@article{Greenwood2017-is,

title = {Seasonal vaccination against malaria: a potential use for an  imperfect malaria vaccine},

author = {Brian Greenwood and Alassane Dicko and Issaka Sagara and Issaka Zongo and Halidou Tinto and Matthew Cairns and Irene Kuepfer and Paul Milligan and Jean-Bosco Ouedraogo and Ogobara Doumbo and Daniel Chandramohan},

doi = {10.1186/s12936-017-1841-9},

issn = {1475-2875},

year  = {2017},

date = {2017-05-01},

urldate = {2017-05-01},

journal = {Malar. J.},

volume = {16},

number = {1},

pages = {182},

abstract = {In many parts of the African Sahel and sub-Sahel, where malaria 

 remains a major cause of mortality and morbidity, transmission of 

 the infection is highly seasonal. Seasonal malaria 

 chemoprevention (SMC), which involves administration of a full 

 course of malaria treatment to young children at monthly 

 intervals during the high transmission season, is proving to be 

 an effective malaria control measure in these areas. However, SMC 

 does not provide complete protection and it is demanding to 

 deliver for both families and healthcare givers. Furthermore, 

 there is a risk of the emergence in the future of resistance to 

 the drugs, sulfadoxine-pyrimethamine and amodiaquine, that are 

 currently being used for SMC. Substantial progress has been made 

 in the development of malaria vaccines during the past decade and 

 one malaria vaccine, RTS,S/AS01, has received a positive opinion 

 from the European Medicines Authority and will soon be deployed 

 in large-scale, pilot implementation projects in sub-Saharan 

 Africa. A characteristic feature of this vaccine, and potentially 

 of some of the other malaria vaccines under development, is that 

 they provide a high level of efficacy during the period 

 immediately after vaccination, but that this wanes rapidly, 

 perhaps because it is difficult to develop effective 

 immunological memory to malaria antigens in subjects exposed 

 previously to malaria infection. A potentially effective way of 

 using malaria vaccines with high initial efficacy but which 

 provide only a short period of protection could be annual, mass 

 vaccination campaigns shortly before each malaria transmission 

 season in areas where malaria transmission is confined largely to 

 a few months of the year.},

keywords = {Seasonal malaria chemoprevention; Seasonal malaria transmission;   Seasonal malaria vaccination},

pubstate = {published},

tppubtype = {article}

}