CRUN

Publications

" Our main objective is to develop and maintain over time a good expertise and infrastructure ensuring high quality training and clinical research."
Prof Halidou TINTO, PharmD, Msc, PhD Head of the CRUN

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2021

Mphatso Dennis Phiri; Matthew Cairns; Issaka Zongo; Frederic Nikiema; Modibo Diarra; Rakiswendé Serge Yerbanga; Amadou Barry; Amadou Tapily; Samba Coumare; Ismaila Thera; Irene Kuepfer; Paul Milligan; Halidou Tinto; Alassane Dicko; Jean Bosco Ouédraogo; Brian Greenwood; Daniel Chandramohan; Issaka Sagara

The duration of protection from azithromycin against malaria, acute respiratory, gastrointestinal, and skin infections when given alongside seasonal malaria chemoprevention: Secondary analyses of data from a clinical trial in houndé, Burkina Faso, and bougouni, Mali (Journal Article)

In: Clin. Infect. Dis., 73 (7), pp. e2379–e2386, 2021, ISSN: 1537-6591 1058-4838, (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. PMID: 33417683 PMCID: PMC8492219).

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarials/therapeutic use, Azithromycin, Azithromycin/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Child, child mortality, Drug Combinations, duration of protection, Humans, Infant, Malaria/drug therapy/epidemiology/prevention & control, Mali/epidemiology, Preschool, Sahel, seasonal malaria chemoprevention, Seasons)

The duration of protection from azithromycin against malaria,  acute respiratory, gastrointestinal, and skin infections when  given alongside seasonal malaria chemoprevention: Secondary  analyses of data from a clinical trial in houndé, Burkina  Faso, and bougouni, Mali

Stephen A Roberts; Loretta Brabin; Halidou Tinto; Sabine Gies; Salou Diallo; Bernard Brabin

Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data (Journal Article)

In: BMC Public Health, 21 (1), pp. 1764, 2021, ISSN: 1471-2458, (© 2021. The Author(s). PMID: 34579679 PMCID: PMC8477466).

(Abstract | Links | BibTeX | Altmetric | Tags: Abnormal vaginal flora, Adolescents, Bacterial vaginosis, Body Mass Index, Burkina Faso/epidemiology, Child, Female, Humans, Iron, iron biomarkers, Malaria, Malaria/drug therapy/epidemiology, MUAC, Pregnancy, Seasons, Vagina)

Seasonal patterns of malaria, genital infection, nutritional and  iron status in non-pregnant and pregnant adolescents in Burkina  Faso: a secondary analysis of trial data

Adéla"ide Compaoré; Kadija Ouedraogo; Palwende R Boua; Daniella Watson; Sarah H Kehoe; Marie-Louise Newell; Halidou Tinto; Mary Barker; Hermann Sorgho; INPreP group

‘Men are not playing their roles’, maternal and child nutrition in Nanoro, Burkina Faso (Journal Article)

In: Public Health Nutr., 24 (12), pp. 3780–3790, 2021, ISSN: 1475-2727 1368-9800, (Place: England PMID: 33000717).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Child, Child nutrition, Child Nutritional Physiological Phenomena, Community perceptions, Empowerment, Female, Humans, Male, Maternal nutrition, Mothers, Nutritional Status, Pregnancy, Qualitative research)

'Men are not playing their roles', maternal and child nutrition  in Nanoro, Burkina Faso

Koudraogo Bienvenue Yaméogo; Rakiswendé Serge Yerbanga; Seydou Bienvenu Ouattara; Franck A Yao; Thierry Lef`evre; Issaka Zongo; Frederic Niki`ema; Yves Daniel Compaoré; Halidou Tinto; Daniel Chandramohan; Brian Greenwood; Adrien M G Belem; Anna Cohuet; Jean Bosco Ouédraogo

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness (Journal Article)

In: Malar. J., 20 (1), pp. 326, 2021, ISSN: 1475-2875, (© 2021. The Author(s). PMID: 34315475 PMCID: PMC8314489).

(Abstract | Links | BibTeX | Altmetric | Tags: Amodiaquine/administration & dosage, Animals, Antimalarials/administration & dosage, Chemoprevention, Child, Culicidae/physiology, Drug Combinations, Falciparum/prevention & control/transmission, Gametocytes, Genetic Fitness, Humans, Malaria, Plasmodium falciparum/physiology, Preschool, Pyrimethamine/administration & dosage, seasonal malaria chemoprevention, Seasons, Sulfadoxine/administration & dosage, Transmission)

Effect of seasonal malaria chemoprevention plus azithromycin on  Plasmodium falciparum transmission: gametocyte infectivity and  mosquito fitness

Mariken Wit; Matthew Cairns; Yves Daniel Compaoré; Issaka Sagara; Irene Kuepfer; Issaka Zongo; Amadou Barry; Modibo Diarra; Amadou Tapily; Samba Coumare; Ismaila Thera; Frederic Nikiema; R Serge Yerbanga; Rosemonde M Guissou; Halidou Tinto; Alassane Dicko; Daniel Chandramohan; Brian Greenwood; Jean Bosco Ouedraogo

Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria (Journal Article)

In: Malar. J., 20 (1), pp. 274, 2021, ISSN: 1475-2875, (PMID: 34158054 PMCID: PMC8220741).

(Abstract | Links | BibTeX | Altmetric | Tags: Acute malnutrition, Antimalarials/administration & dosage, Azithromycin/administration & dosage, Burkina Faso, Burkina Faso/epidemiology, Child, Chronic malnutrition, Female, Humans, Incidence, Infant, Malaria, Malaria/epidemiology/transmission, Male, Nutritional Status, Preschool, seasonal malaria chemoprevention, Seasons)

Nutritional status in young children prior to the malaria  transmission season in Burkina Faso and Mali, and its impact on  the incidence of clinical malaria

Annelies Post; Berenger Kaboré; Mike Berendsen; Salou Diallo; Ousmane Traore; Rob J W Arts; Mihai G Netea; Leo A B Joosten; Halidou Tinto; Jan Jacobs; Quirijn Mast; André Ven

Altered ex-vivo cytokine responses in children with asymptomatic Plasmodium falciparum infection in Burkina Faso: An additional argument to treat asymptomatic malaria? (Journal Article)

In: Front. Immunol., 12 , pp. 614817, 2021, ISSN: 1664-3224, (Copyright © 2021 Post, Kaboré, Berendsen, Diallo, Traore, Arts, Netea, Joosten, Tinto, Jacobs, de Mast and van der Ven. PMID: 34177883 PMCID: PMC8220162).

(Abstract | Links | BibTeX | Altmetric | Tags: Asymptomatic Diseases, asymptomatic malaria, bacteraemia, Bacteremia, bloodstream infection, Burkina Faso/epidemiology, Cells, Child, Cultured, Cytokines/metabolism, Endemic Diseases, Female, Humans, Infant, iNTS, Lipopolysaccharides/immunology, Malaria/epidemiology/immunology, Male, Parasite Load, Plasmodium falciparum/physiology, Preschool, Salmonella)

Altered ex-vivo cytokine responses in children with asymptomatic  Plasmodium falciparum infection in Burkina Faso: An additional  argument to treat asymptomatic malaria?

Paul Sondo; Marc Christian Tahita; Toussaint Rouamba; Karim Derra; Bérenger Kaboré; Cheick Sa"id Compaoré; Florence Ouédraogo; Eli Rouamba; Hamidou Ilboudo; Estelle A"issa Bambara; Macaire Nana; Edmond Yabré Sawadogo; Hermann Sorgho; Athanase Mwinessobaonfou Somé; Innocent Valéa; Prabin Dahal; Maminata Traoré/Coulibaly; Halidou Tinto

Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy’Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT) (Journal Article)

In: Trials, 22 (1), pp. 360, 2021, ISSN: 1745-6215, (PMID: 34030705 PMCID: PMC8142067).

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarials/adverse effects, Burkina Faso/epidemiology, Chemoprevention, Child, Child Nutrition Disorders, Dietary Supplements, Humans, Infant, Malaria, Malaria/diagnosis/epidemiology/prevention & control, Malnutrition, Malnutrition/diagnosis/drug therapy/prevention & control, Pharmaceutical Preparations, Plumpy’Doz™, Preschool, Randomized controlled trial, Seasonal chemoprevention, Seasons, Vitamin A, Vitamin A/adverse effects, Zinc)

Assessment of a combined strategy of seasonal malaria  chemoprevention and supplementation with vitamin A, zinc and  Plumpy'Doz™ to prevent malaria and malnutrition in children  under 5 years old in Burkina Faso: a randomized open-label trial  (SMC-NUT)

Joel D Bognini; Sekou Samadoulougou; Mady Ouedraogo; Tiga David Kangoye; Carine Van Malderen; Halidou Tinto; Fati Kirakoya-Samadoulougou

Socioeconomic inequalities in curative healthcare-seeking for children under five before and after the free healthcare initiative in Sierra Leone: analysis of population-based survey data (Journal Article)

In: Int. J. Equity Health, 20 (1), pp. 124, 2021, ISSN: 1475-9276, (PMID: 34020665 PMCID: PMC8140517).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Adult, Child, Children under five, Delivery of Health Care/economics, Female, Health Care Surveys, Healthcare Disparities/economics/statistics & numerical data, Healthcare utilization, Humans, Infant, Male, Parents/psychology, Patient Acceptance of Health Care/statistics & numerical data, Preschool, Sierra Leone, Socioeconomic Factors, Young Adult)

Socioeconomic inequalities in curative healthcare-seeking for  children under five before and after the free healthcare  initiative in Sierra Leone: analysis of population-based survey  data

Yeka Adoke; Rella Zoleko-Manego; Serge Ouoba; Alfred B Tiono; Grace Kaguthi; Juv^encio Eduardo Bonzela; Tran Thanh Duong; Alain Nahum; Marielle Bouyou-Akotet; Bernhards Ogutu; Alphonse Ouedraogo; Fiona Macintyre; Andreas Jessel; Bart Laurijssens; Mohammed H Cherkaoui-Rbati; Cathy Cantalloube; Anne Claire Marrast; Rapha"el Bejuit; David White; Timothy N C Wells; Florian Wartha; Didier Leroy; Afizi Kibuuka; Ghyslain Mombo-Ngoma; Daouda Ouattara; Ir`ene Mugenya; Bui Quang Phuc; Francis Bohissou; Denise P Mawili-Mboumba; Fredrick Olewe; Issiaka Soulama; Halidou Tinto; FALCI Study Group

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria (Journal Article)

In: Malar. J., 20 (1), pp. 222, 2021, ISSN: 1475-2875, (PMID: 34011358 PMCID: PMC8135182).

(Abstract | Links | BibTeX | Altmetric | Tags: Adamantane/administration & dosage/analogs & derivatives, Adolescent, Adult, Aged, Aminoquinolines/administration & dosage, Benin, Burkina Faso, C580Y, Child, Combination treatment, Double-Blind Method, Drug Combinations, Exposure–response, Falciparum/prevention & control, Female, Ferroquine, Ferrous Compounds/administration & dosage, Gabon, Humans, Infant, Kelch-13 mutation, Kenya, Malaria, Male, Metallocenes/administration & dosage, Middle Aged, Mozambique, Parasite clearance, Peroxides/administration & dosage, Pharmacokinetics/pharmacodynamics, Plasmodium falciparum/drug effects, Preschool, resistance, Uganda, Vietnam, Vomiting, Young Adult)

A randomized, double-blind, phase 2b study to investigate the  efficacy, safety, tolerability and pharmacokinetics of a  single-dose regimen of ferroquine with artefenomel in adults and  children with uncomplicated Plasmodium falciparum malaria

Annelies Post; Berenger Kaboré; Joel Bognini; Salou Diallo; Palpouguini Lompo; Basile Kam; Natacha Herssens; Fred Opzeeland; Christa E Gaast-de Jongh; Jeroen D Langereis; Marien I Jonge; Janette Rahamat-Langendoen; Teun Bousema; Heiman Wertheim; Robert W Sauerwein; Halidou Tinto; Jan Jacobs; Quirijn Mast; Andre J Ven

Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso (Journal Article)

In: PLoS Negl. Trop. Dis., 15 (3), pp. e0009187, 2021, ISSN: 1935-2735 1935-2727, (PMID: 33647009 PMCID: PMC7951874).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Automation, Bacteremia/diagnosis, Burkina Faso, C-Reactive Protein/analysis, Child, Coinfection/diagnosis/microbiology/parasitology, Female, Fever of Unknown Origin/diagnosis, Humans, Infant, Laboratory/methods, Malaria/diagnosis, Male, Preschool, Procalcitonin/analysis, Prospective Studies, Sensitivity and Specificity, Software, Virus Diseases/diagnosis)

Infection Manager System (IMS) as a new hemocytometry-based  bacteremia detection tool: A diagnostic accuracy study in a  malaria-endemic area of Burkina Faso

Palpouguini Lompo; Marc Christian Tahita; Hermann Sorgho; William Kaboré; Adama Kazienga; Ashmed Cheick Bachirou Nana; Hamtandi Magloire Natama; Isidore Juste Ouindgueta Bonkoungou; Nicolas Barro; Halidou Tinto

Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso (Journal Article)

In: Pan Afr. Med. J., 38 , pp. 259, 2021, ISSN: 1937-8688, (Copyright: Palpouguini Lompo et al. PMID: 34104307 PMCID: PMC8164431).

(Abstract | Links | BibTeX | Altmetric | Tags: Abdominal Pain/epidemiology, Acute Disease, bacteria, Burkina Faso, Burkina Faso/epidemiology, Child, Comorbidity, Diarrhea, Diarrhea/epidemiology/microbiology, Female, Fever/epidemiology, Giardiasis/epidemiology, Humans, Infant, infectious, Malaria, Malaria/epidemiology, Male, parasite, pathogens, Preschool, Prevalence, Risk Factors, rotavirus, Rotavirus Infections/epidemiology, Rural Population, Seasons, Vomiting/epidemiology)

Pathogens associated with acute diarrhea, and comorbidity with  malaria among children under five years old in rural Burkina  Faso

Adama Gansané; Leah F Moriarty; Didier Ménard; Isidore Yerbanga; Esperance Ouedraogo; Paul Sondo; Rene Kinda; Casimir Tarama; Edwige Soulama; Madou Tapsoba; David Kangoye; Cheick Said Compaore; Ousmane Badolo; Blami Dao; Samuel Tchwenko; Halidou Tinto; Innocent Valea

Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017-2018 (Journal Article)

In: Malar. J., 20 (1), pp. 48, 2021, ISSN: 1475-2875.

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarial, Antimalarials/pharmacology, Artemether, Artemether-lumefantrine, Artemisinins/pharmacology, Burkina Faso, Child, Dihydroartemisinin-piperaquine, Drug Resistance, Efficacy, Falciparum/drug therapy, Female, Lumefantrine Drug Combination/pharmacology, Malaria, Male, Plasmodium falciparum, Preschool, Quinolines/pharmacology)

Anti-malarial efficacy and resistance monitoring of  artemether-lumefantrine and dihydroartemisinin-piperaquine shows  inadequate efficacy in children in Burkina Faso, 2017-2018

2020

André Lin Ouédraogo; Julie Zhang; Halidou Tinto; Innocent Valéa; Edward A Wenger

A microplanning model to improve door-to-door health service delivery: the case of Seasonal Malaria Chemoprevention in Sub-Saharan African villages (Journal Article)

In: BMC Health Serv. Res., 20 (1), pp. 1128, 2020, ISSN: 1472-6963, (PMID: 33287825 PMCID: PMC7720067).

(Abstract | Links | BibTeX | Altmetric | Tags: Africa South of the Sahara/epidemiology, Antimalarials/therapeutic use, Burkina Faso, Chemoprevention, Child, CHW, Community health worker, Door-to-door, Health Services, Humans, Malaria, Malaria/drug therapy/epidemiology/prevention & control, Microplanning, Model, Satellite imagerySeasonal malaria chemoprevention, Seasons, SMC)

A microplanning model to improve door-to-door health service  delivery: the case of Seasonal Malaria Chemoprevention in  Sub-Saharan African villages

Laura Skrip; Karim Derra; Mikaila Kaboré; Navideh Noori; Adama Gansané; Innocent Valéa; Halidou Tinto; Bicaba W Brice; Mollie Van Gordon; Brittany Hagedorn; Hervé Hien; Benjamin M Althouse; Edward A Wenger; André Lin Ouédraogo

Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis (Journal Article)

In: Int. J. Infect. Dis., 101 , pp. 194–200, 2020, ISSN: 1878-3511 1201-9712, (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. PMID: 32987177 PMCID: PMC7518969).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Adult, Africa South of the Sahara, Aged, Antiviral Agents/administration & dosage, Asia/epidemiology, Burkina Faso, Burkina Faso/epidemiology, Child, Clinical management of SARS-CoV-2 infection: convalescent plasma, COVID-19/drug therapy/epidemiology/mortality/therapy, Europe/epidemiology, Female, Health systems strengthening, Humans, Immunization, Infant, Male, Mortality, Oxygen therapy, Pandemics, Passive, Preschool, Retrospective Studies, SARS-CoV-2 infection, SARS-CoV-2/drug effects/physiology, sub-Saharan Africa, Young Adult)

Clinical management and mortality among COVID-19 cases in  sub-Saharan Africa: A retrospective study from Burkina Faso and  simulated case analysis