Publications

@article{Lingani2021-is,

title = {Malaria and curable sexually transmitted and reproductive tract  coinfection among pregnant women in rural Burkina Faso},

author = {Moussa Lingani and Serge H Zango and Innocent Val\'{e}a and Massa Dit A Bonko and S\'{e}kou O Samadoulougou and Toussaint Rouamba and Marc C Tahita and Ma"imouna Sanou and Annie Robert and Halidou Tinto and Philippe Donnen and Mich`ele Dramaix},

doi = {10.1186/s41182-021-00381-5},

issn = {1348-8945 1349-4147},

year  = {2021},

date = {2021-11-01},

urldate = {2021-11-01},

journal = {Trop. Med. Health},

volume = {49},

number = {1},

pages = {90},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Malaria and sexually transmitted/reproductive tract 

 infections (STI/RTI) are leading and preventable causes of low 

 birthweight in sub-Saharan Africa. Reducing their impact on 

 pregnancy outcomes requires efficient interventions that can be 

 easily integrated into the antenatal care package. The paucity 

 of data on malaria and STI/RTI coinfection, however, limits 

 efforts to control these infections. This study aimed to 

 determine the prevalence and associated factors of malaria and 

 STI/RTI coinfection among pregnant women in rural Burkina Faso. 

 METHODS: A cross-sectional survey was conducted among 402 

 pregnant women attending antenatal clinics at the Yako health 

 district. Sociodemographic and behavioral data were collected, 

 and pregnant women were tested for peripheral malaria by 

 microscopy. Hemoglobin levels were also measured by 

 spectrophotometry and curable bacterial STI/RTI were tested on 

 cervico-vaginal swabs using rapid diagnostic test for chlamydia 

 and syphilis, and Gram staining for bacterial vaginosis. A 

 multivariate logistic regression model was used to assess the 

 association of malaria and STI/RTI coinfection with the 

 characteristics of included pregnant women. RESULTS: The 

 prevalence of malaria and at least one STI/RTI coinfection was 

 12.9% (95% confidence interval, CI: [9.8-16.7]), malaria and 

 bacterial vaginosis coinfection was 12.2% (95% CI: 

 [9.3-15.9]), malaria and chlamydial coinfection was 1.6% (95% 

 CI: [0.6-3.8]). No coinfection was reported for malaria and 

 syphilis. The individual prevalence was 17.2%, 7.2%, 0.6%, 

 67.7% and 73.3%, respectively, for malaria infection, 

 chlamydia, syphilis, bacterial vaginosis and STI/RTI 

 combination. Only 10% of coinfections were symptomatic, and 

 thus, 90% of women with coinfection would have been missed by 

 the symptoms-based diagnostic approach. In the multivariate analysis, the first pregnancy (aOR = 2.4 [95% CI: 1.2-4.7]) was 

 the only factor significantly associated with malaria and 

 STI/RTI coinfection. Clinical symptoms were not associated with 

 malaria and STI/RTI coinfection. CONCLUSION: The prevalence of 

 malaria and curable STI/RTI coinfection was high among pregnant 

 women. The poor performance of the clinical symptoms to predict 

 coinfection suggests that alternative interventions are needed.},

note = {© 2021. The Author(s).

PMID: 34736524 

PMCID: PMC8567650},

keywords = {Bacterial vaginosis, Burkina Faso, Chlamydia, Coinfection, Malaria, Pregnancy, Syphilis},

pubstate = {published},

tppubtype = {article}

}

@article{Zango2021-ti,

title = {Association of malaria and curable sexually transmitted  infections with pregnancy outcomes in rural Burkina Faso},

author = {Serge Henri Zango and Moussa Lingani and Innocent Valea and Ouindpanga Sekou Samadoulougou and Biebo Bihoun and Diagniagou Lankoande and Phillipe Donnen and Michele Dramaix and Halidou Tinto and Annie Robert},

doi = {10.1186/s12884-021-04205-6},

issn = {1471-2393},

year  = {2021},

date = {2021-10-27},

urldate = {2021-10-27},

journal = {BMC Pregnancy Childbirth},

volume = {21},

number = {1},

pages = {722},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Malaria and curable sexually transmitted infections 

 (STIs) are severe infections associated with poor pregnancy 

 outcomes in sub-Saharan countries. These infections are 

 responsible for low birth weight, preterm birth, and 

 miscarriage. In Burkina Faso, many interventions recommended by 

 the World Health Organization were implemented to control the 

 impact of these infections. After decades of intervention, we 

 assessed the impact of these infections on pregnancy outcomes in 

 rural setting of Burkina Faso. METHODS: Antenatal care and 

 delivery data of pregnant women attending health facilities in 

 2016 and 2017 were collected in two rural districts namely 

 Nanoro and Yako, in Burkina Faso. Regression models with 

 likelihood ratio test were used to assess the association 

 between infections and pregnancy outcomes. RESULTS: During the 

 two years, 31639 pregnant women received antenatal care. Malaria 

 without STI, STI without malaria, and their coinfections were 

 reported for 7359 (23.3%), 881 (2.8 %), and 388 (1.2%) women, 

 respectively. Low birth weight, miscarriage, and stillbirth were 

 observed in 2754 (10.5 %), 547 (2.0 %), and 373 (1.3 %) 

 women, respectively. Our data did not show an association 

 between low birth weight and malaria [Adjusted OR: 0.91 (0.78 - 

 1.07)], STIs [Adjusted OR: 0.74 (0.51 - 1.07)] and coinfection 

 [Adjusted OR: 1.15 (0.75 - 1.78)]. Low birth weight was strongly 

 associated with primigravidae [Adjusted OR: 3.53 (3.12 - 4.00)]. 

 Both miscarriage and stillbirth were associated with malaria 

 [Adjusted OR: 1.31 (1.07 - 1.59)], curable STI [Adjusted OR: 

 1.65 (1.06 - 2.59)], and coinfection [Adjusted OR: 2.00 (1.13 - 

 3.52)]. CONCLUSION: Poor pregnancy outcomes remained frequent in 

 rural Burkina Faso. Malaria, curable STIs, and their 

 coinfections were associated with both miscarriage and 

 stillbirth in rural Burkina. More effort should be done to 

 reduce the proportion of pregnancies lost associated with these 

 curable infections by targeting interventions in primigravidae 

 women.},

note = {© 2021. The Author(s).

PMID: 34706705 

PMCID: PMC8549350},

keywords = {Coinfection, Impact, Malaria, Outcome, Pregnancy, STI},

pubstate = {published},

tppubtype = {article}

}