 | Massa Dit Achille Bonko, Marc Christian Tahita, Francois Kiemde, Palpouguini Lompo, Sibidou Yougbaré, Athanase M Some, Halidou Tinto, Petra F Mens, Sandra Menting, Henk D F H Schallig Antibiotic susceptibility profile of bacterial isolates from febrile children under 5 years of age in Nanoro, Burkina Faso (Journal Article) In: Trop. Med. Int. Health, vol. 26, no. 10, pp. 1220–1230, 2021, ISSN: 1365-3156 1360-2276, (© 2021 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd.
Place: England
PMID: 34185935). @article{Bonko2021-en,
title = {Antibiotic susceptibility profile of bacterial isolates from febrile children under 5 years of age in Nanoro, Burkina Faso},
author = {Massa Dit Achille Bonko and Marc Christian Tahita and Francois Kiemde and Palpouguini Lompo and Sibidou Yougbar\'{e} and Athanase M Some and Halidou Tinto and Petra F Mens and Sandra Menting and Henk D F H Schallig},
doi = {10.1111/tmi.13644},
issn = {1365-3156 1360-2276},
year = {2021},
date = {2021-10-01},
urldate = {2021-10-01},
journal = {Trop. Med. Int. Health},
volume = {26},
number = {10},
pages = {1220--1230},
publisher = {Wiley},
abstract = {OBJECTIVES: Antibiotics efficacy is severely threatened due to
emerging resistance worldwide, but there is a paucity of
antibiotics efficacy data for the West African region in
general. Therefore, this study aimed to determine the antibiotic
susceptibility profile of bacterial isolated from febrile
children under 5 years of age in Nanoro (Burkina Faso). METHODS:
Blood, stool and urine samples were collected from 1099 febrile
children attending peripheral health facilities and the referral
hospital in Nanoro Health district. Bacterial isolates from
these samples were assessed for their susceptibility against
commonly used antibiotics by Kirby-Bauer method. RESULTS: In
total, 141 bacterial isolates were recovered from 127 febrile
children of which 65 from blood, 65 from stool and 11 from
urine. Salmonella isolates were most frequently isolated and
found to be highly resistant to ampicillin (70%; 56/80) and
trimethoprim-sulphamethoxazole (65%; 52/80). Escherichia coli
isolates showed a high resistance rate to
trimethoprim-sulphamethoxazole (100%), ampicillin (100%),
ciprofloxacin (71.4%; 10/14), amoxicillin-clavulanate (64.3%;
9/14), ceftriaxone (64.3%; 9/14) and gentamycin (50%; 7/14).
Moreover, half of the E. coli isolates produced \ss-lactamase
suggesting multi-drug resistance against $beta$-lactam as well
as non-$beta$-lactam antibiotics. Multi-drug resistance was
observed in 54.6% (59/108) of the isolates, mainly
Gram-negative bacteria. CONCLUSIONS: This study showed high
resistance rates to common antibiotics used to treat bacterial
infections in Nanoro. The work prompts the need to expand
antibiotic resistance surveillance studies in Burkina Faso.},
note = {© 2021 The Authors Tropical Medicine \& International Health Published by John Wiley \& Sons Ltd.
Place: England
PMID: 34185935},
keywords = {antibiotic resistance, bacteria, febrile children},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: Antibiotics efficacy is severely threatened due to
emerging resistance worldwide, but there is a paucity of
antibiotics efficacy data for the West African region in
general. Therefore, this study aimed to determine the antibiotic
susceptibility profile of bacterial isolated from febrile
children under 5 years of age in Nanoro (Burkina Faso). METHODS:
Blood, stool and urine samples were collected from 1099 febrile
children attending peripheral health facilities and the referral
hospital in Nanoro Health district. Bacterial isolates from
these samples were assessed for their susceptibility against
commonly used antibiotics by Kirby-Bauer method. RESULTS: In
total, 141 bacterial isolates were recovered from 127 febrile
children of which 65 from blood, 65 from stool and 11 from
urine. Salmonella isolates were most frequently isolated and
found to be highly resistant to ampicillin (70%; 56/80) and
trimethoprim-sulphamethoxazole (65%; 52/80). Escherichia coli
isolates showed a high resistance rate to
trimethoprim-sulphamethoxazole (100%), ampicillin (100%),
ciprofloxacin (71.4%; 10/14), amoxicillin-clavulanate (64.3%;
9/14), ceftriaxone (64.3%; 9/14) and gentamycin (50%; 7/14).
Moreover, half of the E. coli isolates produced ß-lactamase
suggesting multi-drug resistance against $beta$-lactam as well
as non-$beta$-lactam antibiotics. Multi-drug resistance was
observed in 54.6% (59/108) of the isolates, mainly
Gram-negative bacteria. CONCLUSIONS: This study showed high
resistance rates to common antibiotics used to treat bacterial
infections in Nanoro. The work prompts the need to expand
antibiotic resistance surveillance studies in Burkina Faso. |
 | Palpouguini Lompo, Marc Christian Tahita, Hermann Sorgho, William Kaboré, Adama Kazienga, Ashmed Cheick Bachirou Nana, Hamtandi Magloire Natama, Isidore Juste Ouindgueta Bonkoungou, Nicolas Barro, Halidou Tinto Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso (Journal Article) In: Pan Afr. Med. J., vol. 38, pp. 259, 2021, ISSN: 1937-8688, (Copyright: Palpouguini Lompo et al.
PMID: 34104307
PMCID: PMC8164431). @article{Lompo2021-sk,
title = {Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso},
author = {Palpouguini Lompo and Marc Christian Tahita and Hermann Sorgho and William Kabor\'{e} and Adama Kazienga and Ashmed Cheick Bachirou Nana and Hamtandi Magloire Natama and Isidore Juste Ouindgueta Bonkoungou and Nicolas Barro and Halidou Tinto},
doi = {10.11604/pamj.2021.38.259.15864},
issn = {1937-8688},
year = {2021},
date = {2021-03-01},
urldate = {2021-03-01},
journal = {Pan Afr. Med. J.},
volume = {38},
pages = {259},
publisher = {Pan African Medical Journal},
abstract = {INTRODUCTION: acute diarrhea in children under five years is a public health problem in developing countries and particularly in malaria-endemic areas where both diseases co-exist. The present study examined the etiology of childhood diarrhea and its comorbidity with malaria in a rural area of Burkina Faso.
METHODS: conventional culture techniques, direct stools examination, and viruses´ detection by rapid tests were performed on the fresh stools and microscopy was used to diagnose malaria. Some risk factors were also assessed. RESULTS: on a total of 191 samples collected, at least one pathogen was identified in 89 cases (46.6%). The proportions of pathogens found on the 89 positive stool samples were parasites 51.69% (46 cases), viruses 39.33% (35 cases), and bacteria 14.61% (13 cases), respectively. The relationship between malaria and infectious diarrhea was significant in viral and parasites causes (p=0.005 and 0.043 respectively). Fever, vomiting and abdominal pain were the major symptoms associated with diarrhea, with 71.51%, 31.72% and 23.66% respectively. The highest viral diarrhea prevalence was reported during the dry season (OR=5.29, 95% CI: 1.74 - 16.07, p=0.001) while parasite diarrhea was more encountered during the rainy season (OR=0.41, 95% CI: 0.33 - 0.87, p=0.011). CONCLUSION: Giardia spp and rotavirus were the leading cause of acute diarrhea in Nanoro, Burkina Faso with a predominance of rotavirus in children less than 2 years. Parasite and viral diarrhea were the most pathogens associated with malaria. However, the high rate of negative stool samples suggests the need to determine other enteric microorganisms.},
note = {Copyright: Palpouguini Lompo et al.
PMID: 34104307
PMCID: PMC8164431},
keywords = {Abdominal Pain/epidemiology, Acute Disease, bacteria, Burkina Faso, Burkina Faso/epidemiology, Child, Comorbidity, Diarrhea, Diarrhea/epidemiology/microbiology, Female, Fever/epidemiology, Giardiasis/epidemiology, Humans, Infant, infectious, Malaria, Malaria/epidemiology, Male, parasite, pathogens, Preschool, Prevalence, Risk Factors, rotavirus, Rotavirus Infections/epidemiology, Rural Population, Seasons, Vomiting/epidemiology},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: acute diarrhea in children under five years is a public health problem in developing countries and particularly in malaria-endemic areas where both diseases co-exist. The present study examined the etiology of childhood diarrhea and its comorbidity with malaria in a rural area of Burkina Faso.
METHODS: conventional culture techniques, direct stools examination, and viruses´ detection by rapid tests were performed on the fresh stools and microscopy was used to diagnose malaria. Some risk factors were also assessed. RESULTS: on a total of 191 samples collected, at least one pathogen was identified in 89 cases (46.6%). The proportions of pathogens found on the 89 positive stool samples were parasites 51.69% (46 cases), viruses 39.33% (35 cases), and bacteria 14.61% (13 cases), respectively. The relationship between malaria and infectious diarrhea was significant in viral and parasites causes (p=0.005 and 0.043 respectively). Fever, vomiting and abdominal pain were the major symptoms associated with diarrhea, with 71.51%, 31.72% and 23.66% respectively. The highest viral diarrhea prevalence was reported during the dry season (OR=5.29, 95% CI: 1.74 – 16.07, p=0.001) while parasite diarrhea was more encountered during the rainy season (OR=0.41, 95% CI: 0.33 – 0.87, p=0.011). CONCLUSION: Giardia spp and rotavirus were the leading cause of acute diarrhea in Nanoro, Burkina Faso with a predominance of rotavirus in children less than 2 years. Parasite and viral diarrhea were the most pathogens associated with malaria. However, the high rate of negative stool samples suggests the need to determine other enteric microorganisms. |
