2022
|
Journal Articles
|
| Silene Casari, Monica Di Paola, Elena Banci, Salou Diallo, Luca Scarallo, Sara Renzo, Agnese Gori, Sonia Renzi, Monica Paci, Quirijn Mast, Tal Pecht, Karim Derra, Berenger Kaboré, Halidou Tinto, Duccio Cavalieri, Paolo Lionetti Changing Dietary Habits: The Impact of Urbanization and Rising Socio-Economic Status in Families from Burkina Faso in Sub-Saharan Africa. (Journal Article) In: Nutrients, vol. 14, iss. 9, 2022, ISSN: 2072-6643. @article{nokey,
title = {Changing Dietary Habits: The Impact of Urbanization and Rising Socio-Economic Status in Families from Burkina Faso in Sub-Saharan Africa.},
author = {Silene Casari and Monica Di Paola and Elena Banci and Salou Diallo and Luca Scarallo and Sara Renzo and Agnese Gori and Sonia Renzi and Monica Paci and Quirijn Mast and Tal Pecht and Karim Derra and Berenger Kabor\'{e} and Halidou Tinto and Duccio Cavalieri and Paolo Lionetti},
doi = {10.3390/nu14091782},
issn = {2072-6643},
year = {2022},
date = {2022-04-01},
urldate = {2022-04-01},
journal = {Nutrients},
volume = {14},
issue = {9},
abstract = {(1) Background: Sub-Saharan Africa is experiencing the fastest urbanization worldwide. People in rural areas still have a traditional and rural lifestyle, whereas the Westernization of diet and lifestyle is already evident in urban areas. This study describes dietary habits of families in Burkina Faso living at different levels of urbanization. (2) Methods: Data on lifestyle, socio-economic conditions, health status and anthropometry were collected from 30 families living in rural villages, a small town and the capital city. A food frequency questionnaire and a 24 h recall diary were used to estimate dietary habits and macronutrients intake. (3) Results: The urban cohort showed a more diversified diet, with a higher intake of animal protein and, especially in children, a higher consumption of simple sugars. Fiber intake was significantly higher in the rural and semi-urbanized cohorts. As expected, overweight and obesity gradually increased with the level of urbanization. In semi-urbanized and urban families, we observed coexistence of under- and over-nutrition, whereas in rural families, a portion of children were wasted and stunted, and adults were underweight. (4) Conclusions: These three cohorts represent a model of the effect on diet of rural-to-urban migration. Rural diet and traditional habits are replaced by a Western-oriented diet when families move to urbanized areas. This dietary transition and increased socio-economic status in newly developing urban areas have a major impact on disease epidemiology, resembling the past evolution in Western countries.},
keywords = {*Economic Status, *Urbanization, Burkina Faso, Burkina Faso/epidemiology, Feeding Behavior, fiber intake, Humans, rural diet, Rural Population, sub-Saharan Africa, Urban Population, urbanization, Western diet},
pubstate = {published},
tppubtype = {article}
}
(1) Background: Sub-Saharan Africa is experiencing the fastest urbanization worldwide. People in rural areas still have a traditional and rural lifestyle, whereas the Westernization of diet and lifestyle is already evident in urban areas. This study describes dietary habits of families in Burkina Faso living at different levels of urbanization. (2) Methods: Data on lifestyle, socio-economic conditions, health status and anthropometry were collected from 30 families living in rural villages, a small town and the capital city. A food frequency questionnaire and a 24 h recall diary were used to estimate dietary habits and macronutrients intake. (3) Results: The urban cohort showed a more diversified diet, with a higher intake of animal protein and, especially in children, a higher consumption of simple sugars. Fiber intake was significantly higher in the rural and semi-urbanized cohorts. As expected, overweight and obesity gradually increased with the level of urbanization. In semi-urbanized and urban families, we observed coexistence of under- and over-nutrition, whereas in rural families, a portion of children were wasted and stunted, and adults were underweight. (4) Conclusions: These three cohorts represent a model of the effect on diet of rural-to-urban migration. Rural diet and traditional habits are replaced by a Western-oriented diet when families move to urbanized areas. This dietary transition and increased socio-economic status in newly developing urban areas have a major impact on disease epidemiology, resembling the past evolution in Western countries. |
| Biébo Bihoun, Serge Henri Zango, Maminata Traoré-Coulibaly, Innocent Valea, Raffaella Ravinetto, Jean Pierre Van Geertruyden, Umberto D’Alessandro, Halidou Tinto, Annie Robert Age-modified factors associated with placental malaria in rural Burkina Faso. (Journal Article) In: BMC pregnancy and childbirth, vol. 22, iss. 1, pp. 248, 2022, ISSN: 1471-2393. @article{nokey,
title = {Age-modified factors associated with placental malaria in rural Burkina Faso.},
author = {Bi\'{e}bo Bihoun and Serge Henri Zango and Maminata Traor\'{e}-Coulibaly and Innocent Valea and Raffaella Ravinetto and Jean Pierre Van Geertruyden and Umberto D'Alessandro and Halidou Tinto and Annie Robert},
doi = {10.1186/s12884-022-04568-4},
issn = {1471-2393},
year = {2022},
date = {2022-03-01},
urldate = {2022-03-01},
journal = {BMC pregnancy and childbirth},
volume = {22},
issue = {1},
pages = {248},
abstract = {BACKGROUND: Malaria in pregnancy can result in placental infection with fetal implications. This study aimed at assessing placental malaria (PM) prevalence and its associated factors in a cohort of pregnant women with peripheral malaria and their offspring. METHOD: The data were collected in the framework of a clinical trial on treatments for malaria in pregnant women . Placental malaria (PM) was diagnosed by histopathological detection of parasites and/or malaria pigment on placenta biopsies taken at delivery. Factors associated with PM were assessed using logistic regression. RESULTS: Out of 745 biopsies examined, PM was diagnosed in 86.8 % of women. Acute, chronic and past PM were retrieved in 11 (1.5 %), 170 (22.8 %), and 466 (62.6 %) women, respectively. A modifying effect was observed in the association of gravidity or anemia at the study start with pooled PM (presence of parasites and/or malaria pigment). In women under 30, gravidity ≤ 2 was associated with an increased prevalence of pooled PM but in women aged 30 years or more, gravidity was no more associated with pooled PM (OR 6.81, 95 % CI 3.18 - 14.60; and OR 0.52, 95 % CI 0.10 - 2.76, respectively). Anemia was associated with pooled PM in women under 30 (OR 1.96, 95 % CI 1.03 - 3.72) but not in women aged 30 years or more (OR 0.68, 95 % CI 0.31 - 1.49). Similarly, the association of gravidity with past-chronic PM depended also on age. A higher prevalence of active PM was observed in women under 30 presenting with symptomatic malaria (OR 3.79, 95 % CI 1.55 - 9.27), while there was no significant increase in the prevalence of active PM (presence of parasites only) in women with symptomatic malaria when aged 30 years or more (OR 0.42, 95 % CI 0.10 - 1.75). In women with chronic PM, the prevalence of low birth weight or prematurity was the highest (31.2 %) as compared with past PM or no PM. CONCLUSION: Despite the rapid diagnosis and efficacious treatment of peripheral infection, the prevalence of placental malaria remained high in women with P. falciparum peripheral infection in Nanoro, especially in younger women This underlines the importance of preventive measures in this specific group.},
keywords = {*Malaria, *Malaria/epidemiology, Adult, Burkina Faso, Burkina Faso/epidemiology, Falciparum/parasitology, Female, Gravidity, Humans, Malaria, placenta, Placenta/parasitology, Pregnancy, Risk Factors},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria in pregnancy can result in placental infection with fetal implications. This study aimed at assessing placental malaria (PM) prevalence and its associated factors in a cohort of pregnant women with peripheral malaria and their offspring. METHOD: The data were collected in the framework of a clinical trial on treatments for malaria in pregnant women . Placental malaria (PM) was diagnosed by histopathological detection of parasites and/or malaria pigment on placenta biopsies taken at delivery. Factors associated with PM were assessed using logistic regression. RESULTS: Out of 745 biopsies examined, PM was diagnosed in 86.8 % of women. Acute, chronic and past PM were retrieved in 11 (1.5 %), 170 (22.8 %), and 466 (62.6 %) women, respectively. A modifying effect was observed in the association of gravidity or anemia at the study start with pooled PM (presence of parasites and/or malaria pigment). In women under 30, gravidity ≤ 2 was associated with an increased prevalence of pooled PM but in women aged 30 years or more, gravidity was no more associated with pooled PM (OR 6.81, 95 % CI 3.18 – 14.60; and OR 0.52, 95 % CI 0.10 – 2.76, respectively). Anemia was associated with pooled PM in women under 30 (OR 1.96, 95 % CI 1.03 – 3.72) but not in women aged 30 years or more (OR 0.68, 95 % CI 0.31 – 1.49). Similarly, the association of gravidity with past-chronic PM depended also on age. A higher prevalence of active PM was observed in women under 30 presenting with symptomatic malaria (OR 3.79, 95 % CI 1.55 – 9.27), while there was no significant increase in the prevalence of active PM (presence of parasites only) in women with symptomatic malaria when aged 30 years or more (OR 0.42, 95 % CI 0.10 – 1.75). In women with chronic PM, the prevalence of low birth weight or prematurity was the highest (31.2 %) as compared with past PM or no PM. CONCLUSION: Despite the rapid diagnosis and efficacious treatment of peripheral infection, the prevalence of placental malaria remained high in women with P. falciparum peripheral infection in Nanoro, especially in younger women This underlines the importance of preventive measures in this specific group. |
| Moussa Lingani, Serge Henri Zango, Innocent Valéa, Georges Somé, Maïmouna Sanou, Sékou O. Samadoulougou, Serge Ouoba, Eli Rouamba, Annie Robert, Michèle Dramaix, Philippe Donnen, Halidou Tinto Low birth weight and its associated risk factors in a rural health district of Burkina Faso: a cross sectional study. (Journal Article) In: BMC pregnancy and childbirth, vol. 22, iss. 1, pp. 228, 2022, ISSN: 1471-2393. @article{nokey,
title = {Low birth weight and its associated risk factors in a rural health district of Burkina Faso: a cross sectional study.},
author = {Moussa Lingani and Serge Henri Zango and Innocent Val\'{e}a and Georges Som\'{e} and Ma\"{i}mouna Sanou and S\'{e}kou O. Samadoulougou and Serge Ouoba and Eli Rouamba and Annie Robert and Mich\`{e}le Dramaix and Philippe Donnen and Halidou Tinto},
doi = {10.1186/s12884-022-04554-w},
issn = {1471-2393},
year = {2022},
date = {2022-03-01},
urldate = {2022-03-01},
journal = {BMC pregnancy and childbirth},
volume = {22},
issue = {1},
pages = {228},
abstract = {BACKGROUND: Low birth weight (LBW) is a major factor of neonate mortality that particularly affects developing countries. However, the scarcity of data to support decision making to reduce LBW occurrence is a major obstacle in sub-Saharan Africa. The aim of this research was to determine the prevalence and associated factors of LBW at the Yako health district in a rural area of Burkina Faso. METHODS: A cross sectional survey was conducted at four peripheral health centers among mothers and their newly delivered babies. The mothers' socio-demographic and obstetrical characteristics were collected by face-to-face interview or by review of antenatal care books. Maternal malaria was tested by standard microscopy and neonates' birth weights were documented. Multivariate logistic regression was used to determine factors associated with LBW. A p-value \< 0.05 was considered statistically significant. RESULTS: Of 600 neonates examined, the prevalence of low birth weight was 11.0%. Adjustment for socio-demographic characteristic, medical conditions, obstetrical history, malaria prevention measures by multivariate logistic regression found that being a primigravid mother (aOR = 1.8, [95% CI: 1.1-3.0]), the presence of malaria infection (aOR = 1.9, [95% CI: 1.1-3.5]), the uptake of less than three doses of sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy (IPTp-SP) (aOR = 2.2, [95% CI: 1.3-3.9]), the presence of maternal fever at the time of delivery (aOR = 2.8, [95% CI: 1.5-5.3]) and being a female neonate (aOR = 1.9, [95% CI: 1.1-3.3]) were independently associated with an increased risk of LBW occurrence. The number of antenatal visits performed by the mother during her pregnancy did not provide any direct protection for low birth weight. CONCLUSION: The prevalence of LBW remained high in the study area. Maternal malaria, fever and low uptake of sulfadoxine-pyrimethamine doses were significantly associated with LBW and should be adequately addressed by public health interventions.},
keywords = {*Antimalarials/therapeutic use, *Rural Health, Associated factors, Burkina Faso, Burkina Faso/epidemiology, Cross-Sectional Studies, Female, Humans, Infant, Low Birth Weight, Newborn, Pregnancy, Risk Factors, Rural area},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Low birth weight (LBW) is a major factor of neonate mortality that particularly affects developing countries. However, the scarcity of data to support decision making to reduce LBW occurrence is a major obstacle in sub-Saharan Africa. The aim of this research was to determine the prevalence and associated factors of LBW at the Yako health district in a rural area of Burkina Faso. METHODS: A cross sectional survey was conducted at four peripheral health centers among mothers and their newly delivered babies. The mothers’ socio-demographic and obstetrical characteristics were collected by face-to-face interview or by review of antenatal care books. Maternal malaria was tested by standard microscopy and neonates’ birth weights were documented. Multivariate logistic regression was used to determine factors associated with LBW. A p-value < 0.05 was considered statistically significant. RESULTS: Of 600 neonates examined, the prevalence of low birth weight was 11.0%. Adjustment for socio-demographic characteristic, medical conditions, obstetrical history, malaria prevention measures by multivariate logistic regression found that being a primigravid mother (aOR = 1.8, [95% CI: 1.1-3.0]), the presence of malaria infection (aOR = 1.9, [95% CI: 1.1-3.5]), the uptake of less than three doses of sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy (IPTp-SP) (aOR = 2.2, [95% CI: 1.3-3.9]), the presence of maternal fever at the time of delivery (aOR = 2.8, [95% CI: 1.5-5.3]) and being a female neonate (aOR = 1.9, [95% CI: 1.1-3.3]) were independently associated with an increased risk of LBW occurrence. The number of antenatal visits performed by the mother during her pregnancy did not provide any direct protection for low birth weight. CONCLUSION: The prevalence of LBW remained high in the study area. Maternal malaria, fever and low uptake of sulfadoxine-pyrimethamine doses were significantly associated with LBW and should be adequately addressed by public health interventions. |
2021
|
Journal Articles
|
| Serge Ouoba, Jean Claude Romaric Pingdwinde Ouedraogo, Moussa Lingani, Bunthen E, Md Razeen Ashraf Hussain, Ko Ko, Shintaro Nagashima, Aya Sugiyama, Tomoyuki Akita, Halidou Tinto, Junko Tanaka Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis (Journal Article) In: BMC Infect. Dis., vol. 21, no. 1, pp. 1126, 2021, ISSN: 1471-2334, (© 2021. The Author(s).
PMID: 34724902
PMCID: PMC8561994). @article{Ouoba2021-ug,
title = {Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis},
author = {Serge Ouoba and Jean Claude Romaric Pingdwinde Ouedraogo and Moussa Lingani and Bunthen E and Md Razeen Ashraf Hussain and Ko Ko and Shintaro Nagashima and Aya Sugiyama and Tomoyuki Akita and Halidou Tinto and Junko Tanaka},
doi = {10.1186/s12879-021-06817-x},
issn = {1471-2334},
year = {2021},
date = {2021-11-01},
urldate = {2021-11-01},
journal = {BMC Infect. Dis.},
volume = {21},
number = {1},
pages = {1126},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Detailed characteristics of Hepatitis C virus (HCV)
infection in Burkina Faso are scarce. The main aim of this study
was to assess HCV seroprevalence in various settings and
populations at risk in Burkina Faso between 1990 and 2020.
Secondary objectives included the prevalence of HCV Ribonucleic
acid (RNA) and the distribution of HCV genotypes. METHODS: A
systematic database search, supplemented by a manual search, was
conducted in PubMed, Web of Science, Scopus, and African Index
Medicus. Studies reporting HCV seroprevalence data in low and
high-risk populations in Burkina Faso were included, and a
random-effects meta-analysis was applied. Risk of bias was
assessed using the Joanna Briggs institute checklist. RESULTS:
Low-risk populations were examined in 31 studies involving a
total of 168,151 subjects, of whom 8330 were positive for HCV
antibodies. Six studies included a total of 1484 high-risk
persons, and 96 had antibodies to HCV. The pooled seroprevalence
in low-risk populations was 3.72% (95% CI: 3.20-4.28) and
4.75% (95% CI: 1.79-8.94) in high-risk groups. A
non-significant decreasing trend was observed over the study
period. Seven studies tested HCV RNA in a total of 4759
individuals at low risk for HCV infection, and 81 were positive.
The meta-analysis of HCV RNA yielded a pooled prevalence of
1.65% (95% CI: 0.74-2.89%) in low-risk populations, which is
assumed to be indicative of HCV prevalence in the general
population of Burkina Faso and suggests that about 301,174
people are active HCV carriers in the country. Genotypes 2 and 1
were the most frequent, with 60.3% and 25.0%, respectively.
CONCLUSIONS: HCV seroprevalence is intermediate in Burkina Faso
and indicates the need to implement effective control
strategies. There is a paucity of data at the national level and
for rural and high-risk populations. General population
screening and linkage to care are recommended, with special
attention to rural and high-risk populations.},
note = {© 2021. The Author(s).
PMID: 34724902
PMCID: PMC8561994},
keywords = {Burkina Faso, Burkina Faso/epidemiology, Genotype, Hepacivirus/genetics, Hepatitis C, Hepatitis C/epidemiology, Humans, Prevalence, Seroepidemiologic Studies, Seroprevalence, Systematic review},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Detailed characteristics of Hepatitis C virus (HCV)
infection in Burkina Faso are scarce. The main aim of this study
was to assess HCV seroprevalence in various settings and
populations at risk in Burkina Faso between 1990 and 2020.
Secondary objectives included the prevalence of HCV Ribonucleic
acid (RNA) and the distribution of HCV genotypes. METHODS: A
systematic database search, supplemented by a manual search, was
conducted in PubMed, Web of Science, Scopus, and African Index
Medicus. Studies reporting HCV seroprevalence data in low and
high-risk populations in Burkina Faso were included, and a
random-effects meta-analysis was applied. Risk of bias was
assessed using the Joanna Briggs institute checklist. RESULTS:
Low-risk populations were examined in 31 studies involving a
total of 168,151 subjects, of whom 8330 were positive for HCV
antibodies. Six studies included a total of 1484 high-risk
persons, and 96 had antibodies to HCV. The pooled seroprevalence
in low-risk populations was 3.72% (95% CI: 3.20-4.28) and
4.75% (95% CI: 1.79-8.94) in high-risk groups. A
non-significant decreasing trend was observed over the study
period. Seven studies tested HCV RNA in a total of 4759
individuals at low risk for HCV infection, and 81 were positive.
The meta-analysis of HCV RNA yielded a pooled prevalence of
1.65% (95% CI: 0.74-2.89%) in low-risk populations, which is
assumed to be indicative of HCV prevalence in the general
population of Burkina Faso and suggests that about 301,174
people are active HCV carriers in the country. Genotypes 2 and 1
were the most frequent, with 60.3% and 25.0%, respectively.
CONCLUSIONS: HCV seroprevalence is intermediate in Burkina Faso
and indicates the need to implement effective control
strategies. There is a paucity of data at the national level and
for rural and high-risk populations. General population
screening and linkage to care are recommended, with special
attention to rural and high-risk populations. |
| Mphatso Dennis Phiri, Matthew Cairns, Issaka Zongo, Frederic Nikiema, Modibo Diarra, Rakiswendé Serge Yerbanga, Amadou Barry, Amadou Tapily, Samba Coumare, Ismaila Thera, Irene Kuepfer, Paul Milligan, Halidou Tinto, Alassane Dicko, Jean Bosco Ouédraogo, Brian Greenwood, Daniel Chandramohan, Issaka Sagara The duration of protection from azithromycin against malaria, acute respiratory, gastrointestinal, and skin infections when given alongside seasonal malaria chemoprevention: Secondary analyses of data from a clinical trial in houndé, Burkina Faso, and bougouni, Mali (Journal Article) In: Clin. Infect. Dis., vol. 73, no. 7, pp. e2379–e2386, 2021, ISSN: 1537-6591 1058-4838, (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
PMID: 33417683
PMCID: PMC8492219). @article{Phiri2021-oy,
title = {The duration of protection from azithromycin against malaria, acute respiratory, gastrointestinal, and skin infections when given alongside seasonal malaria chemoprevention: Secondary analyses of data from a clinical trial in hound\'{e}, Burkina Faso, and bougouni, Mali},
author = {Mphatso Dennis Phiri and Matthew Cairns and Issaka Zongo and Frederic Nikiema and Modibo Diarra and Rakiswend\'{e} Serge Yerbanga and Amadou Barry and Amadou Tapily and Samba Coumare and Ismaila Thera and Irene Kuepfer and Paul Milligan and Halidou Tinto and Alassane Dicko and Jean Bosco Ou\'{e}draogo and Brian Greenwood and Daniel Chandramohan and Issaka Sagara},
doi = {10.1093/cid/ciaa1905},
issn = {1537-6591 1058-4838},
year = {2021},
date = {2021-10-01},
urldate = {2021-10-01},
journal = {Clin. Infect. Dis.},
volume = {73},
number = {7},
pages = {e2379--e2386},
publisher = {Oxford University Press (OUP)},
abstract = {BACKGROUND: Mass drug administration (MDA) with azithromycin
(AZ) is being considered as a strategy to promote child survival
in sub-Saharan Africa, but the mechanism by which AZ reduces
mortality is unclear. To better understand the nature and extent
of protection provided by AZ, we explored the profile of
protection by time since administration, using data from a
household-randomized, placebo-controlled trial in Burkina Faso
and Mali. METHODS: Between 2014 and 2016, 30 977 children aged
3-59 months received seasonal malaria chemoprevention (SMC) with
sulfadoxine-pyrimethamine plus amodiaquine and either AZ or
placebo monthly, on 4 occasions each year. Poisson regression
with gamma-distributed random effects, accounting for the
household randomization and within-individual clustering of
illness episodes, was used to compare incidence of prespecified
outcomes between SMC+AZ versus SMC+placebo groups in fixed time
strata post-treatment. The likelihood ratio test was used to
assess evidence for a time-treatment group interaction. RESULTS:
Relative to SMC+placebo, there was no evidence of protection
from SMC+AZ against hospital admissions and deaths. Additional
protection from SMC+AZ against malaria was confined to the first
2 weeks post-administration (protective efficacy (PE): 24.2%
[95% CI: 17.8%, 30.1%]). Gastroenteritis and pneumonia were
reduced by 29.9% [21.7; 37.3%], and 34.3% [14.9; 49.3%],
respectively, in the first 2 weeks postadministration.
Protection against nonmalaria fevers with a skin condition
persisted up to 28 days: PE: 46.3% [35.1; 55.6%]. CONCLUSIONS:
The benefits of AZ-MDA are broad-ranging but short-lived. To
maximize impact, timing of AZ-MDA must address the challenge of
targeting asynchronous morbidity and mortality peaks from
different causes.},
note = {© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
PMID: 33417683
PMCID: PMC8492219},
keywords = {Antimalarials/therapeutic use, Azithromycin, Azithromycin/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Child, child mortality, Drug Combinations, duration of protection, Humans, Infant, Malaria/drug therapy/epidemiology/prevention \& control, Mali/epidemiology, Preschool, Sahel, seasonal malaria chemoprevention, Seasons},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Mass drug administration (MDA) with azithromycin
(AZ) is being considered as a strategy to promote child survival
in sub-Saharan Africa, but the mechanism by which AZ reduces
mortality is unclear. To better understand the nature and extent
of protection provided by AZ, we explored the profile of
protection by time since administration, using data from a
household-randomized, placebo-controlled trial in Burkina Faso
and Mali. METHODS: Between 2014 and 2016, 30 977 children aged
3-59 months received seasonal malaria chemoprevention (SMC) with
sulfadoxine-pyrimethamine plus amodiaquine and either AZ or
placebo monthly, on 4 occasions each year. Poisson regression
with gamma-distributed random effects, accounting for the
household randomization and within-individual clustering of
illness episodes, was used to compare incidence of prespecified
outcomes between SMC+AZ versus SMC+placebo groups in fixed time
strata post-treatment. The likelihood ratio test was used to
assess evidence for a time-treatment group interaction. RESULTS:
Relative to SMC+placebo, there was no evidence of protection
from SMC+AZ against hospital admissions and deaths. Additional
protection from SMC+AZ against malaria was confined to the first
2 weeks post-administration (protective efficacy (PE): 24.2%
[95% CI: 17.8%, 30.1%]). Gastroenteritis and pneumonia were
reduced by 29.9% [21.7; 37.3%], and 34.3% [14.9; 49.3%],
respectively, in the first 2 weeks postadministration.
Protection against nonmalaria fevers with a skin condition
persisted up to 28 days: PE: 46.3% [35.1; 55.6%]. CONCLUSIONS:
The benefits of AZ-MDA are broad-ranging but short-lived. To
maximize impact, timing of AZ-MDA must address the challenge of
targeting asynchronous morbidity and mortality peaks from
different causes. |
| Daniel Chandramohan, Issaka Zongo, Issaka Sagara, Matthew Cairns, Rakiswendé-Serge Yerbanga, Modibo Diarra, Frédéric Niki`ema, Amadou Tapily, Frédéric Sompougdou, Djibrilla Issiaka, Charles Zoungrana, Koualy Sanogo, Alassane Haro, Mahamadou Kaya, Abdoul-Aziz Sienou, Seydou Traore, Almahamoudou Mahamar, Ismaila Thera, Kalifa Diarra, Amagana Dolo, Irene Kuepfer, Paul Snell, Paul Milligan, Christian Ockenhouse, Opokua Ofori-Anyinam, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouédraogo, Alassane Dicko, Brian Greenwood Seasonal malaria vaccination with or without seasonal malaria chemoprevention (Journal Article) In: N. Engl. J. Med., vol. 385, no. 11, pp. 1005–1017, 2021, ISSN: 1533-4406 0028-4793, (Copyright © 2021 Massachusetts Medical Society.
Place: United States
PMID: 34432975). @article{Chandramohan2021-qm,
title = {Seasonal malaria vaccination with or without seasonal malaria chemoprevention},
author = {Daniel Chandramohan and Issaka Zongo and Issaka Sagara and Matthew Cairns and Rakiswend\'{e}-Serge Yerbanga and Modibo Diarra and Fr\'{e}d\'{e}ric Niki`ema and Amadou Tapily and Fr\'{e}d\'{e}ric Sompougdou and Djibrilla Issiaka and Charles Zoungrana and Koualy Sanogo and Alassane Haro and Mahamadou Kaya and Abdoul-Aziz Sienou and Seydou Traore and Almahamoudou Mahamar and Ismaila Thera and Kalifa Diarra and Amagana Dolo and Irene Kuepfer and Paul Snell and Paul Milligan and Christian Ockenhouse and Opokua Ofori-Anyinam and Halidou Tinto and Abdoulaye Djimde and Jean-Bosco Ou\'{e}draogo and Alassane Dicko and Brian Greenwood},
doi = {10.1056/NEJMoa2026330},
issn = {1533-4406 0028-4793},
year = {2021},
date = {2021-09-09},
urldate = {2021-09-09},
journal = {N. Engl. J. Med.},
volume = {385},
number = {11},
pages = {1005--1017},
publisher = {Massachusetts Medical Society},
abstract = {BACKGROUND: Malaria control remains a challenge in many parts of
the Sahel and sub-Sahel regions of Africa. METHODS: We conducted
an individually randomized, controlled trial to assess whether
seasonal vaccination with RTS,S/AS01E was noninferior to
chemoprevention in preventing uncomplicated malaria and whether
the two interventions combined were superior to either one alone
in preventing uncomplicated malaria and severe malaria-related
outcomes. RESULTS: We randomly assigned 6861 children 5 to 17
months of age to receive sulfadoxine-pyrimethamine and
amodiaquine (2287 children [chemoprevention-alone group]),
RTS,S/AS01E (2288 children [vaccine-alone group]), or
chemoprevention and RTS,S/AS01E (2286 children [combination
group]). Of these, 1965, 1988, and 1967 children in the three
groups, respectively, received the first dose of the assigned
intervention and were followed for 3 years. Febrile seizure
developed in 5 children the day after receipt of the vaccine,
but the children recovered and had no sequelae. There were 305
events of uncomplicated clinical malaria per 1000 person-years
at risk in the chemoprevention-alone group, 278 events per 1000
person-years in the vaccine-alone group, and 113 events per 1000
person-years in the combination group. The hazard ratio for the
protective efficacy of RTS,S/AS01E as compared with
chemoprevention was 0.92 (95% confidence interval [CI], 0.84 to
1.01), which excluded the prespecified noninferiority margin of
1.20. The protective efficacy of the combination as compared
with chemoprevention alone was 62.8% (95% CI, 58.4 to 66.8)
against clinical malaria, 70.5% (95% CI, 41.9 to 85.0) against
hospital admission with severe malaria according to the World
Health Organization definition, and 72.9% (95% CI, 2.9 to
92.4) against death from malaria. The protective efficacy of the
combination as compared with the vaccine alone against these
outcomes was 59.6% (95% CI, 54.7 to 64.0), 70.6% (95% CI,
42.3 to 85.0), and 75.3% (95% CI, 12.5 to 93.0), respectively.
CONCLUSIONS: Administration of RTS,S/AS01E was noninferior to
chemoprevention in preventing uncomplicated malaria. The
combination of these interventions resulted in a substantially
lower incidence of uncomplicated malaria, severe malaria, and
death from malaria than either intervention alone. (Funded by
the Joint Global Health Trials and PATH; ClinicalTrials.gov
number, NCT03143218.).},
note = {Copyright © 2021 Massachusetts Medical Society.
Place: United States
PMID: 34432975},
keywords = {Amodiaquine/therapeutic use, Antimalarials/adverse effects/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Combination, Combined Modality Therapy, Double-Blind Method, Drug Combinations, Drug Therapy, Falciparum/epidemiology/mortality/prevention \& control, Febrile/etiology, Female, Hospitalization/statistics \& numerical data, Humans, Infant, Malaria, Malaria Vaccines/administration \& dosage/adverse effects, Male, Mali/epidemiology, Pyrimethamine/therapeutic use, Seasons, Seizures, Sulfadoxine/therapeutic use},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria control remains a challenge in many parts of
the Sahel and sub-Sahel regions of Africa. METHODS: We conducted
an individually randomized, controlled trial to assess whether
seasonal vaccination with RTS,S/AS01E was noninferior to
chemoprevention in preventing uncomplicated malaria and whether
the two interventions combined were superior to either one alone
in preventing uncomplicated malaria and severe malaria-related
outcomes. RESULTS: We randomly assigned 6861 children 5 to 17
months of age to receive sulfadoxine-pyrimethamine and
amodiaquine (2287 children [chemoprevention-alone group]),
RTS,S/AS01E (2288 children [vaccine-alone group]), or
chemoprevention and RTS,S/AS01E (2286 children [combination
group]). Of these, 1965, 1988, and 1967 children in the three
groups, respectively, received the first dose of the assigned
intervention and were followed for 3 years. Febrile seizure
developed in 5 children the day after receipt of the vaccine,
but the children recovered and had no sequelae. There were 305
events of uncomplicated clinical malaria per 1000 person-years
at risk in the chemoprevention-alone group, 278 events per 1000
person-years in the vaccine-alone group, and 113 events per 1000
person-years in the combination group. The hazard ratio for the
protective efficacy of RTS,S/AS01E as compared with
chemoprevention was 0.92 (95% confidence interval [CI], 0.84 to
1.01), which excluded the prespecified noninferiority margin of
1.20. The protective efficacy of the combination as compared
with chemoprevention alone was 62.8% (95% CI, 58.4 to 66.8)
against clinical malaria, 70.5% (95% CI, 41.9 to 85.0) against
hospital admission with severe malaria according to the World
Health Organization definition, and 72.9% (95% CI, 2.9 to
92.4) against death from malaria. The protective efficacy of the
combination as compared with the vaccine alone against these
outcomes was 59.6% (95% CI, 54.7 to 64.0), 70.6% (95% CI,
42.3 to 85.0), and 75.3% (95% CI, 12.5 to 93.0), respectively.
CONCLUSIONS: Administration of RTS,S/AS01E was noninferior to
chemoprevention in preventing uncomplicated malaria. The
combination of these interventions resulted in a substantially
lower incidence of uncomplicated malaria, severe malaria, and
death from malaria than either intervention alone. (Funded by
the Joint Global Health Trials and PATH; ClinicalTrials.gov
number, NCT03143218.). |
| Isidore Tiandiogo Traoré, Samiratou Ouedraogo, Dramane Kania, Firmin Nongodo Kaboré, Blahima Konaté, Rachel Médah, Hermann Badolo, Nathalie Rekeneire, Ariane Mamguem Kamga, Armel Poda, Arnaud Eric Diendere, Boukary Ouédraogo, Esperance Ouédraogo, Oumar Billa, Halidou Tinto, Tienhan Sandrine Dabakuyo-Yonli COVID-19 epidemiological, sociological and anthropological investigation: study protocol for a multidisciplinary mixed methods research in Burkina Faso (Journal Article) In: BMC Infect. Dis., vol. 21, no. 1, pp. 896, 2021, ISSN: 1471-2334, (© 2021. The Author(s).
PMID: 34479501
PMCID: PMC8414025). @article{Traore2021-vr,
title = {COVID-19 epidemiological, sociological and anthropological investigation: study protocol for a multidisciplinary mixed methods research in Burkina Faso},
author = {Isidore Tiandiogo Traor\'{e} and Samiratou Ouedraogo and Dramane Kania and Firmin Nongodo Kabor\'{e} and Blahima Konat\'{e} and Rachel M\'{e}dah and Hermann Badolo and Nathalie Rekeneire and Ariane Mamguem Kamga and Armel Poda and Arnaud Eric Diendere and Boukary Ou\'{e}draogo and Esperance Ou\'{e}draogo and Oumar Billa and Halidou Tinto and Tienhan Sandrine Dabakuyo-Yonli},
doi = {10.1186/s12879-021-06543-4},
issn = {1471-2334},
year = {2021},
date = {2021-09-03},
urldate = {2021-09-03},
journal = {BMC Infect. Dis.},
volume = {21},
number = {1},
pages = {896},
abstract = {BACKGROUND: The world has high hopes of vaccination against
COVID-19 to protect the population, boost economies and return to
normal life. Vaccination programmes are being rolled out in high
income countries, but the pandemic continues to progress in many
low-and middle-income countries (LMICs) despite implementation of
strict hygiene measures. We aim to present a comprehensive
research protocol that will generate epidemiological,
sociological and anthropological data about the COVID-19 epidemic
in Burkina Faso, a landlocked country in West Africa with scarce
resources. METHODS: We will perform a multidisciplinary research
using mixed methods in the two main cities in Burkina Faso
(Ouagadougou and Bobo-Dioulasso). Data will be collected in the
general population and in COVID-19 patients, caregivers and
health care professionals in reference care centers: (i) to
determine cumulative incidence of SARS-CoV-2 infection in the
Burkinabe population using blood samples collected from randomly
selected households according to the WHO-recommended protocol;
(ii) develop a score to predict severe complications of COVID-19
in persons infected with SARS-CoV-2 using retrospective and
prospective data; (iii) perform semi-structured interviews and
direct observation on site, to describe and analyze the
healthcare pathways and experiences of patients with COVID-19
attending reference care centers, and to identify the
perceptions, acceptability and application of preventive
strategies among the population. DISCUSSION: This study will
generate comprehensive data that will contribute to improving
COVID-19 response strategies in Burkina Faso. The lessons learned
from the management of this epidemic may serve as examples to the
country authorities to better design preventive strategies in the
case of future epidemics or pandemics. The protocol was approved
by the Ministry for Health (N° 2020-00952/MS/CAB/INSP/CM) and the
Health Research Ethics Committee in Burkina Faso (N° 2020-8-140).},
note = {© 2021. The Author(s).
PMID: 34479501
PMCID: PMC8414025},
keywords = {Burkina Faso/epidemiology, Clinical epidemiology, COVID-19, Humans, Predictive score, Prospective Studies, Retrospective Studies, SARS-Cov-2, Sero-epidemiology, Socio-anthropology},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: The world has high hopes of vaccination against
COVID-19 to protect the population, boost economies and return to
normal life. Vaccination programmes are being rolled out in high
income countries, but the pandemic continues to progress in many
low-and middle-income countries (LMICs) despite implementation of
strict hygiene measures. We aim to present a comprehensive
research protocol that will generate epidemiological,
sociological and anthropological data about the COVID-19 epidemic
in Burkina Faso, a landlocked country in West Africa with scarce
resources. METHODS: We will perform a multidisciplinary research
using mixed methods in the two main cities in Burkina Faso
(Ouagadougou and Bobo-Dioulasso). Data will be collected in the
general population and in COVID-19 patients, caregivers and
health care professionals in reference care centers: (i) to
determine cumulative incidence of SARS-CoV-2 infection in the
Burkinabe population using blood samples collected from randomly
selected households according to the WHO-recommended protocol;
(ii) develop a score to predict severe complications of COVID-19
in persons infected with SARS-CoV-2 using retrospective and
prospective data; (iii) perform semi-structured interviews and
direct observation on site, to describe and analyze the
healthcare pathways and experiences of patients with COVID-19
attending reference care centers, and to identify the
perceptions, acceptability and application of preventive
strategies among the population. DISCUSSION: This study will
generate comprehensive data that will contribute to improving
COVID-19 response strategies in Burkina Faso. The lessons learned
from the management of this epidemic may serve as examples to the
country authorities to better design preventive strategies in the
case of future epidemics or pandemics. The protocol was approved
by the Ministry for Health (N° 2020-00952/MS/CAB/INSP/CM) and the
Health Research Ethics Committee in Burkina Faso (N° 2020-8-140). |
| Stephen A Roberts, Loretta Brabin, Halidou Tinto, Sabine Gies, Salou Diallo, Bernard Brabin Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data (Journal Article) In: BMC Public Health, vol. 21, no. 1, pp. 1764, 2021, ISSN: 1471-2458, (© 2021. The Author(s).
PMID: 34579679
PMCID: PMC8477466). @article{Roberts2021-gg,
title = {Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data},
author = {Stephen A Roberts and Loretta Brabin and Halidou Tinto and Sabine Gies and Salou Diallo and Bernard Brabin},
doi = {10.1186/s12889-021-11819-0},
issn = {1471-2458},
year = {2021},
date = {2021-09-01},
urldate = {2021-09-01},
journal = {BMC Public Health},
volume = {21},
number = {1},
pages = {1764},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Adolescents are considered at high risk of developing iron deficiency. Studies in children indicate that the prevalence of iron deficiency increased with malaria transmission, suggesting malaria seasonally may drive iron deficiency. This paper examines monthly seasonal infection patterns of malaria, abnormal vaginal flora, chorioamnionitis, antibiotic and antimalarial prescriptions, in relation to changes in iron biomarkers and nutritional indices in adolescents living in a rural area of Burkina Faso, in order to assess the requirement for seasonal infection control and nutrition interventions. METHODS: Data collected between April 2011 and January 2014 were available for an observational seasonal analysis, comprising scheduled visits for 1949 non-pregnant adolescents (≤19 years), (315 of whom subsequently became pregnant), enrolled in a randomised trial of periconceptional iron supplementation. Data from trial arms were combined. Body Iron Stores (BIS) were calculated using an internal regression for ferritin to allow for inflammation. At recruitment 11% had low BIS (\< 0 mg/kg). Continuous outcomes were fitted to a mixed-effects linear model with month, age and pregnancy status as fixed effect covariates and woman as a random effect. Dichotomous infection outcomes were fitted with analogous logistic regression models. RESULTS: Seasonal variation in malaria parasitaemia prevalence ranged between 18 and 70% in non-pregnant adolescents (P \< 0.001), peaking at 81% in those who became pregnant. Seasonal variation occurred in antibiotic prescription rates (0.7-1.8 prescriptions/100 weekly visits, P \< 0.001) and chorioamnionitis prevalence (range 15-68%, P = 0.026). Mucosal vaginal lactoferrin concentration was lower at the end of the wet season (range 2-22 μg/ml, P \< 0.016), when chorioamnionitis was least frequent. BIS fluctuated annually by up to 53.2% per year around the mean BIS (5.1 mg/kg(2), range 4.1-6.8 mg/kg), with low BIS (\< 0 mg/kg) of 8.7% in the dry and 9.8% in the wet seasons (P = 0.36). Median serum transferrin receptor increased during the wet season (P \< 0.001). Higher hepcidin concentration in the wet season corresponded with rising malaria prevalence and use of prescriptions, but with no change in BIS. Mean Body Mass Index and Mid-Upper-Arm-Circumference values peaked mid-dry season (both P \< 0.001). CONCLUSIONS: Our analysis supports preventive treatment of malaria among adolescents 15-19 years to decrease their disease burden, especially asymptomatic malaria. As BIS were adequate in most adolescents despite seasonal malaria, a requirement for programmatic iron supplementation was not substantiated.},
note = {© 2021. The Author(s).
PMID: 34579679
PMCID: PMC8477466},
keywords = {Abnormal vaginal flora, Adolescents, Bacterial vaginosis, Body Mass Index, Burkina Faso/epidemiology, Child, Female, Humans, Iron, iron biomarkers, Malaria, Malaria/drug therapy/epidemiology, MUAC, Pregnancy, Seasons, Vagina},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Adolescents are considered at high risk of developing iron deficiency. Studies in children indicate that the prevalence of iron deficiency increased with malaria transmission, suggesting malaria seasonally may drive iron deficiency. This paper examines monthly seasonal infection patterns of malaria, abnormal vaginal flora, chorioamnionitis, antibiotic and antimalarial prescriptions, in relation to changes in iron biomarkers and nutritional indices in adolescents living in a rural area of Burkina Faso, in order to assess the requirement for seasonal infection control and nutrition interventions. METHODS: Data collected between April 2011 and January 2014 were available for an observational seasonal analysis, comprising scheduled visits for 1949 non-pregnant adolescents (≤19 years), (315 of whom subsequently became pregnant), enrolled in a randomised trial of periconceptional iron supplementation. Data from trial arms were combined. Body Iron Stores (BIS) were calculated using an internal regression for ferritin to allow for inflammation. At recruitment 11% had low BIS (< 0 mg/kg). Continuous outcomes were fitted to a mixed-effects linear model with month, age and pregnancy status as fixed effect covariates and woman as a random effect. Dichotomous infection outcomes were fitted with analogous logistic regression models. RESULTS: Seasonal variation in malaria parasitaemia prevalence ranged between 18 and 70% in non-pregnant adolescents (P < 0.001), peaking at 81% in those who became pregnant. Seasonal variation occurred in antibiotic prescription rates (0.7-1.8 prescriptions/100 weekly visits, P < 0.001) and chorioamnionitis prevalence (range 15-68%, P = 0.026). Mucosal vaginal lactoferrin concentration was lower at the end of the wet season (range 2-22 μg/ml, P < 0.016), when chorioamnionitis was least frequent. BIS fluctuated annually by up to 53.2% per year around the mean BIS (5.1 mg/kg(2), range 4.1-6.8 mg/kg), with low BIS (< 0 mg/kg) of 8.7% in the dry and 9.8% in the wet seasons (P = 0.36). Median serum transferrin receptor increased during the wet season (P < 0.001). Higher hepcidin concentration in the wet season corresponded with rising malaria prevalence and use of prescriptions, but with no change in BIS. Mean Body Mass Index and Mid-Upper-Arm-Circumference values peaked mid-dry season (both P < 0.001). CONCLUSIONS: Our analysis supports preventive treatment of malaria among adolescents 15-19 years to decrease their disease burden, especially asymptomatic malaria. As BIS were adequate in most adolescents despite seasonal malaria, a requirement for programmatic iron supplementation was not substantiated. |
| Navideh Noori, Karim Derra, Innocent Valea, Assaf P Oron, Aminata Welgo, Toussaint Rouamba, Palwende Romuald Boua, Athanase M Somé, Eli Rouamba, Edward Wenger, Hermann Sorgho, Halidou Tinto, Andre Lin Ouédraogo Patterns of child mortality in rural area of Burkina Faso: evidence from the Nanoro health and demographic surveillance system (HDSS) (Journal Article) In: BMC Public Health, vol. 21, no. 1, pp. 1425, 2021, ISSN: 1471-2458, (© 2021. The Author(s).
PMID: 34281547
PMCID: PMC8287796). @article{Noori2021-te,
title = {Patterns of child mortality in rural area of Burkina Faso: evidence from the Nanoro health and demographic surveillance system (HDSS)},
author = {Navideh Noori and Karim Derra and Innocent Valea and Assaf P Oron and Aminata Welgo and Toussaint Rouamba and Palwende Romuald Boua and Athanase M Som\'{e} and Eli Rouamba and Edward Wenger and Hermann Sorgho and Halidou Tinto and Andre Lin Ou\'{e}draogo},
doi = {10.1186/s12889-021-11483-4},
issn = {1471-2458},
year = {2021},
date = {2021-07-19},
urldate = {2021-07-19},
journal = {BMC Public Health},
volume = {21},
number = {1},
pages = {1425},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Half of global child deaths occur in sub-Saharan
Africa. Understanding child mortality patterns and risk factors
will help inform interventions to reduce this heavy toll. The
Nanoro Health and Demographic Surveillance System (HDSS),
Burkina Faso was described previously, but patterns and
potential drivers of heterogeneity in child mortality in the
district had not been studied. Similar studies in other
districts indicated proximity to health facilities as a risk
factor, usually without distinction between facility types.
METHODS: Using Nanoro HDSS data from 2009 to 2013, we estimated
the association between under-5 mortality and proximity to
inpatient and outpatient health facilities, seasonality of
death, age group, and standard demographic risk factors.
RESULTS: Living in homes 40-60 min and \> 60 min travel time from
an inpatient facility was associated with 1.52 (95% CI:
1.13-2.06) and 1.74 (95% CI: 1.27-2.40) greater hazard of
under-5 mortality, respectively, than living in homes \< 20 min
from an inpatient facility. No such association was found for
outpatient facilities. The wet season (July-November) was
associated with 1.28 (95% CI: 1.07, 1.53) higher under-5
mortality than the dry season (December-June), likely reflecting
the malaria season. CONCLUSIONS: Our results emphasize the
importance of geographical proximity to health care, distinguish
between inpatient and outpatient facilities, and also show a
seasonal effect, probably driven by malaria.},
note = {© 2021. The Author(s).
PMID: 34281547
PMCID: PMC8287796},
keywords = {Burkina Faso, Burkina Faso/epidemiology, child mortality, ChildHealth Facilities, Children under 5, Demographic surveillance, HDSS, Humans, Infant, Malaria, Nanoro, Spatial analysis, Travel},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Half of global child deaths occur in sub-Saharan
Africa. Understanding child mortality patterns and risk factors
will help inform interventions to reduce this heavy toll. The
Nanoro Health and Demographic Surveillance System (HDSS),
Burkina Faso was described previously, but patterns and
potential drivers of heterogeneity in child mortality in the
district had not been studied. Similar studies in other
districts indicated proximity to health facilities as a risk
factor, usually without distinction between facility types.
METHODS: Using Nanoro HDSS data from 2009 to 2013, we estimated
the association between under-5 mortality and proximity to
inpatient and outpatient health facilities, seasonality of
death, age group, and standard demographic risk factors.
RESULTS: Living in homes 40-60 min and > 60 min travel time from
an inpatient facility was associated with 1.52 (95% CI:
1.13-2.06) and 1.74 (95% CI: 1.27-2.40) greater hazard of
under-5 mortality, respectively, than living in homes < 20 min
from an inpatient facility. No such association was found for
outpatient facilities. The wet season (July-November) was
associated with 1.28 (95% CI: 1.07, 1.53) higher under-5
mortality than the dry season (December-June), likely reflecting
the malaria season. CONCLUSIONS: Our results emphasize the
importance of geographical proximity to health care, distinguish
between inpatient and outpatient facilities, and also show a
seasonal effect, probably driven by malaria. |
| Marie Jaspard, Mamadou Saliou Sow, Sylvain Juchet, Eric Dienderé, Beatrice Serra, Richard Kojan, Billy Sivahera, Caroline Martin, Moumouni Kinda, Hans-Joerg Lang, Fodé Bangaly Sako, Fodé Amara Traoré, Eudoxie Koumbem, Halidou Tinto, Adama Sanou, Apoline Sondo, Flavien Kaboré, Joseph Donamou, Jean-Paul-Yassa Guilavogui, Fanny Velardo, Brice Bicaba, Olivier Marcy, Augustin Augier, Sani Sayadi, Armel Poda, Sakoba Keita, Xavier Anglaret, Denis Malvy, COVISTA group Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa (Journal Article) In: Int. J. Infect. Dis., vol. 108, pp. 45–52, 2021, ISSN: 1878-3511 1201-9712, (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
PMID: 34000419
PMCID: PMC8120805). @article{Jaspard2021-bl,
title = {Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa},
author = {Marie Jaspard and Mamadou Saliou Sow and Sylvain Juchet and Eric Diender\'{e} and Beatrice Serra and Richard Kojan and Billy Sivahera and Caroline Martin and Moumouni Kinda and Hans-Joerg Lang and Fod\'{e} Bangaly Sako and Fod\'{e} Amara Traor\'{e} and Eudoxie Koumbem and Halidou Tinto and Adama Sanou and Apoline Sondo and Flavien Kabor\'{e} and Joseph Donamou and Jean-Paul-Yassa Guilavogui and Fanny Velardo and Brice Bicaba and Olivier Marcy and Augustin Augier and Sani Sayadi and Armel Poda and Sakoba Keita and Xavier Anglaret and Denis Malvy and COVISTA group},
doi = {10.1016/j.ijid.2021.05.024},
issn = {1878-3511 1201-9712},
year = {2021},
date = {2021-07-01},
urldate = {2021-07-01},
journal = {Int. J. Infect. Dis.},
volume = {108},
pages = {45--52},
publisher = {Elsevier BV},
abstract = {OBJECTIVES: The overall death toll from COVID-19 in Africa is
reported to be low but there is little individual-level evidence
on the severity of the disease. This study examined the clinical
spectrum and outcome of patients monitored in COVID-19 care
centres (CCCs) in two West-African countries. METHODS: Burkina
Faso and Guinea set up referral CCCs to hospitalise all
symptomatic SARS-CoV-2 carriers, regardless of the severity of
their symptoms. Data collected from hospitalised patients by
November 2020 are presented. RESULT: A total of 1,805 patients
(64% men, median age 41 years) were admitted with COVID-19.
Symptoms lasted for a median of 7 days (IQR 4-11). During
hospitalisation, 443 (25%) had a SpO2 \< 94% at least once, 237
(13%) received oxygen and 266 (15%) took corticosteroids.
Mortality was 5% overall, and 1%, 5% and 14% in patients
aged \<40, 40-59 and $geq$60 years, respectively. In
multivariable analysis, the risk of death was higher in men (aOR
2.0, 95% CI 1.1; 3.6), people aged $geq$60 years (aOR 2.9,
95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1,
95% CI 1.2; 3.4). CONCLUSION: COVID-19 is as severe in Africa
as elsewhere, and there must be more vigilance for common risk
factors such as older age and hypertension.},
note = {Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
PMID: 34000419
PMCID: PMC8120805},
keywords = {Adult, Aged, Burkina Faso/epidemiology, Comorbidities, COVID-19, Female, Hospitalization, Humans, Male, Mortality, Prospective Studies, Referral and Consultation, SARS-Cov-2, sub-Saharan Africa},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: The overall death toll from COVID-19 in Africa is
reported to be low but there is little individual-level evidence
on the severity of the disease. This study examined the clinical
spectrum and outcome of patients monitored in COVID-19 care
centres (CCCs) in two West-African countries. METHODS: Burkina
Faso and Guinea set up referral CCCs to hospitalise all
symptomatic SARS-CoV-2 carriers, regardless of the severity of
their symptoms. Data collected from hospitalised patients by
November 2020 are presented. RESULT: A total of 1,805 patients
(64% men, median age 41 years) were admitted with COVID-19.
Symptoms lasted for a median of 7 days (IQR 4-11). During
hospitalisation, 443 (25%) had a SpO2 < 94% at least once, 237
(13%) received oxygen and 266 (15%) took corticosteroids.
Mortality was 5% overall, and 1%, 5% and 14% in patients
aged <40, 40-59 and $geq$60 years, respectively. In
multivariable analysis, the risk of death was higher in men (aOR
2.0, 95% CI 1.1; 3.6), people aged $geq$60 years (aOR 2.9,
95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1,
95% CI 1.2; 3.4). CONCLUSION: COVID-19 is as severe in Africa
as elsewhere, and there must be more vigilance for common risk
factors such as older age and hypertension. |
| Mariken Wit, Matthew Cairns, Yves Daniel Compaoré, Issaka Sagara, Irene Kuepfer, Issaka Zongo, Amadou Barry, Modibo Diarra, Amadou Tapily, Samba Coumare, Ismaila Thera, Frederic Nikiema, R Serge Yerbanga, Rosemonde M Guissou, Halidou Tinto, Alassane Dicko, Daniel Chandramohan, Brian Greenwood, Jean Bosco Ouedraogo Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria (Journal Article) In: Malar. J., vol. 20, no. 1, pp. 274, 2021, ISSN: 1475-2875, (PMID: 34158054
PMCID: PMC8220741). @article{De_Wit2021-yi,
title = {Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria},
author = {Mariken Wit and Matthew Cairns and Yves Daniel Compaor\'{e} and Issaka Sagara and Irene Kuepfer and Issaka Zongo and Amadou Barry and Modibo Diarra and Amadou Tapily and Samba Coumare and Ismaila Thera and Frederic Nikiema and R Serge Yerbanga and Rosemonde M Guissou and Halidou Tinto and Alassane Dicko and Daniel Chandramohan and Brian Greenwood and Jean Bosco Ouedraogo},
doi = {10.1186/s12936-021-03802-2},
issn = {1475-2875},
year = {2021},
date = {2021-06-22},
urldate = {2021-06-22},
journal = {Malar. J.},
volume = {20},
number = {1},
pages = {274},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Malaria and malnutrition remain major problems in
Sahel countries, especially in young children. The direct effect
of malnutrition on malaria remains poorly understood, and may
have important implications for malaria control. In this study,
nutritional status and the association between malnutrition and
subsequent incidence of symptomatic malaria were examined in
children in Burkina Faso and Mali who received either
azithromycin or placebo, alongside seasonal malaria
chemoprevention. METHODS: Mid-upper arm circumference (MUAC) was
measured in all 20,185 children who attended a screening visit
prior to the malaria transmission season in 2015. Prior to the
2016 malaria season, weight, height and MUAC were measured among
4149 randomly selected children. Height-for-age, weight-for-age,
weight-for-height, and MUAC-for-age were calculated as
indicators of nutritional status. Malaria incidence was measured
during the following rainy seasons. Multivariable random effects
Poisson models were created for each nutritional indicator to
study the effect of malnutrition on clinical malaria incidence
for each country. RESULTS: In both 2015 and 2016, nutritional
status prior to the malaria season was poor. The most prevalent
form of malnutrition in Burkina Faso was being underweight
(30.5%; 95% CI 28.6-32.6), whereas in Mali stunting was most
prevalent (27.5%; 95% CI 25.6-29.5). In 2016, clinical malaria
incidence was 675 per 1000 person-years (95% CI 613-744) in
Burkina Faso, and 1245 per 1000 person-years (95% CI 1152-1347)
in Mali. There was some evidence that severe stunting was
associated with lower incidence of malaria in Mali (RR 0.81; 95% CI 0.64-1.02; p = 0.08), but this association was not seen
in Burkina Faso. Being moderately underweight tended to be
associated with higher incidence of clinical malaria in Burkina Faso (RR 1.27; 95% CI 0.98-1.64; p = 0.07), while this was the
case in Mali for moderate wasting (RR 1.27; 95% CI 0.98-1.64; p = 0.07). However, these associations were not observed in
severely affected children, nor consistent between countries.
MUAC-for-age was not associated with malaria risk. CONCLUSIONS:
Both malnutrition and malaria were common in the study areas,
high despite high coverage of seasonal malaria chemoprevention
and long-lasting insecticidal nets. However, no strong or
consistent evidence was found for an association between any of
the nutritional indicators and the subsequent incidence of
clinical malaria.},
note = {PMID: 34158054
PMCID: PMC8220741},
keywords = {Acute malnutrition, Antimalarials/administration \& dosage, Azithromycin/administration \& dosage, Burkina Faso, Burkina Faso/epidemiology, Child, Chronic malnutrition, Female, Humans, Incidence, Infant, Malaria, Malaria/epidemiology/transmission, Male, Nutritional Status, Preschool, seasonal malaria chemoprevention, Seasons},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria and malnutrition remain major problems in
Sahel countries, especially in young children. The direct effect
of malnutrition on malaria remains poorly understood, and may
have important implications for malaria control. In this study,
nutritional status and the association between malnutrition and
subsequent incidence of symptomatic malaria were examined in
children in Burkina Faso and Mali who received either
azithromycin or placebo, alongside seasonal malaria
chemoprevention. METHODS: Mid-upper arm circumference (MUAC) was
measured in all 20,185 children who attended a screening visit
prior to the malaria transmission season in 2015. Prior to the
2016 malaria season, weight, height and MUAC were measured among
4149 randomly selected children. Height-for-age, weight-for-age,
weight-for-height, and MUAC-for-age were calculated as
indicators of nutritional status. Malaria incidence was measured
during the following rainy seasons. Multivariable random effects
Poisson models were created for each nutritional indicator to
study the effect of malnutrition on clinical malaria incidence
for each country. RESULTS: In both 2015 and 2016, nutritional
status prior to the malaria season was poor. The most prevalent
form of malnutrition in Burkina Faso was being underweight
(30.5%; 95% CI 28.6-32.6), whereas in Mali stunting was most
prevalent (27.5%; 95% CI 25.6-29.5). In 2016, clinical malaria
incidence was 675 per 1000 person-years (95% CI 613-744) in
Burkina Faso, and 1245 per 1000 person-years (95% CI 1152-1347)
in Mali. There was some evidence that severe stunting was
associated with lower incidence of malaria in Mali (RR 0.81; 95% CI 0.64-1.02; p = 0.08), but this association was not seen
in Burkina Faso. Being moderately underweight tended to be
associated with higher incidence of clinical malaria in Burkina Faso (RR 1.27; 95% CI 0.98-1.64; p = 0.07), while this was the
case in Mali for moderate wasting (RR 1.27; 95% CI 0.98-1.64; p = 0.07). However, these associations were not observed in
severely affected children, nor consistent between countries.
MUAC-for-age was not associated with malaria risk. CONCLUSIONS:
Both malnutrition and malaria were common in the study areas,
high despite high coverage of seasonal malaria chemoprevention
and long-lasting insecticidal nets. However, no strong or
consistent evidence was found for an association between any of
the nutritional indicators and the subsequent incidence of
clinical malaria. |
| Annelies Post, Berenger Kaboré, Mike Berendsen, Salou Diallo, Ousmane Traore, Rob J W Arts, Mihai G Netea, Leo A B Joosten, Halidou Tinto, Jan Jacobs, Quirijn Mast, André Ven Altered ex-vivo cytokine responses in children with asymptomatic Plasmodium falciparum infection in Burkina Faso: An additional argument to treat asymptomatic malaria? (Journal Article) In: Front. Immunol., vol. 12, pp. 614817, 2021, ISSN: 1664-3224, (Copyright © 2021 Post, Kaboré, Berendsen, Diallo, Traore, Arts, Netea, Joosten, Tinto, Jacobs, de Mast and van der Ven.
PMID: 34177883
PMCID: PMC8220162). @article{Post2021-oo,
title = {Altered ex-vivo cytokine responses in children with asymptomatic Plasmodium falciparum infection in Burkina Faso: An additional argument to treat asymptomatic malaria?},
author = {Annelies Post and Berenger Kabor\'{e} and Mike Berendsen and Salou Diallo and Ousmane Traore and Rob J W Arts and Mihai G Netea and Leo A B Joosten and Halidou Tinto and Jan Jacobs and Quirijn Mast and Andr\'{e} Ven},
doi = {10.3389/fimmu.2021.614817},
issn = {1664-3224},
year = {2021},
date = {2021-06-09},
urldate = {2021-06-09},
journal = {Front. Immunol.},
volume = {12},
pages = {614817},
publisher = {Frontiers Media SA},
abstract = {Introduction: Patients with clinical malaria have an increased
risk for bacterial bloodstream infections. We hypothesized that
asymptomatic malaria parasitemia increases susceptibility for
bacterial infections through an effect on the innate immune
system. We measured circulating cytokine levels and ex-vivo
cytokine production capacity in asymptomatic malaria and
compared with controls. Methods: Data were collected from
asymptomatic participants \<5 years old with and without positive
malaria microscopy, as well as from hospitalized patients \<5
years old with clinical malaria, bacteremia, or
malaria/bacteremia co-infections in a malaria endemic region of
Burkina Faso. Circulating cytokines (TNF-$alpha$, IFN-$gamma$,
IL-6, IL-10) were measured using multiplex assays. Whole blood
from asymptomatic participants with and without positive malaria
microscopy were ex-vivo stimulated with S. aureus, E. coli LPS
and Salmonella Typhimurium; cytokine concentrations
(TNF-$alpha$, IFN-$gamma$, IL-1$beta$, IL-6, IL-10) were
measured on supernatants using ELISA. Results: Included were children with clinical malaria (n=118), bacteremia (n=22), malaria and bacteremia co-infection (n=9), asymptomatic malaria (n=125), and asymptomatic controls (n=237). Children with either
clinical or asymptomatic malaria had higher plasma cytokine
concentrations than controls. Cytokine concentrations correlated
positively with malaria parasite density with the strongest correlation for IL-10 in both asymptomatic (r=0.63) and clinical malaria (r=0.53). Patients with bacteremia had lower circulating
IL-10, TNF-$alpha$ and IFN-$gamma$ and higher IL-6
concentrations, compared to clinical malaria. Ex-vivo whole
blood cytokine production to LPS and S. aureus was significantly
lower in asymptomatic malaria compared to controls. Whole blood
IFN-$gamma$ and IL-10 production in response to Salmonella was
also lower in asymptomatic malaria. Interpretation: In children
with asymptomatic malaria, cytokine responses upon ex-vivo
bacterial stimulation are downregulated. Further studies are
needed to explore if the suggested impaired innate immune
response to bacterial pathogens also translates into impaired
control of pathogens such as Salmonella spp.},
note = {Copyright © 2021 Post, Kabor\'{e}, Berendsen, Diallo, Traore, Arts, Netea, Joosten, Tinto, Jacobs, de Mast and van der Ven.
PMID: 34177883
PMCID: PMC8220162},
keywords = {Asymptomatic Diseases, asymptomatic malaria, bacteraemia, Bacteremia, bloodstream infection, Burkina Faso/epidemiology, Cells, Child, Cultured, Cytokines/metabolism, Endemic Diseases, Female, Humans, Infant, iNTS, Lipopolysaccharides/immunology, Malaria/epidemiology/immunology, Male, Parasite Load, Plasmodium falciparum/physiology, Preschool, Salmonella},
pubstate = {published},
tppubtype = {article}
}
Introduction: Patients with clinical malaria have an increased
risk for bacterial bloodstream infections. We hypothesized that
asymptomatic malaria parasitemia increases susceptibility for
bacterial infections through an effect on the innate immune
system. We measured circulating cytokine levels and ex-vivo
cytokine production capacity in asymptomatic malaria and
compared with controls. Methods: Data were collected from
asymptomatic participants <5 years old with and without positive
malaria microscopy, as well as from hospitalized patients <5
years old with clinical malaria, bacteremia, or
malaria/bacteremia co-infections in a malaria endemic region of
Burkina Faso. Circulating cytokines (TNF-$alpha$, IFN-$gamma$,
IL-6, IL-10) were measured using multiplex assays. Whole blood
from asymptomatic participants with and without positive malaria
microscopy were ex-vivo stimulated with S. aureus, E. coli LPS
and Salmonella Typhimurium; cytokine concentrations
(TNF-$alpha$, IFN-$gamma$, IL-1$beta$, IL-6, IL-10) were
measured on supernatants using ELISA. Results: Included were children with clinical malaria (n=118), bacteremia (n=22), malaria and bacteremia co-infection (n=9), asymptomatic malaria (n=125), and asymptomatic controls (n=237). Children with either
clinical or asymptomatic malaria had higher plasma cytokine
concentrations than controls. Cytokine concentrations correlated
positively with malaria parasite density with the strongest correlation for IL-10 in both asymptomatic (r=0.63) and clinical malaria (r=0.53). Patients with bacteremia had lower circulating
IL-10, TNF-$alpha$ and IFN-$gamma$ and higher IL-6
concentrations, compared to clinical malaria. Ex-vivo whole
blood cytokine production to LPS and S. aureus was significantly
lower in asymptomatic malaria compared to controls. Whole blood
IFN-$gamma$ and IL-10 production in response to Salmonella was
also lower in asymptomatic malaria. Interpretation: In children
with asymptomatic malaria, cytokine responses upon ex-vivo
bacterial stimulation are downregulated. Further studies are
needed to explore if the suggested impaired innate immune
response to bacterial pathogens also translates into impaired
control of pathogens such as Salmonella spp. |
| Paul Sondo, Marc Christian Tahita, Toussaint Rouamba, Karim Derra, Bérenger Kaboré, Cheick Sa"id Compaoré, Florence Ouédraogo, Eli Rouamba, Hamidou Ilboudo, Estelle A"issa Bambara, Macaire Nana, Edmond Yabré Sawadogo, Hermann Sorgho, Athanase Mwinessobaonfou Somé, Innocent Valéa, Prabin Dahal, Maminata Traoré/Coulibaly, Halidou Tinto Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy’Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT) (Journal Article) In: Trials, vol. 22, no. 1, pp. 360, 2021, ISSN: 1745-6215, (PMID: 34030705
PMCID: PMC8142067). @article{Sondo2021-kc,
title = {Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy'Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT)},
author = {Paul Sondo and Marc Christian Tahita and Toussaint Rouamba and Karim Derra and B\'{e}renger Kabor\'{e} and Cheick Sa"id Compaor\'{e} and Florence Ou\'{e}draogo and Eli Rouamba and Hamidou Ilboudo and Estelle A"issa Bambara and Macaire Nana and Edmond Yabr\'{e} Sawadogo and Hermann Sorgho and Athanase Mwinessobaonfou Som\'{e} and Innocent Val\'{e}a and Prabin Dahal and Maminata Traor\'{e}/Coulibaly and Halidou Tinto},
doi = {10.1186/s13063-021-05320-7},
issn = {1745-6215},
year = {2021},
date = {2021-05-24},
urldate = {2021-05-24},
journal = {Trials},
volume = {22},
number = {1},
pages = {360},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Malaria and malnutrition represent major public
health concerns worldwide especially in Sub-Sahara Africa.
Despite implementation of seasonal malaria chemoprophylaxis
(SMC), an intervention aimed at reducing malaria incidence among
children aged 3-59 months, the burden of malaria and associated
mortality among children below age 5 years remains high in
Burkina Faso. Malnutrition, in particular micronutrient
deficiency, appears to be one of the potential factors that can
negatively affect the effectiveness of SMC. Treating
micronutrient deficiencies is known to reduce the incidence of
malaria in highly prevalent malaria zone such as rural settings.
Therefore, we hypothesized that a combined strategy of SMC
together with a daily oral nutrients supplement will enhance the
immune response and decrease the incidence of malaria and
malnutrition among children under SMC coverage. METHODS:
Children (6-59 months) under SMC coverage receiving vitamin A
supplementation will be randomly assigned to one of the three
study arms (a) SMC + vitamin A alone, (b) SMC + vitamin A +
zinc, or (c) SMC + vitamin A + Plumpy'Doz™ using 1:1:1
allocation ratio. After each SMC monthly distribution, children
will be visited at home to confirm drug administration and
followed-up for 1 year. Anthropometric indicators will be
recorded at each visit and blood samples will be collected for
microscopy slides, haemoglobin measurement, and spotted onto
filter paper for further PCR analyses. The primary outcome
measure is the incidence of malaria in each arm. Secondary
outcome measures will include mid-upper arm circumference and
weight gain from baseline measurements, coverage and compliance
to SMC, occurrence of adverse events (AEs), and prevalence of
molecular markers of antimalarial resistance comprising Pfcrt,
Pfmdr1, Pfdhfr, and Pfdhps. DISCUSSION: This study will
demonstrate an integrated strategy of malaria and malnutrition
programmes in order to mutualize resources for best impact. By
relying on existing strategies, the policy implementation of
this joint intervention will be scalable at country and regional
levels. TRIAL REGISTRATION: ClinicalTrials.gov NCT04238845 .
Registered on 23 January 2020
https://clinicaltrials.gov/ct2/show/NCT04238845.},
note = {PMID: 34030705
PMCID: PMC8142067},
keywords = {Antimalarials/adverse effects, Burkina Faso/epidemiology, Chemoprevention, Child, Child Nutrition Disorders, Dietary Supplements, Humans, Infant, Malaria, Malaria/diagnosis/epidemiology/prevention \& control, Malnutrition, Malnutrition/diagnosis/drug therapy/prevention \& control, Pharmaceutical Preparations, Plumpy’Doz™, Preschool, Randomized controlled trial, Seasonal chemoprevention, Seasons, Vitamin A, Vitamin A/adverse effects, Zinc},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria and malnutrition represent major public
health concerns worldwide especially in Sub-Sahara Africa.
Despite implementation of seasonal malaria chemoprophylaxis
(SMC), an intervention aimed at reducing malaria incidence among
children aged 3-59 months, the burden of malaria and associated
mortality among children below age 5 years remains high in
Burkina Faso. Malnutrition, in particular micronutrient
deficiency, appears to be one of the potential factors that can
negatively affect the effectiveness of SMC. Treating
micronutrient deficiencies is known to reduce the incidence of
malaria in highly prevalent malaria zone such as rural settings.
Therefore, we hypothesized that a combined strategy of SMC
together with a daily oral nutrients supplement will enhance the
immune response and decrease the incidence of malaria and
malnutrition among children under SMC coverage. METHODS:
Children (6-59 months) under SMC coverage receiving vitamin A
supplementation will be randomly assigned to one of the three
study arms (a) SMC + vitamin A alone, (b) SMC + vitamin A +
zinc, or (c) SMC + vitamin A + Plumpy’Doz™ using 1:1:1
allocation ratio. After each SMC monthly distribution, children
will be visited at home to confirm drug administration and
followed-up for 1 year. Anthropometric indicators will be
recorded at each visit and blood samples will be collected for
microscopy slides, haemoglobin measurement, and spotted onto
filter paper for further PCR analyses. The primary outcome
measure is the incidence of malaria in each arm. Secondary
outcome measures will include mid-upper arm circumference and
weight gain from baseline measurements, coverage and compliance
to SMC, occurrence of adverse events (AEs), and prevalence of
molecular markers of antimalarial resistance comprising Pfcrt,
Pfmdr1, Pfdhfr, and Pfdhps. DISCUSSION: This study will
demonstrate an integrated strategy of malaria and malnutrition
programmes in order to mutualize resources for best impact. By
relying on existing strategies, the policy implementation of
this joint intervention will be scalable at country and regional
levels. TRIAL REGISTRATION: ClinicalTrials.gov NCT04238845 .
Registered on 23 January 2020
https://clinicaltrials.gov/ct2/show/NCT04238845. |
| Toussaint Rouamba, Sékou Samadoulougou, Mady Ouédraogo, Hervé Hien, Halidou Tinto, Fati Kirakoya-Samadoulougou Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017 (Journal Article) In: Malar. J., vol. 20, no. 1, pp. 211, 2021, ISSN: 1475-2875. @article{Rouamba2021-gn,
title = {Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017},
author = {Toussaint Rouamba and S\'{e}kou Samadoulougou and Mady Ou\'{e}draogo and Herv\'{e} Hien and Halidou Tinto and Fati Kirakoya-Samadoulougou},
doi = {10.1186/s12936-021-03703-4},
issn = {1475-2875},
year = {2021},
date = {2021-05-01},
urldate = {2021-05-01},
journal = {Malar. J.},
volume = {20},
number = {1},
pages = {211},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Malaria in endemic countries is often asymptomatic
during pregnancy, but it has substantial consequences for both
the mother and her unborn baby. During pregnancy, anaemia is an
important consequence of malaria infection. In Burkina Faso, the
intensity of malaria varies according to the season, albeit the
prevalence of malaria and anaemia as well as their risk factors,
during high and low malaria transmission seasons is
underexplored at the household level. METHODS: Data of 1751
pregnant women from October 2013 to March 2014 and 1931 pregnant
women from April 2017 to June 2017 were drawn from two
cross-sectional household surveys conducted in 24 health
districts of Burkina Faso. Pregnant women were tested for
malaria in their household after consenting. Asymptomatic
carriage was defined as a positive result from malaria rapid
diagnostic tests in the absence of clinical symptoms of malaria.
Anaemia was defined as haemoglobin level less than 11 g/dL in
the first and third trimester and less than 10.5 g/dL in the
second trimester of pregnancy. RESULTS: Prevalence of
asymptomatic malaria in pregnancy was estimated at 23.9% (95%
CI 20.2-28.0) during the high transmission season
(October-November) in 2013. During the low transmission season,
it was 12.7% (95% CI 10.9-14.7) between December and March in
2013-2014 and halved (6.4%; 95% CI 5.3-7.6) between April and
June 2017. Anaemia prevalence was estimated at 59.4% (95% CI
54.8-63.8) during the high transmission season in 2013. During
the low transmission season, it was 50.6% (95% CI 47.7-53.4)
between December and March 2013-2014 and 65.0% (95% CI
62.8-67.2) between April and June, 2017. CONCLUSION: This study
revealed that the prevalence of malaria asymptomatic carriage
and anaemia among pregnant women at the community level remain
high throughout the year. Thus, more efforts are needed to
increase prevention measures such as IPTp-SP coverage in order
to reduce anaemia and contribute to preventing low birth weight
and poor pregnancy outcomes.},
keywords = {Adult, Anemia/epidemiology/parasitology, Asymptomatic carriage, Asymptomatic Infections/epidemiology, Burkina Faso/epidemiology, Community, Cross-Sectional Studies, Female, Haemoglobin, Humans, Malaria/epidemiology/parasitology, Parasitic/epidemiology/parasitology, Plasmodium, Pregnancy, Pregnancy Complications, Pregnant, Pregnant Women, Prevalence, Young Adult},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Malaria in endemic countries is often asymptomatic
during pregnancy, but it has substantial consequences for both
the mother and her unborn baby. During pregnancy, anaemia is an
important consequence of malaria infection. In Burkina Faso, the
intensity of malaria varies according to the season, albeit the
prevalence of malaria and anaemia as well as their risk factors,
during high and low malaria transmission seasons is
underexplored at the household level. METHODS: Data of 1751
pregnant women from October 2013 to March 2014 and 1931 pregnant
women from April 2017 to June 2017 were drawn from two
cross-sectional household surveys conducted in 24 health
districts of Burkina Faso. Pregnant women were tested for
malaria in their household after consenting. Asymptomatic
carriage was defined as a positive result from malaria rapid
diagnostic tests in the absence of clinical symptoms of malaria.
Anaemia was defined as haemoglobin level less than 11 g/dL in
the first and third trimester and less than 10.5 g/dL in the
second trimester of pregnancy. RESULTS: Prevalence of
asymptomatic malaria in pregnancy was estimated at 23.9% (95%
CI 20.2-28.0) during the high transmission season
(October-November) in 2013. During the low transmission season,
it was 12.7% (95% CI 10.9-14.7) between December and March in
2013-2014 and halved (6.4%; 95% CI 5.3-7.6) between April and
June 2017. Anaemia prevalence was estimated at 59.4% (95% CI
54.8-63.8) during the high transmission season in 2013. During
the low transmission season, it was 50.6% (95% CI 47.7-53.4)
between December and March 2013-2014 and 65.0% (95% CI
62.8-67.2) between April and June, 2017. CONCLUSION: This study
revealed that the prevalence of malaria asymptomatic carriage
and anaemia among pregnant women at the community level remain
high throughout the year. Thus, more efforts are needed to
increase prevention measures such as IPTp-SP coverage in order
to reduce anaemia and contribute to preventing low birth weight
and poor pregnancy outcomes. |
| Palpouguini Lompo, Marc Christian Tahita, Hermann Sorgho, William Kaboré, Adama Kazienga, Ashmed Cheick Bachirou Nana, Hamtandi Magloire Natama, Isidore Juste Ouindgueta Bonkoungou, Nicolas Barro, Halidou Tinto Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso (Journal Article) In: Pan Afr. Med. J., vol. 38, pp. 259, 2021, ISSN: 1937-8688, (Copyright: Palpouguini Lompo et al.
PMID: 34104307
PMCID: PMC8164431). @article{Lompo2021-sk,
title = {Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso},
author = {Palpouguini Lompo and Marc Christian Tahita and Hermann Sorgho and William Kabor\'{e} and Adama Kazienga and Ashmed Cheick Bachirou Nana and Hamtandi Magloire Natama and Isidore Juste Ouindgueta Bonkoungou and Nicolas Barro and Halidou Tinto},
doi = {10.11604/pamj.2021.38.259.15864},
issn = {1937-8688},
year = {2021},
date = {2021-03-01},
urldate = {2021-03-01},
journal = {Pan Afr. Med. J.},
volume = {38},
pages = {259},
publisher = {Pan African Medical Journal},
abstract = {INTRODUCTION: acute diarrhea in children under five years is a public health problem in developing countries and particularly in malaria-endemic areas where both diseases co-exist. The present study examined the etiology of childhood diarrhea and its comorbidity with malaria in a rural area of Burkina Faso.
METHODS: conventional culture techniques, direct stools examination, and viruses´ detection by rapid tests were performed on the fresh stools and microscopy was used to diagnose malaria. Some risk factors were also assessed. RESULTS: on a total of 191 samples collected, at least one pathogen was identified in 89 cases (46.6%). The proportions of pathogens found on the 89 positive stool samples were parasites 51.69% (46 cases), viruses 39.33% (35 cases), and bacteria 14.61% (13 cases), respectively. The relationship between malaria and infectious diarrhea was significant in viral and parasites causes (p=0.005 and 0.043 respectively). Fever, vomiting and abdominal pain were the major symptoms associated with diarrhea, with 71.51%, 31.72% and 23.66% respectively. The highest viral diarrhea prevalence was reported during the dry season (OR=5.29, 95% CI: 1.74 - 16.07, p=0.001) while parasite diarrhea was more encountered during the rainy season (OR=0.41, 95% CI: 0.33 - 0.87, p=0.011). CONCLUSION: Giardia spp and rotavirus were the leading cause of acute diarrhea in Nanoro, Burkina Faso with a predominance of rotavirus in children less than 2 years. Parasite and viral diarrhea were the most pathogens associated with malaria. However, the high rate of negative stool samples suggests the need to determine other enteric microorganisms.},
note = {Copyright: Palpouguini Lompo et al.
PMID: 34104307
PMCID: PMC8164431},
keywords = {Abdominal Pain/epidemiology, Acute Disease, bacteria, Burkina Faso, Burkina Faso/epidemiology, Child, Comorbidity, Diarrhea, Diarrhea/epidemiology/microbiology, Female, Fever/epidemiology, Giardiasis/epidemiology, Humans, Infant, infectious, Malaria, Malaria/epidemiology, Male, parasite, pathogens, Preschool, Prevalence, Risk Factors, rotavirus, Rotavirus Infections/epidemiology, Rural Population, Seasons, Vomiting/epidemiology},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: acute diarrhea in children under five years is a public health problem in developing countries and particularly in malaria-endemic areas where both diseases co-exist. The present study examined the etiology of childhood diarrhea and its comorbidity with malaria in a rural area of Burkina Faso.
METHODS: conventional culture techniques, direct stools examination, and viruses´ detection by rapid tests were performed on the fresh stools and microscopy was used to diagnose malaria. Some risk factors were also assessed. RESULTS: on a total of 191 samples collected, at least one pathogen was identified in 89 cases (46.6%). The proportions of pathogens found on the 89 positive stool samples were parasites 51.69% (46 cases), viruses 39.33% (35 cases), and bacteria 14.61% (13 cases), respectively. The relationship between malaria and infectious diarrhea was significant in viral and parasites causes (p=0.005 and 0.043 respectively). Fever, vomiting and abdominal pain were the major symptoms associated with diarrhea, with 71.51%, 31.72% and 23.66% respectively. The highest viral diarrhea prevalence was reported during the dry season (OR=5.29, 95% CI: 1.74 – 16.07, p=0.001) while parasite diarrhea was more encountered during the rainy season (OR=0.41, 95% CI: 0.33 – 0.87, p=0.011). CONCLUSION: Giardia spp and rotavirus were the leading cause of acute diarrhea in Nanoro, Burkina Faso with a predominance of rotavirus in children less than 2 years. Parasite and viral diarrhea were the most pathogens associated with malaria. However, the high rate of negative stool samples suggests the need to determine other enteric microorganisms. |
| Paul Sondo, Biebo Bihoun, Marc Christian Tahita, Karim Derra, Toussaint Rouamba, Seydou Nakanabo Diallo, Adama Kazienga, Hamidou Ilboudo, Innocent Valea, Zekiba Tarnagda, Hermann Sorgho, Thierry Lef`evre, Halidou Tinto Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density (Journal Article) In: Malar. J., vol. 20, no. 1, pp. 31, 2021, ISSN: 1475-2875, (PMID: 33413393
PMCID: PMC7791700). @article{Sondo2021-at,
title = {Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density},
author = {Paul Sondo and Biebo Bihoun and Marc Christian Tahita and Karim Derra and Toussaint Rouamba and Seydou Nakanabo Diallo and Adama Kazienga and Hamidou Ilboudo and Innocent Valea and Zekiba Tarnagda and Hermann Sorgho and Thierry Lef`evre and Halidou Tinto},
doi = {10.1186/s12936-020-03559-0},
issn = {1475-2875},
year = {2021},
date = {2021-01-07},
urldate = {2021-01-01},
journal = {Malar. J.},
volume = {20},
number = {1},
pages = {31},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Multi-genotype malaria infections are frequent in
endemic area, and people commonly harbour several genetically
distinct Plasmodium falciparum variants. The influence of
genetic multiplicity and whether some specific genetic variants
are more or less likely to invest into gametocyte production is
not clearly understood. This study explored host and
parasite-related risk factors for gametocyte carriage, and the
extent to which some specific P. falciparum genetic variants are
associated with gametocyte carriage. METHODS: Gametocytes and
asexual forms were detected by light microscopy on thick smears
collected between 2010 and 2012 in Nanoro, Burkina Faso.
Merozoite surface protein 1 and 2 were genotyped by nested PCR
on clinical samples. Associations between gametocyte carriage
and factors, including multiplicity of infection, parasite
density, patient age, gender, haemoglobin (Hb) level, and body
temperature were assessed. The relationship between the presence
of a particular msp1 and msp2 genetic variants and gametocyte
carriage was also explored. RESULTS: Of the 724 samples positive
to P. falciparum and successfully genotyped, gametocytes were
found in 48 samples (6.63%). There was no effect of patient
gender, age and body temperature on gametocyte carriage.
However, the probability of gametocyte carriage significantly
increased with increasing values of multiplicity of infection
(MOI). Furthermore, there was a negative association between
parasite density and gametocyte carriage. MOI decreased with
parasite density in gametocyte-negative patients, but increased
in gametocyte carriers. The probability of gametocyte carriage
decreased with Hb level. Finally, the genetic composition of the
infection influenced gametocyte carriage. In particular, the
presence of RO33 increased the odds of developing gametocytes by
2 while the other allelic families K1, MAD20, FC27, and 3D7 had
no significant impact on the occurrence of gametocytes in
infected patients. CONCLUSION: This study provides insight into
potential factors influencing gametocyte production in
symptomatic patients. The findings contribute to enhance
understanding of risk factors associated with gametocyte
carriage in humans. Trial registration NCT01232530.},
note = {PMID: 33413393
PMCID: PMC7791700},
keywords = {Anemia/epidemiology/parasitology, Burkina Faso/epidemiology, Falciparum/epidemiology/parasitology, Gametocyte, Humans, Malaria, msp1, msp2, Multiplicity of infection, Plasmodium falciparum, Plasmodium falciparum/physiology},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Multi-genotype malaria infections are frequent in
endemic area, and people commonly harbour several genetically
distinct Plasmodium falciparum variants. The influence of
genetic multiplicity and whether some specific genetic variants
are more or less likely to invest into gametocyte production is
not clearly understood. This study explored host and
parasite-related risk factors for gametocyte carriage, and the
extent to which some specific P. falciparum genetic variants are
associated with gametocyte carriage. METHODS: Gametocytes and
asexual forms were detected by light microscopy on thick smears
collected between 2010 and 2012 in Nanoro, Burkina Faso.
Merozoite surface protein 1 and 2 were genotyped by nested PCR
on clinical samples. Associations between gametocyte carriage
and factors, including multiplicity of infection, parasite
density, patient age, gender, haemoglobin (Hb) level, and body
temperature were assessed. The relationship between the presence
of a particular msp1 and msp2 genetic variants and gametocyte
carriage was also explored. RESULTS: Of the 724 samples positive
to P. falciparum and successfully genotyped, gametocytes were
found in 48 samples (6.63%). There was no effect of patient
gender, age and body temperature on gametocyte carriage.
However, the probability of gametocyte carriage significantly
increased with increasing values of multiplicity of infection
(MOI). Furthermore, there was a negative association between
parasite density and gametocyte carriage. MOI decreased with
parasite density in gametocyte-negative patients, but increased
in gametocyte carriers. The probability of gametocyte carriage
decreased with Hb level. Finally, the genetic composition of the
infection influenced gametocyte carriage. In particular, the
presence of RO33 increased the odds of developing gametocytes by
2 while the other allelic families K1, MAD20, FC27, and 3D7 had
no significant impact on the occurrence of gametocytes in
infected patients. CONCLUSION: This study provides insight into
potential factors influencing gametocyte production in
symptomatic patients. The findings contribute to enhance
understanding of risk factors associated with gametocyte
carriage in humans. Trial registration NCT01232530. |
2020
|
Journal Articles
|
| Laura Skrip, Karim Derra, Mikaila Kaboré, Navideh Noori, Adama Gansané, Innocent Valéa, Halidou Tinto, Bicaba W Brice, Mollie Van Gordon, Brittany Hagedorn, Hervé Hien, Benjamin M Althouse, Edward A Wenger, André Lin Ouédraogo Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis (Journal Article) In: Int. J. Infect. Dis., vol. 101, pp. 194–200, 2020, ISSN: 1878-3511 1201-9712, (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
PMID: 32987177
PMCID: PMC7518969). @article{Skrip2020-fq,
title = {Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis},
author = {Laura Skrip and Karim Derra and Mikaila Kabor\'{e} and Navideh Noori and Adama Gansan\'{e} and Innocent Val\'{e}a and Halidou Tinto and Bicaba W Brice and Mollie Van Gordon and Brittany Hagedorn and Herv\'{e} Hien and Benjamin M Althouse and Edward A Wenger and Andr\'{e} Lin Ou\'{e}draogo},
doi = {10.1016/j.ijid.2020.09.1432},
issn = {1878-3511 1201-9712},
year = {2020},
date = {2020-12-01},
urldate = {2020-12-01},
journal = {Int. J. Infect. Dis.},
volume = {101},
pages = {194--200},
publisher = {Elsevier BV},
abstract = {BACKGROUND: Absolute numbers of COVID-19 cases and deaths
reported to date in the sub-Saharan Africa (SSA) region have
been significantly lower than those across the Americas, Asia
and Europe. As a result, there has been limited information
about the demographic and clinical characteristics of deceased
cases in the region, as well as the impacts of different case
management strategies. METHODS: Data from deceased cases
reported across SSA through 10 May 2020 and from hospitalized
cases in Burkina Faso through 15 April 2020 were analyzed.
Demographic, epidemiological and clinical information on
deceased cases in SSA was derived through a line-list of
publicly available information and, for cases in Burkina Faso,
from aggregate records at the Centre Hospitalier Universitaire
de Tengandogo in Ouagadougou. A synthetic case population was
probabilistically derived using distributions of age, sex and
underlying conditions from populations of West African countries
to assess individual risk factors and treatment effect sizes.
Logistic regression analysis was conducted to evaluate the
adjusted odds of survival for patients receiving oxygen therapy
or convalescent plasma, based on therapeutic effectiveness
observed for other respiratory illnesses. RESULTS: Across SSA,
deceased cases for which demographic data were available were
predominantly male (63/103, 61.2%) and aged \>50 years (59/75,
78.7%). In Burkina Faso, specifically, the majority of deceased
cases either did not seek care at all or were hospitalized for a
single day (59.4%, 19/32). Hypertension and diabetes were often
reported as underlying conditions. After adjustment for sex, age
and underlying conditions in the synthetic case population, the
odds of mortality for cases not receiving oxygen therapy were
significantly higher than for those receiving oxygen, such as
due to disruptions to standard care (OR 2.07; 95% CI
1.56-2.75). Cases receiving convalescent plasma had 50% reduced
odds of mortality than those who did not (95% CI 0.24-0.93).
CONCLUSIONS: Investment in sustainable production and
maintenance of supplies for oxygen therapy, along with messaging
around early and appropriate use for healthcare providers,
caregivers and patients could reduce COVID-19 deaths in SSA.
Further investigation into convalescent plasma is warranted
until data on its effectiveness specifically in treating
COVID-19 becomes available. The success of supportive or
curative clinical interventions will depend on earlier treatment
seeking, such that community engagement and risk communication
will be critical components of the response.},
note = {Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
PMID: 32987177
PMCID: PMC7518969},
keywords = {Adolescent, Adult, Africa South of the Sahara, Aged, Antiviral Agents/administration \& dosage, Asia/epidemiology, Burkina Faso, Burkina Faso/epidemiology, Child, Clinical management of SARS-CoV-2 infection: convalescent plasma, COVID-19/drug therapy/epidemiology/mortality/therapy, Europe/epidemiology, Female, Health systems strengthening, Humans, Immunization, Infant, Male, Mortality, Oxygen therapy, Pandemics, Passive, Preschool, Retrospective Studies, SARS-CoV-2 infection, SARS-CoV-2/drug effects/physiology, sub-Saharan Africa, Young Adult},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Absolute numbers of COVID-19 cases and deaths
reported to date in the sub-Saharan Africa (SSA) region have
been significantly lower than those across the Americas, Asia
and Europe. As a result, there has been limited information
about the demographic and clinical characteristics of deceased
cases in the region, as well as the impacts of different case
management strategies. METHODS: Data from deceased cases
reported across SSA through 10 May 2020 and from hospitalized
cases in Burkina Faso through 15 April 2020 were analyzed.
Demographic, epidemiological and clinical information on
deceased cases in SSA was derived through a line-list of
publicly available information and, for cases in Burkina Faso,
from aggregate records at the Centre Hospitalier Universitaire
de Tengandogo in Ouagadougou. A synthetic case population was
probabilistically derived using distributions of age, sex and
underlying conditions from populations of West African countries
to assess individual risk factors and treatment effect sizes.
Logistic regression analysis was conducted to evaluate the
adjusted odds of survival for patients receiving oxygen therapy
or convalescent plasma, based on therapeutic effectiveness
observed for other respiratory illnesses. RESULTS: Across SSA,
deceased cases for which demographic data were available were
predominantly male (63/103, 61.2%) and aged >50 years (59/75,
78.7%). In Burkina Faso, specifically, the majority of deceased
cases either did not seek care at all or were hospitalized for a
single day (59.4%, 19/32). Hypertension and diabetes were often
reported as underlying conditions. After adjustment for sex, age
and underlying conditions in the synthetic case population, the
odds of mortality for cases not receiving oxygen therapy were
significantly higher than for those receiving oxygen, such as
due to disruptions to standard care (OR 2.07; 95% CI
1.56-2.75). Cases receiving convalescent plasma had 50% reduced
odds of mortality than those who did not (95% CI 0.24-0.93).
CONCLUSIONS: Investment in sustainable production and
maintenance of supplies for oxygen therapy, along with messaging
around early and appropriate use for healthcare providers,
caregivers and patients could reduce COVID-19 deaths in SSA.
Further investigation into convalescent plasma is warranted
until data on its effectiveness specifically in treating
COVID-19 becomes available. The success of supportive or
curative clinical interventions will depend on earlier treatment
seeking, such that community engagement and risk communication
will be critical components of the response. |