CRUN

Publications

" Our main objective is to develop and maintain over time a good expertise and infrastructure ensuring high quality training and clinical research."
Prof Halidou TINTO, PharmD, Msc, PhD Head of the CRUN

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2021

Daniel Chandramohan; Issaka Zongo; Issaka Sagara; Matthew Cairns; Rakiswendé-Serge Yerbanga; Modibo Diarra; Frédéric Niki`ema; Amadou Tapily; Frédéric Sompougdou; Djibrilla Issiaka; Charles Zoungrana; Koualy Sanogo; Alassane Haro; Mahamadou Kaya; Abdoul-Aziz Sienou; Seydou Traore; Almahamoudou Mahamar; Ismaila Thera; Kalifa Diarra; Amagana Dolo; Irene Kuepfer; Paul Snell; Paul Milligan; Christian Ockenhouse; Opokua Ofori-Anyinam; Halidou Tinto; Abdoulaye Djimde; Jean-Bosco Ouédraogo; Alassane Dicko; Brian Greenwood

Seasonal malaria vaccination with or without seasonal malaria chemoprevention (Journal Article)

In: N. Engl. J. Med., 385 (11), pp. 1005–1017, 2021, ISSN: 1533-4406 0028-4793, (Copyright © 2021 Massachusetts Medical Society. Place: United States PMID: 34432975).

(Abstract | Links | BibTeX | Altmetric | Tags: Amodiaquine/therapeutic use, Antimalarials/adverse effects/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Combination, Combined Modality Therapy, Double-Blind Method, Drug Combinations, Drug Therapy, Falciparum/epidemiology/mortality/prevention & control, Febrile/etiology, Female, Hospitalization/statistics & numerical data, Humans, Infant, Malaria, Malaria Vaccines/administration & dosage/adverse effects, Male, Mali/epidemiology, Pyrimethamine/therapeutic use, Seasons, Seizures, Sulfadoxine/therapeutic use)

Seasonal malaria vaccination with or without seasonal malaria  chemoprevention

Stephen A Roberts; Loretta Brabin; Halidou Tinto; Sabine Gies; Salou Diallo; Bernard Brabin

Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data (Journal Article)

In: BMC Public Health, 21 (1), pp. 1764, 2021, ISSN: 1471-2458, (© 2021. The Author(s). PMID: 34579679 PMCID: PMC8477466).

(Abstract | Links | BibTeX | Altmetric | Tags: Abnormal vaginal flora, Adolescents, Bacterial vaginosis, Body Mass Index, Burkina Faso/epidemiology, Child, Female, Humans, Iron, iron biomarkers, Malaria, Malaria/drug therapy/epidemiology, MUAC, Pregnancy, Seasons, Vagina)

Seasonal patterns of malaria, genital infection, nutritional and  iron status in non-pregnant and pregnant adolescents in Burkina  Faso: a secondary analysis of trial data

Adéla"ide Compaoré; Kadija Ouedraogo; Palwende R Boua; Daniella Watson; Sarah H Kehoe; Marie-Louise Newell; Halidou Tinto; Mary Barker; Hermann Sorgho; INPreP group

‘Men are not playing their roles’, maternal and child nutrition in Nanoro, Burkina Faso (Journal Article)

In: Public Health Nutr., 24 (12), pp. 3780–3790, 2021, ISSN: 1475-2727 1368-9800, (Place: England PMID: 33000717).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Child, Child nutrition, Child Nutritional Physiological Phenomena, Community perceptions, Empowerment, Female, Humans, Male, Maternal nutrition, Mothers, Nutritional Status, Pregnancy, Qualitative research)

'Men are not playing their roles', maternal and child nutrition  in Nanoro, Burkina Faso

Marie Jaspard; Mamadou Saliou Sow; Sylvain Juchet; Eric Dienderé; Beatrice Serra; Richard Kojan; Billy Sivahera; Caroline Martin; Moumouni Kinda; Hans-Joerg Lang; Fodé Bangaly Sako; Fodé Amara Traoré; Eudoxie Koumbem; Halidou Tinto; Adama Sanou; Apoline Sondo; Flavien Kaboré; Joseph Donamou; Jean-Paul-Yassa Guilavogui; Fanny Velardo; Brice Bicaba; Olivier Marcy; Augustin Augier; Sani Sayadi; Armel Poda; Sakoba Keita; Xavier Anglaret; Denis Malvy; COVISTA group

Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa (Journal Article)

In: Int. J. Infect. Dis., 108 , pp. 45–52, 2021, ISSN: 1878-3511 1201-9712, (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. PMID: 34000419 PMCID: PMC8120805).

(Abstract | Links | BibTeX | Altmetric | Tags: Adult, Aged, Burkina Faso/epidemiology, Comorbidities, COVID-19, Female, Hospitalization, Humans, Male, Mortality, Prospective Studies, Referral and Consultation, SARS-Cov-2, sub-Saharan Africa)

Clinical presentation, outcomes and factors associated with  mortality: A prospective study from three COVID-19 referral  care centres in West Africa

Mariken Wit; Matthew Cairns; Yves Daniel Compaoré; Issaka Sagara; Irene Kuepfer; Issaka Zongo; Amadou Barry; Modibo Diarra; Amadou Tapily; Samba Coumare; Ismaila Thera; Frederic Nikiema; R Serge Yerbanga; Rosemonde M Guissou; Halidou Tinto; Alassane Dicko; Daniel Chandramohan; Brian Greenwood; Jean Bosco Ouedraogo

Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria (Journal Article)

In: Malar. J., 20 (1), pp. 274, 2021, ISSN: 1475-2875, (PMID: 34158054 PMCID: PMC8220741).

(Abstract | Links | BibTeX | Altmetric | Tags: Acute malnutrition, Antimalarials/administration & dosage, Azithromycin/administration & dosage, Burkina Faso, Burkina Faso/epidemiology, Child, Chronic malnutrition, Female, Humans, Incidence, Infant, Malaria, Malaria/epidemiology/transmission, Male, Nutritional Status, Preschool, seasonal malaria chemoprevention, Seasons)

Nutritional status in young children prior to the malaria  transmission season in Burkina Faso and Mali, and its impact on  the incidence of clinical malaria

Annelies Post; Berenger Kaboré; Mike Berendsen; Salou Diallo; Ousmane Traore; Rob J W Arts; Mihai G Netea; Leo A B Joosten; Halidou Tinto; Jan Jacobs; Quirijn Mast; André Ven

Altered ex-vivo cytokine responses in children with asymptomatic Plasmodium falciparum infection in Burkina Faso: An additional argument to treat asymptomatic malaria? (Journal Article)

In: Front. Immunol., 12 , pp. 614817, 2021, ISSN: 1664-3224, (Copyright © 2021 Post, Kaboré, Berendsen, Diallo, Traore, Arts, Netea, Joosten, Tinto, Jacobs, de Mast and van der Ven. PMID: 34177883 PMCID: PMC8220162).

(Abstract | Links | BibTeX | Altmetric | Tags: Asymptomatic Diseases, asymptomatic malaria, bacteraemia, Bacteremia, bloodstream infection, Burkina Faso/epidemiology, Cells, Child, Cultured, Cytokines/metabolism, Endemic Diseases, Female, Humans, Infant, iNTS, Lipopolysaccharides/immunology, Malaria/epidemiology/immunology, Male, Parasite Load, Plasmodium falciparum/physiology, Preschool, Salmonella)

Altered ex-vivo cytokine responses in children with asymptomatic  Plasmodium falciparum infection in Burkina Faso: An additional  argument to treat asymptomatic malaria?

Joel D Bognini; Sekou Samadoulougou; Mady Ouedraogo; Tiga David Kangoye; Carine Van Malderen; Halidou Tinto; Fati Kirakoya-Samadoulougou

Socioeconomic inequalities in curative healthcare-seeking for children under five before and after the free healthcare initiative in Sierra Leone: analysis of population-based survey data (Journal Article)

In: Int. J. Equity Health, 20 (1), pp. 124, 2021, ISSN: 1475-9276, (PMID: 34020665 PMCID: PMC8140517).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Adult, Child, Children under five, Delivery of Health Care/economics, Female, Health Care Surveys, Healthcare Disparities/economics/statistics & numerical data, Healthcare utilization, Humans, Infant, Male, Parents/psychology, Patient Acceptance of Health Care/statistics & numerical data, Preschool, Sierra Leone, Socioeconomic Factors, Young Adult)

Socioeconomic inequalities in curative healthcare-seeking for  children under five before and after the free healthcare  initiative in Sierra Leone: analysis of population-based survey  data

Yeka Adoke; Rella Zoleko-Manego; Serge Ouoba; Alfred B Tiono; Grace Kaguthi; Juv^encio Eduardo Bonzela; Tran Thanh Duong; Alain Nahum; Marielle Bouyou-Akotet; Bernhards Ogutu; Alphonse Ouedraogo; Fiona Macintyre; Andreas Jessel; Bart Laurijssens; Mohammed H Cherkaoui-Rbati; Cathy Cantalloube; Anne Claire Marrast; Rapha"el Bejuit; David White; Timothy N C Wells; Florian Wartha; Didier Leroy; Afizi Kibuuka; Ghyslain Mombo-Ngoma; Daouda Ouattara; Ir`ene Mugenya; Bui Quang Phuc; Francis Bohissou; Denise P Mawili-Mboumba; Fredrick Olewe; Issiaka Soulama; Halidou Tinto; FALCI Study Group

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria (Journal Article)

In: Malar. J., 20 (1), pp. 222, 2021, ISSN: 1475-2875, (PMID: 34011358 PMCID: PMC8135182).

(Abstract | Links | BibTeX | Altmetric | Tags: Adamantane/administration & dosage/analogs & derivatives, Adolescent, Adult, Aged, Aminoquinolines/administration & dosage, Benin, Burkina Faso, C580Y, Child, Combination treatment, Double-Blind Method, Drug Combinations, Exposure–response, Falciparum/prevention & control, Female, Ferroquine, Ferrous Compounds/administration & dosage, Gabon, Humans, Infant, Kelch-13 mutation, Kenya, Malaria, Male, Metallocenes/administration & dosage, Middle Aged, Mozambique, Parasite clearance, Peroxides/administration & dosage, Pharmacokinetics/pharmacodynamics, Plasmodium falciparum/drug effects, Preschool, resistance, Uganda, Vietnam, Vomiting, Young Adult)

A randomized, double-blind, phase 2b study to investigate the  efficacy, safety, tolerability and pharmacokinetics of a  single-dose regimen of ferroquine with artefenomel in adults and  children with uncomplicated Plasmodium falciparum malaria

Mehreen S Datoo; Magloire H Natama; Athanase Somé; Ousmane Traoré; Toussaint Rouamba; Duncan Bellamy; Prisca Yameogo; Daniel Valia; Moubarak Tegneri; Florence Ouedraogo; Rachidatou Soma; Seydou Sawadogo; Faizatou Sorgho; Karim Derra; Eli Rouamba; Benedict Orindi; Fernando Ramos Lopez; Amy Flaxman; Federica Cappuccini; Reshma Kailath; Sean Elias; Ekta Mukhopadhyay; Andres Noe; Matthew Cairns; Alison Lawrie; Rachel Roberts; Innocent Valéa; Hermann Sorgho; Nicola Williams; Gregory Glenn; Louis Fries; Jenny Reimer; Katie J Ewer; Umesh Shaligram; Adrian V S Hill; Halidou Tinto

Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial (Journal Article)

In: Lancet, 397 (10287), pp. 1809–1818, 2021, ISSN: 1474-547X 0140-6736, (Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. PMID: 33964223 PMCID: PMC8121760).

(Abstract | Links | BibTeX | Altmetric | Tags: Adjuvants, Burkina Faso, Double-Blind Method, Falciparum/prevention & control, Female, Hepatitis B Surface Antigens, Humans, Immunogenicity, Immunologic/administration & dosage, Infant, Malaria, Malaria Vaccines/therapeutic use, Malaria/prevention & control, Male, Nanoparticles/administration & dosage, Proportional Hazards Models, Protozoan Proteins/immunology, Saponins/administration & dosage, Treatment Outcome, Vaccine, Vaccines, Virus-Like Particle/therapeutic use)

Efficacy of a low-dose candidate malaria vaccine, R21 in  adjuvant Matrix-M, with seasonal administration to children in  Burkina Faso: a randomised controlled trial

Toussaint Rouamba; Sékou Samadoulougou; Mady Ouédraogo; Hervé Hien; Halidou Tinto; Fati Kirakoya-Samadoulougou

Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017 (Journal Article)

In: Malar. J., 20 (1), pp. 211, 2021, ISSN: 1475-2875.

(Abstract | Links | BibTeX | Altmetric | Tags: Adult, Anemia/epidemiology/parasitology, Asymptomatic carriage, Asymptomatic Infections/epidemiology, Burkina Faso/epidemiology, Community, Cross-Sectional Studies, Female, Haemoglobin, Humans, Malaria/epidemiology/parasitology, Parasitic/epidemiology/parasitology, Plasmodium, Pregnancy, Pregnancy Complications, Pregnant, Pregnant Women, Prevalence, Young Adult)

Asymptomatic malaria and anaemia among pregnant women during  high and low malaria transmission seasons in Burkina Faso:  household-based cross-sectional surveys in Burkina Faso, 2013  and 2017

Sabine Gies; Stephen A Roberts; Salou Diallo; Olga M Lompo; Halidou Tinto; Bernard J Brabin

Risk of malaria in young children after periconceptional iron supplementation (Journal Article)

In: Matern. Child Nutr., 17 (2), pp. e13106, 2021, ISSN: 1740-8709 1740-8695, (© 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. PMID: 33236840 PMCID: PMC7988873).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, child iron, Dietary Supplements/analysis, Female, Folic Acid, Humans, Infant, Malaria, Newborn, periconceptional, placenta, Pregnancy, Premature Birth, Preschool)

Risk of malaria in young children after periconceptional iron  supplementation

Engelbert A Nonterah; Michiel L Bots; Abraham Oduro; Godfred Agongo; Cassandra C Soo; Lisa K Micklesfield; Felistas Mashinya; Palwendé R Boua; Shukri F Mohamed; Alisha N Wade; Catherine Kyobutungi; Halidou Tinto; Shane A Norris; Stephen M Tollman; Mich`ele Ramsay; Diederick E Grobbee; Kerstin Klipstein-Grobusch; Nigel J Crowther; AWI-Gen; H3Africa Consortium

Adiposity phenotypes and subclinical atherosclerosis in adults from sub-Saharan Africa: An H3Africa AWI-gen study (Journal Article)

In: Glob. Heart, 16 (1), pp. 19, 2021, ISSN: 2211-8179 2211-8160, (Copyright: © 2021 The Author(s). PMID: 33833943 PMCID: PMC7977036).

(Abstract | Links | BibTeX | Altmetric | Tags: adiposity, Adult, Body Mass Index, cardiovascular disease, Carotid intima-media thickness, Cross-Sectional Studies, Female, Ghana, Humans, Male, Middle Aged, obesity, Obesity/complications/epidemiology, Phenotype, Risk Factors, sub-Saharan Africa, subclinical atherosclerosis)

Adiposity phenotypes and subclinical atherosclerosis in adults  from sub-Saharan Africa: An H3Africa AWI-gen study

Annelies Post; Berenger Kaboré; Joel Bognini; Salou Diallo; Palpouguini Lompo; Basile Kam; Natacha Herssens; Fred Opzeeland; Christa E Gaast-de Jongh; Jeroen D Langereis; Marien I Jonge; Janette Rahamat-Langendoen; Teun Bousema; Heiman Wertheim; Robert W Sauerwein; Halidou Tinto; Jan Jacobs; Quirijn Mast; Andre J Ven

Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso (Journal Article)

In: PLoS Negl. Trop. Dis., 15 (3), pp. e0009187, 2021, ISSN: 1935-2735 1935-2727, (PMID: 33647009 PMCID: PMC7951874).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Automation, Bacteremia/diagnosis, Burkina Faso, C-Reactive Protein/analysis, Child, Coinfection/diagnosis/microbiology/parasitology, Female, Fever of Unknown Origin/diagnosis, Humans, Infant, Laboratory/methods, Malaria/diagnosis, Male, Preschool, Procalcitonin/analysis, Prospective Studies, Sensitivity and Specificity, Software, Virus Diseases/diagnosis)

Infection Manager System (IMS) as a new hemocytometry-based  bacteremia detection tool: A diagnostic accuracy study in a  malaria-endemic area of Burkina Faso

Palpouguini Lompo; Marc Christian Tahita; Hermann Sorgho; William Kaboré; Adama Kazienga; Ashmed Cheick Bachirou Nana; Hamtandi Magloire Natama; Isidore Juste Ouindgueta Bonkoungou; Nicolas Barro; Halidou Tinto

Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso (Journal Article)

In: Pan Afr. Med. J., 38 , pp. 259, 2021, ISSN: 1937-8688, (Copyright: Palpouguini Lompo et al. PMID: 34104307 PMCID: PMC8164431).

(Abstract | Links | BibTeX | Altmetric | Tags: Abdominal Pain/epidemiology, Acute Disease, bacteria, Burkina Faso, Burkina Faso/epidemiology, Child, Comorbidity, Diarrhea, Diarrhea/epidemiology/microbiology, Female, Fever/epidemiology, Giardiasis/epidemiology, Humans, Infant, infectious, Malaria, Malaria/epidemiology, Male, parasite, pathogens, Preschool, Prevalence, Risk Factors, rotavirus, Rotavirus Infections/epidemiology, Rural Population, Seasons, Vomiting/epidemiology)

Pathogens associated with acute diarrhea, and comorbidity with  malaria among children under five years old in rural Burkina  Faso

Hamatandi Magloire Natama; Eduard Rovira-Vallbona; Meryam Krit; Pieter Guetens; Hermann Sorgho; M Athanase Somé; Maminata Traoré-Coulibaly; Innocent Valéa; Petra F Mens; Henk D F H Schallig; Dirk Berkvens; Luc Kestens; Halidou Tinto; Anna Rosanas-Urgell

Genetic variation in the immune system and malaria susceptibility in infants: a nested case-control study in Nanoro, Burkina Faso (Journal Article)

In: Malar. J., 20 (1), pp. 94, 2021, ISSN: 1475-2875, (PMID: 33593344 PMCID: PMC7885350).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Case-Control Studies, Cytokines, Falciparum/parasitology, Female, Genetic Predisposition to Disease/genetics, Humans, Immunity, Immunogenetic variants, Infant, Innate immunity, Innate/genetics, Malaria, Male, Plasmodium falciparum, Plasmodium falciparum/physiology)

Genetic variation in the immune system and malaria  susceptibility in infants: a nested case-control study in  Nanoro, Burkina Faso

Adama Gansané; Leah F Moriarty; Didier Ménard; Isidore Yerbanga; Esperance Ouedraogo; Paul Sondo; Rene Kinda; Casimir Tarama; Edwige Soulama; Madou Tapsoba; David Kangoye; Cheick Said Compaore; Ousmane Badolo; Blami Dao; Samuel Tchwenko; Halidou Tinto; Innocent Valea

Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017-2018 (Journal Article)

In: Malar. J., 20 (1), pp. 48, 2021, ISSN: 1475-2875.

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarial, Antimalarials/pharmacology, Artemether, Artemether-lumefantrine, Artemisinins/pharmacology, Burkina Faso, Child, Dihydroartemisinin-piperaquine, Drug Resistance, Efficacy, Falciparum/drug therapy, Female, Lumefantrine Drug Combination/pharmacology, Malaria, Male, Plasmodium falciparum, Preschool, Quinolines/pharmacology)

Anti-malarial efficacy and resistance monitoring of  artemether-lumefantrine and dihydroartemisinin-piperaquine shows  inadequate efficacy in children in Burkina Faso, 2017-2018

2020

Laura Skrip; Karim Derra; Mikaila Kaboré; Navideh Noori; Adama Gansané; Innocent Valéa; Halidou Tinto; Bicaba W Brice; Mollie Van Gordon; Brittany Hagedorn; Hervé Hien; Benjamin M Althouse; Edward A Wenger; André Lin Ouédraogo

Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis (Journal Article)

In: Int. J. Infect. Dis., 101 , pp. 194–200, 2020, ISSN: 1878-3511 1201-9712, (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. PMID: 32987177 PMCID: PMC7518969).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Adult, Africa South of the Sahara, Aged, Antiviral Agents/administration & dosage, Asia/epidemiology, Burkina Faso, Burkina Faso/epidemiology, Child, Clinical management of SARS-CoV-2 infection: convalescent plasma, COVID-19/drug therapy/epidemiology/mortality/therapy, Europe/epidemiology, Female, Health systems strengthening, Humans, Immunization, Infant, Male, Mortality, Oxygen therapy, Pandemics, Passive, Preschool, Retrospective Studies, SARS-CoV-2 infection, SARS-CoV-2/drug effects/physiology, sub-Saharan Africa, Young Adult)

Clinical management and mortality among COVID-19 cases in  sub-Saharan Africa: A retrospective study from Burkina Faso and  simulated case analysis