 | Engelbert A Nonterah, Palwende R Boua, Kerstin Klipstein-Grobusch, Gershim Asiki, Lisa K Micklesfield, Godfred Agongo, Stuart A Ali, Felistas Mashinya, Herman Sorgho, Seydou Nakanabo-Diallo, Cornelius Debpuur, Catherine Kyobutungi, Marianne Alberts, Shane Norris, Stephen Tollman, Halidou Tinto, Cassandra C Soo, Freedom Mukomana, Scott Hazelhurst, Alisha N Wade, Kathleen Kahn, Abraham R Oduro, Diederick E Grobbee, Osman Sankoh, Mich`ele Ramsay, Michiel L Bots, Nigel J Crowther, members, AWI-Gen, H3Africa Consortium Classical cardiovascular risk factors and HIV are associated with carotid intima-media thickness in adults from sub-Saharan Africa: Findings from H3Africa AWI-Gen study (Journal Article) In: J. Am. Heart Assoc., vol. 8, no. 14, pp. e011506, 2019, ISSN: 2047-9980. @article{Nonterah2019-zz,
title = {Classical cardiovascular risk factors and HIV are associated with carotid intima-media thickness in adults from sub-Saharan Africa: Findings from H3Africa AWI-Gen study},
author = {Engelbert A Nonterah and Palwende R Boua and Kerstin Klipstein-Grobusch and Gershim Asiki and Lisa K Micklesfield and Godfred Agongo and Stuart A Ali and Felistas Mashinya and Herman Sorgho and Seydou Nakanabo-Diallo and Cornelius Debpuur and Catherine Kyobutungi and Marianne Alberts and Shane Norris and Stephen Tollman and Halidou Tinto and Cassandra C Soo and Freedom Mukomana and Scott Hazelhurst and Alisha N Wade and Kathleen Kahn and Abraham R Oduro and Diederick E Grobbee and Osman Sankoh and Mich`ele Ramsay and Michiel L Bots and Nigel J Crowther and members and AWI-Gen and H3Africa Consortium},
doi = {10.1161/JAHA.118.011506},
issn = {2047-9980},
year = {2019},
date = {2019-07-01},
urldate = {2019-07-01},
journal = {J. Am. Heart Assoc.},
volume = {8},
number = {14},
pages = {e011506},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
abstract = {Background Studies on the determinants of carotid intima-media
thickness ( CIMT ), a marker of sub-clinical atherosclerosis,
mostly come from white, Asian, and diasporan black populations.
We present CIMT data from sub-Saharan Africa, which is
experiencing a rising burden of cardiovascular diseases and
infectious diseases. Methods and Results The H3 (Human
Hereditary and Health) in Africa's AWI-Gen (African-Wits-INDEPTH
partnership for Genomic) study is a cross-sectional study
conducted in adults aged 40 to 60 years from Burkina Faso,
Kenya, Ghana, and South Africa. Cardiovascular disease risk and
ultrasonography of the CIMT of right and left common carotids
were measured. Multivariable linear and mixed-effect multilevel
regression modeling was applied to determine factors related to
CIMT. Data included 8872 adults (50.8% men), mean age of
50$pm$6 years with age- and sex-adjusted mean ($pm$SE) CIMT of
640$pm$123$mu$m. Participants from Ghana and Burkina Faso had higher CIMT compared with other sites. Age ($beta$ = 6.77,
95%CI [6.34-7.19]), body mass index (17.6[12.5-22.8]), systolic
blood pressure (7.52[6.21-8.83]), low-density lipoprotein
cholesterol (5.08[2.10-8.06]) and men (10.3[4.75- 15.9]) were
associated with higher CIMT. Smoking was associated with higher
CIMT in men. High-density lipoprotein cholesterol (-12.2 [-17.9-
-6.41]), alcohol consumption (-13.5 [-19.1--7.91]) and HIV
(-8.86 [-15.7--2.03]) were inversely associated with CIMT.
Conclusions Given the rising prevalence of cardiovascular
diseases risk factors in sub-Saharan Africa, atherosclerotic
diseases may become a major pan-African epidemic unless
preventive measures are taken particularly for prevention of
hypertension, obesity, and smoking. HIV -specific studies are
needed to fully understand the association between HIV and CIMT
in sub-Saharan Africa.},
keywords = {cardiovascular disease; carotid intima-media thickness; epidemiological transition; prevention; sub-Saharan Africa},
pubstate = {published},
tppubtype = {article}
}
Background Studies on the determinants of carotid intima-media
thickness ( CIMT ), a marker of sub-clinical atherosclerosis,
mostly come from white, Asian, and diasporan black populations.
We present CIMT data from sub-Saharan Africa, which is
experiencing a rising burden of cardiovascular diseases and
infectious diseases. Methods and Results The H3 (Human
Hereditary and Health) in Africa’s AWI-Gen (African-Wits-INDEPTH
partnership for Genomic) study is a cross-sectional study
conducted in adults aged 40 to 60 years from Burkina Faso,
Kenya, Ghana, and South Africa. Cardiovascular disease risk and
ultrasonography of the CIMT of right and left common carotids
were measured. Multivariable linear and mixed-effect multilevel
regression modeling was applied to determine factors related to
CIMT. Data included 8872 adults (50.8% men), mean age of
50$pm$6 years with age- and sex-adjusted mean ($pm$SE) CIMT of
640$pm$123$mu$m. Participants from Ghana and Burkina Faso had higher CIMT compared with other sites. Age ($beta$ = 6.77,
95%CI [6.34-7.19]), body mass index (17.6[12.5-22.8]), systolic
blood pressure (7.52[6.21-8.83]), low-density lipoprotein
cholesterol (5.08[2.10-8.06]) and men (10.3[4.75- 15.9]) were
associated with higher CIMT. Smoking was associated with higher
CIMT in men. High-density lipoprotein cholesterol (-12.2 [-17.9-
-6.41]), alcohol consumption (-13.5 [-19.1–7.91]) and HIV
(-8.86 [-15.7–2.03]) were inversely associated with CIMT.
Conclusions Given the rising prevalence of cardiovascular
diseases risk factors in sub-Saharan Africa, atherosclerotic
diseases may become a major pan-African epidemic unless
preventive measures are taken particularly for prevention of
hypertension, obesity, and smoking. HIV -specific studies are
needed to fully understand the association between HIV and CIMT
in sub-Saharan Africa. |
