina Faso, must take this into account. Adults living in large cities should be the priority targets for vaccination efforts against COVID-19.}, keywords = {Adult, Aged, Burkina Faso, Cities, COVID-19, doi:10.1186/s12879-023-08361-2, Female, Halidou Tinto, Humans, Incidence, MEDLINE, Middle Aged, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nongodo Firmin Kabor\'{e}, PMC10258776, pmid:37308819, Prospective Studies, PubMed Abstract, Samiratou Ou\'{e}draogo, SARS-Cov-2}, pubstate = {published}, tppubtype = {article} } Close Background: Early data on COVID-19 (based primarily on PCR testing) indicated a low burden in Sub-Saharan Africa. To better understand this, this study aimed to estimate the incidence rate and identify predictors of SARS-CoV-2 seroconversion in the two largest cities of Burkina Faso. This study is part of the EmulCOVID-19 project (ANRS-COV13). Methods: Our study utilized the WHO Unity protocol for cohort sero-epidemiological studies of COVID-19 in general population. We conducted random sampling stratified by age group and sex. Individuals aged 10 years and older in the cities of Ouagadougou and Bobo-Dioulasso, Burkina Faso were included and surveyed at 4 time points, each 21 days apart, from March 3 to May 15, 2021. WANTAI SARS-CoV-2 Ab ELISA serological tests were used to detect total antibodies (IgM, IgG) in serum. Predictors were investigated using Cox proportional hazards regression. Results: We analyzed the data from 1399 participants (1051 in Ouagadougou, 348 in Bobo-Dioulasso) who were SARS-CoV-2 seronegative at baseline and had at least one follow-up visit. The incidence rate of SARS-CoV-2 seroconversion was 14.3 cases [95%CI 13.3–15.4] per 100 person-weeks. The incidence rate was almost three times higher in Ouagadougou than in Bobo-Dioulasso (Incidence rate ratio: IRR = 2.7 [2.2–3.2], p < 0.001). The highest incidence rate was reported among women aged 19–59 years in Ouagadougou (22.8 cases [19.6–26.4] per 100 person-weeks) and the lowest among participants aged 60 years and over in Bobo-Dioulasso, 6.3 cases [4.6–8.6] per 100 person-weeks. Multivariable analysis showed that participants aged 19 years and older were almost twice as likely to seroconvert during the study period compared with those aged 10 to 18 years (Hazard ratio: HR = 1.7 [1.3–2.3], p < 0.001). Those aged 10–18 years exhibited more asymptomatic forms than those aged 19 years and older, among those who achieved seroconversion (72.9% vs. 40.4%, p < 0.001). Conclusion: The spread of COVID-19 is more rapid in adults and in large cities. Strategies to control this pandemic in Burkina Faso, must take this into account. Adults living in large cities should be the priority targets for vaccination efforts against COVID-19. Close
	Blahima Konate, Rachel Medah, Isidore Traore, Samiratou Ouedraogo, Nongodo Firmin Kabore, Ariane Kamga Mamguem, Oumar Billa, Dramane Kania, Hermann Badolo, Esperance Ouedraogo, Nathalie Rekeneire, Armel Poda, Arnaud Eric Diendere, Boukary Ouedraogo, Halidou Tinto, Tienhan Sandrine Dabakuyo-Yonli A Qualitative Study of the Experience of COVID-19 Patients in Burkina Faso Journal Article In: The American journal of tropical medicine and hygiene, vol. 110, iss. 1, pp. 170-178, 2023, ISSN: 1476-1645. Abstract \| BibTeX \| Tags: Blahima Konaté, Burkina Faso / epidemiology, COVID-19, Cross-Sectional Studies, doi:10.4269/ajtmh.22-0351, Humans, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Patients, PMC10793024, pmid:38109766, PubMed Abstract, Qualitative research, Rachel Médah, Tienhan Sandrine Dabakuyo-Yonli \| Links: Close Close @article{Konate2023, title = {A Qualitative Study of the Experience of COVID-19 Patients in Burkina Faso}, author = {Blahima Konate and Rachel Medah and Isidore Traore and Samiratou Ouedraogo and Nongodo Firmin Kabore and Ariane Kamga Mamguem and Oumar Billa and Dramane Kania and Hermann Badolo and Esperance Ouedraogo and Nathalie Rekeneire and Armel Poda and Arnaud Eric Diendere and Boukary Ouedraogo and Halidou Tinto and Tienhan Sandrine Dabakuyo-Yonli}, url = {https://pubmed.ncbi.nlm.nih.gov/38109766/}, doi = {10.4269/AJTMH.22-0351}, issn = {1476-1645}, year = {2023}, date = {2023-01-01}, journal = {The American journal of tropical medicine and hygiene}, volume = {110}, issue = {1}, pages = {170-178}, publisher = {Am J Trop Med Hyg}, abstract = {In Burkina Faso, the health system is characterized by systemic insufficient and antiquated health-care infrastructures. Consequently, few health-care establishments have the required resources to diagnose and manage patients with COVID-19, and fewer still have intensive care facilities for severely ill patients with COVID. Furthermore, there is a widespread scarcity of qualified health-care staff. The aim of this study was to explore the experiences of patients with COVID-19 who recovered after being cared for in Bobo Dioulasso and Ouagadougou. Using individual semistructured interviews, we performed a cross-sectional qualitative, descriptive study from June 12 to 30, 2020 with the aid of 13 well-educated patients who had survived COVID-19. The results reveal that prior to hospital admission, the main reason that prompted patients to seek care was onset of symptoms of COVID-19, regardless of whether they had been in contact with suspected or confirmed cases. Transmission was mainly believed to have occurred in the community, in the hospital, and during travel. Patient management was punctuated by frequent self-medication with medicinal plants or pharmaceutical drugs. The participants reported a negative perception of hospitalization or home-based management, with several forms of stigmatization, but a positive perception influenced by the satisfactory quality of management in health-care centers. This report of patient experiences could be helpful in improving the management of COVID-19 in Burkina Faso, both in the health-care setting and in home-based care.}, keywords = {Blahima Konat\'{e}, Burkina Faso / epidemiology, COVID-19, Cross-Sectional Studies, doi:10.4269/ajtmh.22-0351, Humans, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Patients, PMC10793024, pmid:38109766, PubMed Abstract, Qualitative research, Rachel M\'{e}dah, Tienhan Sandrine Dabakuyo-Yonli}, pubstate = {published}, tppubtype = {article} } Close In Burkina Faso, the health system is characterized by systemic insufficient and antiquated health-care infrastructures. Consequently, few health-care establishments have the required resources to diagnose and manage patients with COVID-19, and fewer still have intensive care facilities for severely ill patients with COVID. Furthermore, there is a widespread scarcity of qualified health-care staff. The aim of this study was to explore the experiences of patients with COVID-19 who recovered after being cared for in Bobo Dioulasso and Ouagadougou. Using individual semistructured interviews, we performed a cross-sectional qualitative, descriptive study from June 12 to 30, 2020 with the aid of 13 well-educated patients who had survived COVID-19. The results reveal that prior to hospital admission, the main reason that prompted patients to seek care was onset of symptoms of COVID-19, regardless of whether they had been in contact with suspected or confirmed cases. Transmission was mainly believed to have occurred in the community, in the hospital, and during travel. Patient management was punctuated by frequent self-medication with medicinal plants or pharmaceutical drugs. The participants reported a negative perception of hospitalization or home-based management, with several forms of stigmatization, but a positive perception influenced by the satisfactory quality of management in health-care centers. This report of patient experiences could be helpful in improving the management of COVID-19 in Burkina Faso, both in the health-care setting and in home-based care. Close