@article{Sondo2015-fh,

title = {Dynamic of plasmodium falciparum chloroquine resistance 

 transporter gene Pfcrt K76T mutation five years after 

 withdrawal of chloroquine in Burkina Faso},

author = {Paul Sondo and Karim Derra and Zekiba Tarnagda and Seydou Diallo Nakanabo and Odile Zampa and Adama Kazienga and Innocent Valea and Hermann Sorgho and Jean-Bosco Ouedraogo and Tinga Robert Guiguemde and Halidou Tinto},

year  = {2015},

date = {2015-06-01},

journal = {Pan Afr. Med. J.},

volume = {21},

pages = {101},

publisher = {Pan African Medical Journal},

abstract = {We investigated the evolution of Pfcrt K76T mutation five years 

 after the withdrawal of chloroquine in Burkina Faso. A total of 

 675 clinical isolates collected from October 2010 to September 

 2012 were successfully genotyped. Single nucleotide polymorphism 

 in Pfcrt (codon 76) gene was analyzed. The prevalence of 

 resistant Pfcrt 76T allele was 20.55%. There was a progressive 

 decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive 

 return of the wild type Pfcrt K76 in Burkina Faso but the 

 prevalence of the mutants Pfcrt T76 still remains high.},

keywords = {Malaria; chloroquine resistance; pfcrt; plasmodium falciparum},

pubstate = {published},

tppubtype = {article}

}