| Paul Sondo, Bérenger Kaboré, Toussaint Rouamba, Eulalie Compaoré, Yssimini Nadège Guillène Tibiri, Hyacinthe Abd El Latif Faïçal Kaboré, Karim Derra, Marc Christian Tahita, Hamidou Ilboudo, Gauthier Tougri, Ismaïla Bouda, Tikanou Dakyo, Hyacinthe Kafando, Florence Ouédraogo, Eli Rouamba, So Franck Hien, Adama Kazienga, Cheick Saïd Compaoré, Estelle Bambara, Macaire Nana, Prabin Dahal, Franck Garanet, William Kaboré, Thierry Léfèvre, Philippe Guerin, Halidou Tinto Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial Journal Article In: Malaria journal, vol. 22, iss. 1, 2023, ISSN: 1475-2875. @article{Sondo2023,
title = {Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial},
author = {Paul Sondo and B\'{e}renger Kabor\'{e} and Toussaint Rouamba and Eulalie Compaor\'{e} and Yssimini Nad\`{e}ge Guill\`{e}ne Tibiri and Hyacinthe Abd El Latif Fa\"{i}\c{c}al Kabor\'{e} and Karim Derra and Marc Christian Tahita and Hamidou Ilboudo and Gauthier Tougri and Isma\"{i}la Bouda and Tikanou Dakyo and Hyacinthe Kafando and Florence Ou\'{e}draogo and Eli Rouamba and So Franck Hien and Adama Kazienga and Cheick Sa\"{i}d Compaor\'{e} and Estelle Bambara and Macaire Nana and Prabin Dahal and Franck Garanet and William Kabor\'{e} and Thierry L\'{e}f\`{e}vre and Philippe Guerin and Halidou Tinto},
url = {https://pubmed.ncbi.nlm.nih.gov/37853408/},
doi = {10.1186/S12936-023-04745-6},
issn = {1475-2875},
year = {2023},
date = {2023-01-01},
journal = {Malaria journal},
volume = {22},
issue = {1},
publisher = {Malar J},
abstract = {Background: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. Methods: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A},
keywords = {Antimalarials* / therapeutic use, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Chemoprevention, Child, Cross-Sectional Studies, Dietary Supplements, doi:10.1186/s12936-023-04745-6, Halidou Tinto, Humans, Infant, Malaria* / epidemiology, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nutrients, Paul Sondo, PMC10585892, pmid:37853408, Preschool, PubMed Abstract, Randomized controlled trial, Seasons, Vitamin A / therapeutic use},
pubstate = {published},
tppubtype = {article}
}
Background: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. Methods: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A |
 | Paul Sondo, Marc Christian Tahita, Toussaint Rouamba, Karim Derra, Bérenger Kaboré, Cheick Sa"id Compaoré, Florence Ouédraogo, Eli Rouamba, Hamidou Ilboudo, Estelle A"issa Bambara, Macaire Nana, Edmond Yabré Sawadogo, Hermann Sorgho, Athanase Mwinessobaonfou Somé, Innocent Valéa, Prabin Dahal, Maminata Traoré/Coulibaly, Halidou Tinto Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy'Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT) Journal Article In: Trials, vol. 22, no. 1, pp. 360, 2021, ISSN: 1745-6215, (PMID: 34030705
PMCID: PMC8142067). @article{Sondo2021-kc,
title = {Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy'Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT)},
author = {Paul Sondo and Marc Christian Tahita and Toussaint Rouamba and Karim Derra and B\'{e}renger Kabor\'{e} and Cheick Sa"id Compaor\'{e} and Florence Ou\'{e}draogo and Eli Rouamba and Hamidou Ilboudo and Estelle A"issa Bambara and Macaire Nana and Edmond Yabr\'{e} Sawadogo and Hermann Sorgho and Athanase Mwinessobaonfou Som\'{e} and Innocent Val\'{e}a and Prabin Dahal and Maminata Traor\'{e}/Coulibaly and Halidou Tinto},
doi = {10.1186/s13063-021-05320-7},
issn = {1745-6215},
year = {2021},
date = {2021-05-24},
urldate = {2021-05-24},
journal = {Trials},
volume = {22},
number = {1},
pages = {360},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Malaria and malnutrition represent major public
health concerns worldwide especially in Sub-Sahara Africa.
Despite implementation of seasonal malaria chemoprophylaxis
(SMC), an intervention aimed at reducing malaria incidence among
children aged 3-59 months, the burden of malaria and associated
mortality among children below age 5 years remains high in
Burkina Faso. Malnutrition, in particular micronutrient
deficiency, appears to be one of the potential factors that can
negatively affect the effectiveness of SMC. Treating
micronutrient deficiencies is known to reduce the incidence of
malaria in highly prevalent malaria zone such as rural settings.
Therefore, we hypothesized that a combined strategy of SMC
together with a daily oral nutrients supplement will enhance the
immune response and decrease the incidence of malaria and
malnutrition among children under SMC coverage. METHODS:
Children (6-59 months) under SMC coverage receiving vitamin A
supplementation will be randomly assigned to one of the three
study arms (a) SMC + vitamin A alone, (b) SMC + vitamin A +
zinc, or (c) SMC + vitamin A + Plumpy'Doz™ using 1:1:1
allocation ratio. After each SMC monthly distribution, children
will be visited at home to confirm drug administration and
followed-up for 1 year. Anthropometric indicators will be
recorded at each visit and blood samples will be collected for
microscopy slides, haemoglobin measurement, and spotted onto
filter paper for further PCR analyses. The primary outcome
measure is the incidence of malaria in each arm. Secondary
outcome measures will include mid-upper arm circumference and
weight gain from baseline measurements, coverage and compliance
to SMC, occurrence of adverse events (AEs), and prevalence of
molecular markers of antimalarial resistance comprising Pfcrt,
Pfmdr1, Pfdhfr, and Pfdhps. DISCUSSION: This study will
demonstrate an integrated strategy of malaria and malnutrition
programmes in order to mutualize resources for best impact. By
relying on existing strategies, the policy implementation of
this joint intervention will be scalable at country and regional
levels. TRIAL REGISTRATION: ClinicalTrials.gov NCT04238845 .
Registered on 23 January 2020
https://clinicaltrials.gov/ct2/show/NCT04238845.},
note = {PMID: 34030705
PMCID: PMC8142067},
keywords = {Antimalarials/adverse effects, Burkina Faso/epidemiology, Chemoprevention, Child, Child Nutrition Disorders, Dietary Supplements, Humans, Infant, Malaria, Malaria/diagnosis/epidemiology/prevention \& control, Malnutrition, Malnutrition/diagnosis/drug therapy/prevention \& control, Pharmaceutical Preparations, Plumpy’Doz™, Preschool, Randomized controlled trial, Seasonal chemoprevention, Seasons, Vitamin A, Vitamin A/adverse effects, Zinc},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria and malnutrition represent major public
health concerns worldwide especially in Sub-Sahara Africa.
Despite implementation of seasonal malaria chemoprophylaxis
(SMC), an intervention aimed at reducing malaria incidence among
children aged 3-59 months, the burden of malaria and associated
mortality among children below age 5 years remains high in
Burkina Faso. Malnutrition, in particular micronutrient
deficiency, appears to be one of the potential factors that can
negatively affect the effectiveness of SMC. Treating
micronutrient deficiencies is known to reduce the incidence of
malaria in highly prevalent malaria zone such as rural settings.
Therefore, we hypothesized that a combined strategy of SMC
together with a daily oral nutrients supplement will enhance the
immune response and decrease the incidence of malaria and
malnutrition among children under SMC coverage. METHODS:
Children (6-59 months) under SMC coverage receiving vitamin A
supplementation will be randomly assigned to one of the three
study arms (a) SMC + vitamin A alone, (b) SMC + vitamin A +
zinc, or (c) SMC + vitamin A + Plumpy'Doz™ using 1:1:1
allocation ratio. After each SMC monthly distribution, children
will be visited at home to confirm drug administration and
followed-up for 1 year. Anthropometric indicators will be
recorded at each visit and blood samples will be collected for
microscopy slides, haemoglobin measurement, and spotted onto
filter paper for further PCR analyses. The primary outcome
measure is the incidence of malaria in each arm. Secondary
outcome measures will include mid-upper arm circumference and
weight gain from baseline measurements, coverage and compliance
to SMC, occurrence of adverse events (AEs), and prevalence of
molecular markers of antimalarial resistance comprising Pfcrt,
Pfmdr1, Pfdhfr, and Pfdhps. DISCUSSION: This study will
demonstrate an integrated strategy of malaria and malnutrition
programmes in order to mutualize resources for best impact. By
relying on existing strategies, the policy implementation of
this joint intervention will be scalable at country and regional
levels. TRIAL REGISTRATION: ClinicalTrials.gov NCT04238845 .
Registered on 23 January 2020
https://clinicaltrials.gov/ct2/show/NCT04238845. |
