 | Massa Dit Achille Bonko, Marc Christian Tahita, Francois Kiemde, Palpouguini Lompo, Sibidou Yougbaré, Athanase M Some, Halidou Tinto, Petra F Mens, Sandra Menting, Henk D F H Schallig Antibiotic susceptibility profile of bacterial isolates from febrile children under 5 years of age in Nanoro, Burkina Faso (Journal Article) In: Trop. Med. Int. Health, vol. 26, no. 10, pp. 1220–1230, 2021, ISSN: 1365-3156 1360-2276, (© 2021 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd.
Place: England
PMID: 34185935). @article{Bonko2021-en,
title = {Antibiotic susceptibility profile of bacterial isolates from febrile children under 5 years of age in Nanoro, Burkina Faso},
author = {Massa Dit Achille Bonko and Marc Christian Tahita and Francois Kiemde and Palpouguini Lompo and Sibidou Yougbar\'{e} and Athanase M Some and Halidou Tinto and Petra F Mens and Sandra Menting and Henk D F H Schallig},
doi = {10.1111/tmi.13644},
issn = {1365-3156 1360-2276},
year = {2021},
date = {2021-10-01},
urldate = {2021-10-01},
journal = {Trop. Med. Int. Health},
volume = {26},
number = {10},
pages = {1220--1230},
publisher = {Wiley},
abstract = {OBJECTIVES: Antibiotics efficacy is severely threatened due to
emerging resistance worldwide, but there is a paucity of
antibiotics efficacy data for the West African region in
general. Therefore, this study aimed to determine the antibiotic
susceptibility profile of bacterial isolated from febrile
children under 5 years of age in Nanoro (Burkina Faso). METHODS:
Blood, stool and urine samples were collected from 1099 febrile
children attending peripheral health facilities and the referral
hospital in Nanoro Health district. Bacterial isolates from
these samples were assessed for their susceptibility against
commonly used antibiotics by Kirby-Bauer method. RESULTS: In
total, 141 bacterial isolates were recovered from 127 febrile
children of which 65 from blood, 65 from stool and 11 from
urine. Salmonella isolates were most frequently isolated and
found to be highly resistant to ampicillin (70%; 56/80) and
trimethoprim-sulphamethoxazole (65%; 52/80). Escherichia coli
isolates showed a high resistance rate to
trimethoprim-sulphamethoxazole (100%), ampicillin (100%),
ciprofloxacin (71.4%; 10/14), amoxicillin-clavulanate (64.3%;
9/14), ceftriaxone (64.3%; 9/14) and gentamycin (50%; 7/14).
Moreover, half of the E. coli isolates produced \ss-lactamase
suggesting multi-drug resistance against $beta$-lactam as well
as non-$beta$-lactam antibiotics. Multi-drug resistance was
observed in 54.6% (59/108) of the isolates, mainly
Gram-negative bacteria. CONCLUSIONS: This study showed high
resistance rates to common antibiotics used to treat bacterial
infections in Nanoro. The work prompts the need to expand
antibiotic resistance surveillance studies in Burkina Faso.},
note = {© 2021 The Authors Tropical Medicine \& International Health Published by John Wiley \& Sons Ltd.
Place: England
PMID: 34185935},
keywords = {antibiotic resistance, bacteria, febrile children},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: Antibiotics efficacy is severely threatened due to
emerging resistance worldwide, but there is a paucity of
antibiotics efficacy data for the West African region in
general. Therefore, this study aimed to determine the antibiotic
susceptibility profile of bacterial isolated from febrile
children under 5 years of age in Nanoro (Burkina Faso). METHODS:
Blood, stool and urine samples were collected from 1099 febrile
children attending peripheral health facilities and the referral
hospital in Nanoro Health district. Bacterial isolates from
these samples were assessed for their susceptibility against
commonly used antibiotics by Kirby-Bauer method. RESULTS: In
total, 141 bacterial isolates were recovered from 127 febrile
children of which 65 from blood, 65 from stool and 11 from
urine. Salmonella isolates were most frequently isolated and
found to be highly resistant to ampicillin (70%; 56/80) and
trimethoprim-sulphamethoxazole (65%; 52/80). Escherichia coli
isolates showed a high resistance rate to
trimethoprim-sulphamethoxazole (100%), ampicillin (100%),
ciprofloxacin (71.4%; 10/14), amoxicillin-clavulanate (64.3%;
9/14), ceftriaxone (64.3%; 9/14) and gentamycin (50%; 7/14).
Moreover, half of the E. coli isolates produced ß-lactamase
suggesting multi-drug resistance against $beta$-lactam as well
as non-$beta$-lactam antibiotics. Multi-drug resistance was
observed in 54.6% (59/108) of the isolates, mainly
Gram-negative bacteria. CONCLUSIONS: This study showed high
resistance rates to common antibiotics used to treat bacterial
infections in Nanoro. The work prompts the need to expand
antibiotic resistance surveillance studies in Burkina Faso. |
