CRUN

Publications

" Our main objective is to develop and maintain over time a good expertise and infrastructure ensuring high quality training and clinical research."
Prof Halidou TINTO, PharmD, Msc, PhD Head of the CRUN

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33 entries « 1 of 2 »

2022

Journal Articles

Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.

Palwende Romuald Boua, Jean-Tristan Brandenburg, Ananyo Choudhury, Hermann Sorgho, Engelbert A. Nonterah, Godfred Agongo, Gershim Asiki, Lisa Micklesfield, Solomon Choma, Francesc Xavier Gómez-Olivé, Scott Hazelhurst, Halidou Tinto, Nigel J. Crowther, Christopher G. Mathew, Michèle Ramsay

Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans. (Journal Article)

In: Nature communications, vol. 13, iss. 1, pp. 855, 2022.

(Abstract | Links | BibTeX | Altmetric | Tags: Adult, Africa South of the Sahara, Atherosclerosis/*genetics/*pathology, Autoantigens/genetics, Cardiovascular Diseases/genetics, Carotid Intima-Media Thickness/*statistics & numerical data, Endocrine-Gland-Derived/genetics, Female, Gastrointestinal Hormones/genetics, Genetic Predisposition to Disease/*genetics, Genome/genetics, Histones/genetics, Humans, Male, Middle Aged, Polymorphism, Ribonucleoproteins/genetics, Sex Factors, Single Nucleotide/genetics, Sorting Nexins/genetics, Vascular Endothelial Growth Factor)

Impact of seasonal RTS,S/AS01(E) vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali.

Jane Grant, Issaka Sagara, Issaka Zongo, Matthew Cairns, Rakiswendé Serge Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Frédéric Nikièma, Frédéric Sompougdou, Amadou Tapily, Mahamadou Kaya, Alassane Haro, Koualy Sanogo, Abdoul Aziz Sienou, Seydou Traore, Ismaila Thera, Hama Yalcouye, Irene Kuepfer, Paul Snell, Paul Milligan, Christian Ockenhouse, Opokua Ofori-Anyinam, Halidou Tinto, Abdoulaye Djimde, Daniel Chandramohan, Brian Greenwood, Alassane Dicko, Jean-Bosco Ouédraogo

Impact of seasonal RTS,S/AS01(E) vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali. (Journal Article)

In: Malaria journal, vol. 21, iss. 1, pp. 59, 2022.

(Abstract | Links | BibTeX | Altmetric | Tags: *Antimalarials/therapeutic use, *Malaria/drug therapy/epidemiology/prevention & control, Burkina Faso, Burkina Faso/epidemiology, Chemoprevention, Child, Cross-Sectional Studies, Humans, Infant, Malaria, Mali, Mali/epidemiology, Nutrition, Nutritional Status, Preschool, RTS, S/AS01E, seasonal malaria chemoprevention, Seasons, Vaccination)

Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa.

Estomih Mduma, Tinto Halidou, Berenger Kaboré, Thomas Walongo, Palpouguini Lompo, Justine Museveni, Joshua Gidabayda, Jean Gratz, Godfrey Guga, Caroline Kimathi, Jie Liu, Paschal Mdoe, Robert Moshiro, Max Petzold, Jan Singlovic, Martine Guillerm, Melba F. Gomes, Eric R. Houpt, Christine M. Halleux

Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa. (Journal Article)

In: PloS one, vol. 17, iss. 2, pp. e0264322, 2022.

(Abstract | Links | BibTeX | Altmetric | Tags: *Rural Population, Africa South of the Sahara/epidemiology, Bacterial Infections/*epidemiology/*etiology/*microbiology, Female, Humans, Infant, Male, Newborn, Patient Acuity)

Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study.

Liesbeth Martens, Bérenger Kaboré, Annelies Post, Christa E. Gaast-de Jongh, Jeroen D. Langereis, Halidou Tinto, Jan Jacobs, André J. Ven, Quirijn Mast, Marien I. Jonge

Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study. (Journal Article)

In: BMC infectious diseases, vol. 22, iss. 1, pp. 15, 2022.

(Abstract | Links | BibTeX | Altmetric | Tags: *Carrier State/epidemiology, *Staphylococcus aureus, Adult, Burkina Faso, Burkina Faso/epidemiology, Child, Female, Haemophilus influenzae, Humans, Infant, Klebsiella pneumoniae, Male, Moraxella catarrhalis, Nasopharyngeal carriage, Nasopharynx, Staphylococcus aureus, Streptococcus pneumoniae)

2021

Journal Articles

Ongoing and future COVID-19 vaccine clinical trials: challenges  and opportunities

Rafael Dal-Ré, Linda-Gail Bekker, Christian Gluud, Søren Holm, Vivekanand Jha, Gregory A Poland, Frits R Rosendaal, Brigitte Schwarzer-Daum, Esperanc ca Sevene, Halidou Tinto, Teck Chuan Voo, Nadarajah Sreeharan

Ongoing and future COVID-19 vaccine clinical trials: challenges and opportunities (Journal Article)

In: Lancet Infect. Dis., vol. 21, no. 11, pp. e342–e347, 2021, ISSN: 1474-4457 1473-3099, (Copyright © 2021 Elsevier Ltd. All rights reserved. PMID: 34019801 PMCID: PMC8131060).

(Abstract | Links | BibTeX | Altmetric | Tags: Clinical Trials as Topic, COVID-19 Vaccines/administration & dosage/immunology, COVID-19/epidemiology/immunology/prevention & control/virology, Double-Blind Method, Humans, Immunogenicity, Pandemics/prevention & control, SARS-CoV-2/immunology, Vaccine)

Epidemiologic profile of hepatitis C virus infection and  genotype distribution in Burkina Faso: a systematic review with  meta-analysis

Serge Ouoba, Jean Claude Romaric Pingdwinde Ouedraogo, Moussa Lingani, Bunthen E, Md Razeen Ashraf Hussain, Ko Ko, Shintaro Nagashima, Aya Sugiyama, Tomoyuki Akita, Halidou Tinto, Junko Tanaka

Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis (Journal Article)

In: BMC Infect. Dis., vol. 21, no. 1, pp. 1126, 2021, ISSN: 1471-2334, (© 2021. The Author(s). PMID: 34724902 PMCID: PMC8561994).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Burkina Faso/epidemiology, Genotype, Hepacivirus/genetics, Hepatitis C, Hepatitis C/epidemiology, Humans, Prevalence, Seroepidemiologic Studies, Seroprevalence, Systematic review)

The duration of protection from azithromycin against malaria,  acute respiratory, gastrointestinal, and skin infections when  given alongside seasonal malaria chemoprevention: Secondary  analyses of data from a clinical trial in houndé, Burkina  Faso, and bougouni, Mali

Mphatso Dennis Phiri, Matthew Cairns, Issaka Zongo, Frederic Nikiema, Modibo Diarra, Rakiswendé Serge Yerbanga, Amadou Barry, Amadou Tapily, Samba Coumare, Ismaila Thera, Irene Kuepfer, Paul Milligan, Halidou Tinto, Alassane Dicko, Jean Bosco Ouédraogo, Brian Greenwood, Daniel Chandramohan, Issaka Sagara

The duration of protection from azithromycin against malaria, acute respiratory, gastrointestinal, and skin infections when given alongside seasonal malaria chemoprevention: Secondary analyses of data from a clinical trial in houndé, Burkina Faso, and bougouni, Mali (Journal Article)

In: Clin. Infect. Dis., vol. 73, no. 7, pp. e2379–e2386, 2021, ISSN: 1537-6591 1058-4838, (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. PMID: 33417683 PMCID: PMC8492219).

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarials/therapeutic use, Azithromycin, Azithromycin/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Child, child mortality, Drug Combinations, duration of protection, Humans, Infant, Malaria/drug therapy/epidemiology/prevention & control, Mali/epidemiology, Preschool, Sahel, seasonal malaria chemoprevention, Seasons)

Seasonal malaria vaccination with or without seasonal malaria  chemoprevention

Daniel Chandramohan, Issaka Zongo, Issaka Sagara, Matthew Cairns, Rakiswendé-Serge Yerbanga, Modibo Diarra, Frédéric Niki`ema, Amadou Tapily, Frédéric Sompougdou, Djibrilla Issiaka, Charles Zoungrana, Koualy Sanogo, Alassane Haro, Mahamadou Kaya, Abdoul-Aziz Sienou, Seydou Traore, Almahamoudou Mahamar, Ismaila Thera, Kalifa Diarra, Amagana Dolo, Irene Kuepfer, Paul Snell, Paul Milligan, Christian Ockenhouse, Opokua Ofori-Anyinam, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouédraogo, Alassane Dicko, Brian Greenwood

Seasonal malaria vaccination with or without seasonal malaria chemoprevention (Journal Article)

In: N. Engl. J. Med., vol. 385, no. 11, pp. 1005–1017, 2021, ISSN: 1533-4406 0028-4793, (Copyright © 2021 Massachusetts Medical Society. Place: United States PMID: 34432975).

(Abstract | Links | BibTeX | Altmetric | Tags: Amodiaquine/therapeutic use, Antimalarials/adverse effects/therapeutic use, Burkina Faso/epidemiology, Chemoprevention, Combination, Combined Modality Therapy, Double-Blind Method, Drug Combinations, Drug Therapy, Falciparum/epidemiology/mortality/prevention & control, Febrile/etiology, Female, Hospitalization/statistics & numerical data, Humans, Infant, Malaria, Malaria Vaccines/administration & dosage/adverse effects, Male, Mali/epidemiology, Pyrimethamine/therapeutic use, Seasons, Seizures, Sulfadoxine/therapeutic use)

COVID-19 epidemiological, sociological and anthropological  investigation: study protocol for a multidisciplinary mixed  methods research in Burkina Faso

Isidore Tiandiogo Traoré, Samiratou Ouedraogo, Dramane Kania, Firmin Nongodo Kaboré, Blahima Konaté, Rachel Médah, Hermann Badolo, Nathalie Rekeneire, Ariane Mamguem Kamga, Armel Poda, Arnaud Eric Diendere, Boukary Ouédraogo, Esperance Ouédraogo, Oumar Billa, Halidou Tinto, Tienhan Sandrine Dabakuyo-Yonli

COVID-19 epidemiological, sociological and anthropological investigation: study protocol for a multidisciplinary mixed methods research in Burkina Faso (Journal Article)

In: BMC Infect. Dis., vol. 21, no. 1, pp. 896, 2021, ISSN: 1471-2334, (© 2021. The Author(s). PMID: 34479501 PMCID: PMC8414025).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso/epidemiology, Clinical epidemiology, COVID-19, Humans, Predictive score, Prospective Studies, Retrospective Studies, SARS-Cov-2, Sero-epidemiology, Socio-anthropology)

Seasonal patterns of malaria, genital infection, nutritional and  iron status in non-pregnant and pregnant adolescents in Burkina  Faso: a secondary analysis of trial data

Stephen A Roberts, Loretta Brabin, Halidou Tinto, Sabine Gies, Salou Diallo, Bernard Brabin

Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data (Journal Article)

In: BMC Public Health, vol. 21, no. 1, pp. 1764, 2021, ISSN: 1471-2458, (© 2021. The Author(s). PMID: 34579679 PMCID: PMC8477466).

(Abstract | Links | BibTeX | Altmetric | Tags: Abnormal vaginal flora, Adolescents, Bacterial vaginosis, Body Mass Index, Burkina Faso/epidemiology, Child, Female, Humans, Iron, iron biomarkers, Malaria, Malaria/drug therapy/epidemiology, MUAC, Pregnancy, Seasons, Vagina)

'Men are not playing their roles', maternal and child nutrition  in Nanoro, Burkina Faso

Adéla"ide Compaoré, Kadija Ouedraogo, Palwende R Boua, Daniella Watson, Sarah H Kehoe, Marie-Louise Newell, Halidou Tinto, Mary Barker, Hermann Sorgho, INPreP group

‘Men are not playing their roles’, maternal and child nutrition in Nanoro, Burkina Faso (Journal Article)

In: Public Health Nutr., vol. 24, no. 12, pp. 3780–3790, 2021, ISSN: 1475-2727 1368-9800, (Place: England PMID: 33000717).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Child, Child nutrition, Child Nutritional Physiological Phenomena, Community perceptions, Empowerment, Female, Humans, Male, Maternal nutrition, Mothers, Nutritional Status, Pregnancy, Qualitative research)

Effect of seasonal malaria chemoprevention plus azithromycin on  Plasmodium falciparum transmission: gametocyte infectivity and  mosquito fitness

Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Seydou Bienvenu Ouattara, Franck A Yao, Thierry Lef`evre, Issaka Zongo, Frederic Niki`ema, Yves Daniel Compaoré, Halidou Tinto, Daniel Chandramohan, Brian Greenwood, Adrien M G Belem, Anna Cohuet, Jean Bosco Ouédraogo

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness (Journal Article)

In: Malar. J., vol. 20, no. 1, pp. 326, 2021, ISSN: 1475-2875, (© 2021. The Author(s). PMID: 34315475 PMCID: PMC8314489).

(Abstract | Links | BibTeX | Altmetric | Tags: Amodiaquine/administration & dosage, Animals, Antimalarials/administration & dosage, Chemoprevention, Child, Culicidae/physiology, Drug Combinations, Falciparum/prevention & control/transmission, Gametocytes, Genetic Fitness, Humans, Malaria, Plasmodium falciparum/physiology, Preschool, Pyrimethamine/administration & dosage, seasonal malaria chemoprevention, Seasons, Sulfadoxine/administration & dosage, Transmission)

Patterns of child mortality in rural area of Burkina Faso:  evidence from the Nanoro health and demographic surveillance  system (HDSS)

Navideh Noori, Karim Derra, Innocent Valea, Assaf P Oron, Aminata Welgo, Toussaint Rouamba, Palwende Romuald Boua, Athanase M Somé, Eli Rouamba, Edward Wenger, Hermann Sorgho, Halidou Tinto, Andre Lin Ouédraogo

Patterns of child mortality in rural area of Burkina Faso: evidence from the Nanoro health and demographic surveillance system (HDSS) (Journal Article)

In: BMC Public Health, vol. 21, no. 1, pp. 1425, 2021, ISSN: 1471-2458, (© 2021. The Author(s). PMID: 34281547 PMCID: PMC8287796).

(Abstract | Links | BibTeX | Altmetric | Tags: Burkina Faso, Burkina Faso/epidemiology, child mortality, ChildHealth Facilities, Children under 5, Demographic surveillance, HDSS, Humans, Infant, Malaria, Nanoro, Spatial analysis, Travel)

Clinical presentation, outcomes and factors associated with  mortality: A prospective study from three COVID-19 referral  care centres in West Africa

Marie Jaspard, Mamadou Saliou Sow, Sylvain Juchet, Eric Dienderé, Beatrice Serra, Richard Kojan, Billy Sivahera, Caroline Martin, Moumouni Kinda, Hans-Joerg Lang, Fodé Bangaly Sako, Fodé Amara Traoré, Eudoxie Koumbem, Halidou Tinto, Adama Sanou, Apoline Sondo, Flavien Kaboré, Joseph Donamou, Jean-Paul-Yassa Guilavogui, Fanny Velardo, Brice Bicaba, Olivier Marcy, Augustin Augier, Sani Sayadi, Armel Poda, Sakoba Keita, Xavier Anglaret, Denis Malvy, COVISTA group

Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa (Journal Article)

In: Int. J. Infect. Dis., vol. 108, pp. 45–52, 2021, ISSN: 1878-3511 1201-9712, (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. PMID: 34000419 PMCID: PMC8120805).

(Abstract | Links | BibTeX | Altmetric | Tags: Adult, Aged, Burkina Faso/epidemiology, Comorbidities, COVID-19, Female, Hospitalization, Humans, Male, Mortality, Prospective Studies, Referral and Consultation, SARS-Cov-2, sub-Saharan Africa)

Nutritional status in young children prior to the malaria  transmission season in Burkina Faso and Mali, and its impact on  the incidence of clinical malaria

Mariken Wit, Matthew Cairns, Yves Daniel Compaoré, Issaka Sagara, Irene Kuepfer, Issaka Zongo, Amadou Barry, Modibo Diarra, Amadou Tapily, Samba Coumare, Ismaila Thera, Frederic Nikiema, R Serge Yerbanga, Rosemonde M Guissou, Halidou Tinto, Alassane Dicko, Daniel Chandramohan, Brian Greenwood, Jean Bosco Ouedraogo

Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria (Journal Article)

In: Malar. J., vol. 20, no. 1, pp. 274, 2021, ISSN: 1475-2875, (PMID: 34158054 PMCID: PMC8220741).

(Abstract | Links | BibTeX | Altmetric | Tags: Acute malnutrition, Antimalarials/administration & dosage, Azithromycin/administration & dosage, Burkina Faso, Burkina Faso/epidemiology, Child, Chronic malnutrition, Female, Humans, Incidence, Infant, Malaria, Malaria/epidemiology/transmission, Male, Nutritional Status, Preschool, seasonal malaria chemoprevention, Seasons)

Polymorphisms in Plasmodium falciparum parasites and mutations in the resistance genes Pfcrt and Pfmdr1 in Nanoro area, Burkina Faso.

Paul Sondo, Biebo Bihoun, Bérenger Kabore, Marc Christian Tahita, Karim Derra, Toussaint Rouamba, Seydou Nakanabo Diallo, Adama Kazienga, Hamidou Ilboudo, Innocent Valea, Zekiba Tarnagda, Hermann Sorgho, Thierry Lefevre, Halidou Tinto

Polymorphisms in Plasmodium falciparum parasites and mutations in the resistance genes Pfcrt and Pfmdr1 in Nanoro area, Burkina Faso. (Journal Article)

In: Pan Afr. Med. J., vol. 39, pp. 118, 2021, ISSN: 1937-8688, (Copyright: Paul Sondo et al. PMID: 34512854 PMCID: PMC8396377).

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarials/pharmacology, Burkina Faso, Drug Resistance, Falciparum/drug therapy/parasitology, GeneticRestriction Fragment Length, Genotype, Humans, Malaria, Membrane Transport Proteins/genetics, msp1, msp2, Multidrug Resistance-Associated Proteins/genetics, Mutation, Pfcrt, Pfmdr1, Plasmodium falciparum, Plasmodium falciparum/drug effects/genetics/isolation & purification, Polymerase Chain Reaction, Polymorphism, Protozoan Proteins/genetics)

Altered ex-vivo cytokine responses in children with asymptomatic  Plasmodium falciparum infection in Burkina Faso: An additional  argument to treat asymptomatic malaria?

Annelies Post, Berenger Kaboré, Mike Berendsen, Salou Diallo, Ousmane Traore, Rob J W Arts, Mihai G Netea, Leo A B Joosten, Halidou Tinto, Jan Jacobs, Quirijn Mast, André Ven

Altered ex-vivo cytokine responses in children with asymptomatic Plasmodium falciparum infection in Burkina Faso: An additional argument to treat asymptomatic malaria? (Journal Article)

In: Front. Immunol., vol. 12, pp. 614817, 2021, ISSN: 1664-3224, (Copyright © 2021 Post, Kaboré, Berendsen, Diallo, Traore, Arts, Netea, Joosten, Tinto, Jacobs, de Mast and van der Ven. PMID: 34177883 PMCID: PMC8220162).

(Abstract | Links | BibTeX | Altmetric | Tags: Asymptomatic Diseases, asymptomatic malaria, bacteraemia, Bacteremia, bloodstream infection, Burkina Faso/epidemiology, Cells, Child, Cultured, Cytokines/metabolism, Endemic Diseases, Female, Humans, Infant, iNTS, Lipopolysaccharides/immunology, Malaria/epidemiology/immunology, Male, Parasite Load, Plasmodium falciparum/physiology, Preschool, Salmonella)

Assessment of a combined strategy of seasonal malaria  chemoprevention and supplementation with vitamin A, zinc and  Plumpy'Doz™ to prevent malaria and malnutrition in children  under 5 years old in Burkina Faso: a randomized open-label trial  (SMC-NUT)

Paul Sondo, Marc Christian Tahita, Toussaint Rouamba, Karim Derra, Bérenger Kaboré, Cheick Sa"id Compaoré, Florence Ouédraogo, Eli Rouamba, Hamidou Ilboudo, Estelle A"issa Bambara, Macaire Nana, Edmond Yabré Sawadogo, Hermann Sorgho, Athanase Mwinessobaonfou Somé, Innocent Valéa, Prabin Dahal, Maminata Traoré/Coulibaly, Halidou Tinto

Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy’Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT) (Journal Article)

In: Trials, vol. 22, no. 1, pp. 360, 2021, ISSN: 1745-6215, (PMID: 34030705 PMCID: PMC8142067).

(Abstract | Links | BibTeX | Altmetric | Tags: Antimalarials/adverse effects, Burkina Faso/epidemiology, Chemoprevention, Child, Child Nutrition Disorders, Dietary Supplements, Humans, Infant, Malaria, Malaria/diagnosis/epidemiology/prevention & control, Malnutrition, Malnutrition/diagnosis/drug therapy/prevention & control, Pharmaceutical Preparations, Plumpy’Doz™, Preschool, Randomized controlled trial, Seasonal chemoprevention, Seasons, Vitamin A, Vitamin A/adverse effects, Zinc)

Socioeconomic inequalities in curative healthcare-seeking for  children under five before and after the free healthcare  initiative in Sierra Leone: analysis of population-based survey  data

Joel D Bognini, Sekou Samadoulougou, Mady Ouedraogo, Tiga David Kangoye, Carine Van Malderen, Halidou Tinto, Fati Kirakoya-Samadoulougou

Socioeconomic inequalities in curative healthcare-seeking for children under five before and after the free healthcare initiative in Sierra Leone: analysis of population-based survey data (Journal Article)

In: Int. J. Equity Health, vol. 20, no. 1, pp. 124, 2021, ISSN: 1475-9276, (PMID: 34020665 PMCID: PMC8140517).

(Abstract | Links | BibTeX | Altmetric | Tags: Adolescent, Adult, Child, Children under five, Delivery of Health Care/economics, Female, Health Care Surveys, Healthcare Disparities/economics/statistics & numerical data, Healthcare utilization, Humans, Infant, Male, Parents/psychology, Patient Acceptance of Health Care/statistics & numerical data, Preschool, Sierra Leone, Socioeconomic Factors, Young Adult)

A randomized, double-blind, phase 2b study to investigate the  efficacy, safety, tolerability and pharmacokinetics of a  single-dose regimen of ferroquine with artefenomel in adults and  children with uncomplicated Plasmodium falciparum malaria

Yeka Adoke, Rella Zoleko-Manego, Serge Ouoba, Alfred B Tiono, Grace Kaguthi, Juv^encio Eduardo Bonzela, Tran Thanh Duong, Alain Nahum, Marielle Bouyou-Akotet, Bernhards Ogutu, Alphonse Ouedraogo, Fiona Macintyre, Andreas Jessel, Bart Laurijssens, Mohammed H Cherkaoui-Rbati, Cathy Cantalloube, Anne Claire Marrast, Rapha"el Bejuit, David White, Timothy N C Wells, Florian Wartha, Didier Leroy, Afizi Kibuuka, Ghyslain Mombo-Ngoma, Daouda Ouattara, Ir`ene Mugenya, Bui Quang Phuc, Francis Bohissou, Denise P Mawili-Mboumba, Fredrick Olewe, Issiaka Soulama, Halidou Tinto, FALCI Study Group

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria (Journal Article)

In: Malar. J., vol. 20, no. 1, pp. 222, 2021, ISSN: 1475-2875, (PMID: 34011358 PMCID: PMC8135182).

(Abstract | Links | BibTeX | Altmetric | Tags: Adamantane/administration & dosage/analogs & derivatives, Adolescent, Adult, Aged, Aminoquinolines/administration & dosage, Benin, Burkina Faso, C580Y, Child, Combination treatment, Double-Blind Method, Drug Combinations, Exposure–response, Falciparum/prevention & control, Female, Ferroquine, Ferrous Compounds/administration & dosage, Gabon, Humans, Infant, Kelch-13 mutation, Kenya, Malaria, Male, Metallocenes/administration & dosage, Middle Aged, Mozambique, Parasite clearance, Peroxides/administration & dosage, Pharmacokinetics/pharmacodynamics, Plasmodium falciparum/drug effects, Preschool, resistance, Uganda, Vietnam, Vomiting, Young Adult)

33 entries « 1 of 2 »