Publications

@article{Lingani2021-is,

title = {Malaria and curable sexually transmitted and reproductive tract  coinfection among pregnant women in rural Burkina Faso},

author = {Moussa Lingani and Serge H Zango and Innocent Val\'{e}a and Massa Dit A Bonko and S\'{e}kou O Samadoulougou and Toussaint Rouamba and Marc C Tahita and Ma"imouna Sanou and Annie Robert and Halidou Tinto and Philippe Donnen and Mich`ele Dramaix},

doi = {10.1186/s41182-021-00381-5},

issn = {1348-8945 1349-4147},

year  = {2021},

date = {2021-11-01},

urldate = {2021-11-01},

journal = {Trop. Med. Health},

volume = {49},

number = {1},

pages = {90},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Malaria and sexually transmitted/reproductive tract 

 infections (STI/RTI) are leading and preventable causes of low 

 birthweight in sub-Saharan Africa. Reducing their impact on 

 pregnancy outcomes requires efficient interventions that can be 

 easily integrated into the antenatal care package. The paucity 

 of data on malaria and STI/RTI coinfection, however, limits 

 efforts to control these infections. This study aimed to 

 determine the prevalence and associated factors of malaria and 

 STI/RTI coinfection among pregnant women in rural Burkina Faso. 

 METHODS: A cross-sectional survey was conducted among 402 

 pregnant women attending antenatal clinics at the Yako health 

 district. Sociodemographic and behavioral data were collected, 

 and pregnant women were tested for peripheral malaria by 

 microscopy. Hemoglobin levels were also measured by 

 spectrophotometry and curable bacterial STI/RTI were tested on 

 cervico-vaginal swabs using rapid diagnostic test for chlamydia 

 and syphilis, and Gram staining for bacterial vaginosis. A 

 multivariate logistic regression model was used to assess the 

 association of malaria and STI/RTI coinfection with the 

 characteristics of included pregnant women. RESULTS: The 

 prevalence of malaria and at least one STI/RTI coinfection was 

 12.9% (95% confidence interval, CI: [9.8-16.7]), malaria and 

 bacterial vaginosis coinfection was 12.2% (95% CI: 

 [9.3-15.9]), malaria and chlamydial coinfection was 1.6% (95% 

 CI: [0.6-3.8]). No coinfection was reported for malaria and 

 syphilis. The individual prevalence was 17.2%, 7.2%, 0.6%, 

 67.7% and 73.3%, respectively, for malaria infection, 

 chlamydia, syphilis, bacterial vaginosis and STI/RTI 

 combination. Only 10% of coinfections were symptomatic, and 

 thus, 90% of women with coinfection would have been missed by 

 the symptoms-based diagnostic approach. In the multivariate analysis, the first pregnancy (aOR = 2.4 [95% CI: 1.2-4.7]) was 

 the only factor significantly associated with malaria and 

 STI/RTI coinfection. Clinical symptoms were not associated with 

 malaria and STI/RTI coinfection. CONCLUSION: The prevalence of 

 malaria and curable STI/RTI coinfection was high among pregnant 

 women. The poor performance of the clinical symptoms to predict 

 coinfection suggests that alternative interventions are needed.},

note = {© 2021. The Author(s).

PMID: 34736524 

PMCID: PMC8567650},

keywords = {Bacterial vaginosis, Burkina Faso, Chlamydia, Coinfection, Malaria, Pregnancy, Syphilis},

pubstate = {published},

tppubtype = {article}

}

@article{Roberts2021-gg,

title = {Seasonal patterns of malaria, genital infection, nutritional and  iron status in non-pregnant and pregnant adolescents in Burkina  Faso: a secondary analysis of trial data},

author = {Stephen A Roberts and Loretta Brabin and Halidou Tinto and Sabine Gies and Salou Diallo and Bernard Brabin},

doi = {10.1186/s12889-021-11819-0},

issn = {1471-2458},

year  = {2021},

date = {2021-09-01},

urldate = {2021-09-01},

journal = {BMC Public Health},

volume = {21},

number = {1},

pages = {1764},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Adolescents are considered at high risk of developing iron deficiency. Studies in children indicate that the prevalence of iron deficiency increased with  malaria transmission, suggesting malaria seasonally may drive iron deficiency. This  paper examines monthly seasonal infection patterns of malaria, abnormal vaginal  flora, chorioamnionitis, antibiotic and antimalarial prescriptions, in relation to  changes in iron biomarkers and nutritional indices in adolescents living in a rural  area of Burkina Faso, in order to assess the requirement for seasonal infection  control and nutrition interventions. METHODS: Data collected between April 2011 and  January 2014 were available for an observational seasonal analysis, comprising  scheduled visits for 1949 non-pregnant adolescents (≤19 years), (315 of whom  subsequently became pregnant), enrolled in a randomised trial of periconceptional  iron supplementation. Data from trial arms were combined. Body Iron Stores (BIS)  were calculated using an internal regression for ferritin to allow for inflammation.  At recruitment 11% had low BIS (\< 0 mg/kg). Continuous outcomes were fitted to a  mixed-effects linear model with month, age and pregnancy status as fixed effect  covariates and woman as a random effect. Dichotomous infection outcomes were fitted  with analogous logistic regression models. RESULTS: Seasonal variation in malaria  parasitaemia prevalence ranged between 18 and 70% in non-pregnant adolescents  (P \< 0.001), peaking at 81% in those who became pregnant. Seasonal variation  occurred in antibiotic prescription rates (0.7-1.8 prescriptions/100 weekly visits,  P \< 0.001) and chorioamnionitis prevalence (range 15-68%, P = 0.026). Mucosal  vaginal lactoferrin concentration was lower at the end of the wet season (range  2-22 μg/ml, P \< 0.016), when chorioamnionitis was least frequent. BIS fluctuated  annually by up to 53.2% per year around the mean BIS (5.1 mg/kg(2), range  4.1-6.8 mg/kg), with low BIS (\< 0 mg/kg) of 8.7% in the dry and 9.8% in the wet  seasons (P = 0.36). Median serum transferrin receptor increased during the wet  season (P \< 0.001). Higher hepcidin concentration in the wet season corresponded  with rising malaria prevalence and use of prescriptions, but with no change in BIS.  Mean Body Mass Index and Mid-Upper-Arm-Circumference values peaked mid-dry season  (both P \< 0.001). CONCLUSIONS: Our analysis supports preventive treatment of malaria  among adolescents 15-19 years to decrease their disease burden, especially  asymptomatic malaria. As BIS were adequate in most adolescents despite seasonal  malaria, a requirement for programmatic iron supplementation was not substantiated.},

note = {© 2021. The Author(s).

PMID: 34579679 

PMCID: PMC8477466},

keywords = {Abnormal vaginal flora, Adolescents, Bacterial vaginosis, Body Mass Index, Burkina Faso/epidemiology, Child, Female, Humans, Iron, iron biomarkers, Malaria, Malaria/drug therapy/epidemiology, MUAC, Pregnancy, Seasons, Vagina},

pubstate = {published},

tppubtype = {article}

}