Publications

@article{Lompo2023,

title = {Growth of Gram-Negative Bacteria in Antiseptics, Disinfectants and Hand Hygiene Products in Two Tertiary Care Hospitals in West Africa\textemdashA Cross-Sectional Survey},

author = {Palpouguini Lompo and Anne Sophie Heroes and Esenam Agbobli and Adama Kazienga and Marjan Peeters and Halidou Tinto and Katrien Lagrou and Lassana Sangar\'{e} and Dissou Affolabi and Jan Jacobs},

url = {https://www.mdpi.com/2076-0817/12/7/917/htm https://www.mdpi.com/2076-0817/12/7/917},

doi = {10.3390/PATHOGENS12070917/S1},

issn = {20760817},

year  = {2023},

date = {2023-01-01},

journal = {Pathogens},

volume = {12},

issue = {7},

pages = {917},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

abstract = {Antiseptics, disinfectants, and hand hygiene products can act as reservoirs of Gram-negative bacteria causing healthcare-associated infections. This problem is rarely documented in low- and middle-income countries, particularly in sub-Saharan Africa. In a cross-sectional survey, we assessed the bacterial contamination of antiseptics, disinfectants, and hand hygiene products in two university hospitals in Burkina Faso and Benin. During ward visits and staff interviews, in-use products were cultured for the presence of Gram-negative bacteria. The growth of Gram-negative bacteria was absent or rare in alcohol-based products, povidone iodine, and Dakin solution. Contamination was highest (73.9% (51/69)) for liquid soap products (versus antiseptic/disinfectants (4.5%, 7/157) (p \< 0.0001)), mostly used in high-risk areas and associated with high total bacterial counts (\>10,000 colony-forming units/mL). Contaminating flora (105 isolates) included Enterobacterales and the Vibrio non-cholerae/Aeromonas group (17.1%) and non-fermentative Gram-negative rods (82.8%). Multidrug resistance was present among 9/16 Enterobacterales (Klebsiella and Enterobacter spp.) and 3/12 Acinetobacter spp., including carbapenem resistance (Acinetobacter baumannii: NDM, Pseudomonas stutzeri: VIM). The risk factors for contamination included the type of product (cleaning grade and in-house prepared liquid soap), use of recycled disposable containers and soft drink bottles, absence of labeling, topping-up of containers, dilution with tap water (pharmacy and ward), and poor-quality management (procurement, stock management, expiry dates, and period after opening).},

keywords = {antiseptics, bacteria, cross-sectional, disinfectants, Gram-negative, hand hygiene, healthcare-associated infections, low-and middle-income countries, resistance, West Africa},

pubstate = {published},

tppubtype = {article}

}

@article{Adoke2021-el,

title = {A randomized, double-blind, phase 2b study to investigate the  efficacy, safety, tolerability and pharmacokinetics of a  single-dose regimen of ferroquine with artefenomel in adults and  children with uncomplicated Plasmodium falciparum malaria},

author = {Yeka Adoke and Rella Zoleko-Manego and Serge Ouoba and Alfred B Tiono and Grace Kaguthi and Juv^encio Eduardo Bonzela and Tran Thanh Duong and Alain Nahum and Marielle Bouyou-Akotet and Bernhards Ogutu and Alphonse Ouedraogo and Fiona Macintyre and Andreas Jessel and Bart Laurijssens and Mohammed H Cherkaoui-Rbati and Cathy Cantalloube and Anne Claire Marrast and Rapha"el Bejuit and David White and Timothy N C Wells and Florian Wartha and Didier Leroy and Afizi Kibuuka and Ghyslain Mombo-Ngoma and Daouda Ouattara and Ir`ene Mugenya and Bui Quang Phuc and Francis Bohissou and Denise P Mawili-Mboumba and Fredrick Olewe and Issiaka Soulama and Halidou Tinto and FALCI Study Group},

doi = {10.1186/s12936-021-03749-4},

issn = {1475-2875},

year  = {2021},

date = {2021-05-19},

urldate = {2021-05-19},

journal = {Malar. J.},

volume = {20},

number = {1},

pages = {222},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: For uncomplicated Plasmodium falciparum malaria, 

 highly efficacious single-dose treatments are expected to 

 increase compliance and improve treatment outcomes, and thereby 

 may slow the development of resistance. The efficacy and safety 

 of a single-dose combination of artefenomel (800 mg) plus 

 ferroquine (400/600/900/1200 mg doses) for the treatment of 

 uncomplicated P. falciparum malaria were evaluated in Africa 

 (focusing on children $\leq$ 5 years) and Asia. METHODS: The 

 study was a randomized, double-blind, single-dose, multi-arm 

 clinical trial in patients aged \> 6 months to 5 years and 20 

 Asian patients. None of the treatment arms met the target 

 efficacy criterion for PCR-adjusted ACPR at Day 28 (lower limit 

 of 95% confidence interval [CI] \> 90%). PCR-adjusted ACPR at 

 Day 28 [95% CI] in the PP Set ranged from 78.4% [64.7; 88.7%] 

 to 91.7% [81.6; 97.2%] for the 400 mg to 1200 mg ferroquine 

 dose. Efficacy rates were low in Vietnamese patients, ranging 

 from 20 to 40%. A clear relationship was found between drug 

 exposure (artefenomel and ferroquine concentrations at Day 7) 

 and efficacy (primary endpoint), with higher concentrations of 

 both drugs resulting in higher efficacy. Six distinct kelch-13 

 mutations were detected in parasite isolates from 10/272 African 

 patients (with 2 mutations known to be associated with 

 artemisinin resistance) and 18/20 Asian patients (all C580Y 

 mutation). Vomiting within 6 h of initial artefenomel 

 administration was common (24.6%) and associated with lower 

 drug exposures. CONCLUSION: The efficacy of 

 artefenomel/ferroquine combination was suboptimal in African 

 children aged $\leq$ 5 years, the population of interest, and 

 vomiting most likely had a negative impact on efficacy. Trial 

 registration ClinicalTrials.gov, NCT02497612. Registered 14 Jul 

 2015, https://clinicaltrials.gov/ct2/show/NCT02497612?term=NCT02497612\&draw=2\&rank=1.},

note = {PMID: 34011358 

PMCID: PMC8135182},

keywords = {Adamantane/administration \& dosage/analogs \& derivatives, Adolescent, Adult, Aged, Aminoquinolines/administration \& dosage, Benin, Burkina Faso, C580Y, Child, Combination treatment, Double-Blind Method, Drug Combinations, Exposure\textendashresponse, Falciparum/prevention \& control, Female, Ferroquine, Ferrous Compounds/administration \& dosage, Gabon, Humans, Infant, Kelch-13 mutation, Kenya, Malaria, Male, Metallocenes/administration \& dosage, Middle Aged, Mozambique, Parasite clearance, Peroxides/administration \& dosage, Pharmacokinetics/pharmacodynamics, Plasmodium falciparum/drug effects, Preschool, resistance, Uganda, Vietnam, Vomiting, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{Bonko2021-kv,

title = {Antibiotic susceptibility of Staphylococcus aureus and  Streptococcus pneumoniae isolates from the nasopharynx of febrile  children under 5 years in Nanoro, Burkina Faso},

author = {Massa Dit Achille Bonko and Palpouguini Lompo and Marc Christian Tahita and Francois Kiemde and Ibrahima Karama and Athanase M Som\'{e} and Petra F Mens and Sandra Menting and Halidou Tinto and Henk D F H Schallig},

doi = {10.3390/antibiotics10040444},

issn = {2079-6382},

year  = {2021},

date = {2021-04-15},

urldate = {2021-04-15},

journal = {Antibiotics (Basel)},

volume = {10},

number = {4},

abstract = {(1) Background: nasopharynx colonization by resistant 

 Staphylococcus aureus and Streptococcus pneumoniae can lead to 

 serious diseases. Emerging resistance to antibiotics commonly 

 used to treat infections due to these pathogens poses a serious 

 threat to the health system. The present study aimed to determine 

 the antibiotic susceptibility of S. aureus and S. pneumoniae 

 isolates from the febrile children's nasopharynx under 5 years in 

 Nanoro (Burkina Faso). (2) Methods: bacterial isolates were 

 identified from nasopharyngeal swabs prospectively collected from 

 629 febrile children. Antibiotic susceptibility of S. aureus and 

 S. pneumoniae isolates was assessed by Kirby-Bauer method and 

 results were interpreted according to the Clinical and Laboratory 

 Standard Institute guidelines. (3) Results: bacterial 

 colonization was confirmed in 154 (24.5%) of children of whom 

 96.1% carried S. aureus, 3.2% had S. pneumoniae, and 0.6% 

 carried both bacteria. S. aureus isolates showed alarming 

 resistance to penicillin (96.0%) and S. pneumoniae was highly 

 resistant to tetracycline (100%) and 

 trimethoprim-sulfamethoxazole (83.3%), and moderately resistant 

 to penicillin (50.0%). Furthermore, 4.0% of S. aureus 

 identified were methicillin resistant. (4) Conclusion: this study 

 showed concerning resistance rates to antibiotics to treat 

 suspected bacterial respiratory tract infections. The work 

 highlights the necessity to implement continuous antibiotic 

 resistance surveillance.},

note = {PMID: 33920987 

PMCID: PMC8071235},

keywords = {antibiotics, children; nasopharynx, resistance, Staphylococcus aureus, Streptococcus pneumoniae},

pubstate = {published},

tppubtype = {article}

}