 | Palwende Romuald Boua, Jean-Tristan Brandenburg, Ananyo Choudhury, Hermann Sorgho, Engelbert A. Nonterah, Godfred Agongo, Gershim Asiki, Lisa Micklesfield, Solomon Choma, Francesc Xavier Gómez-Olivé, Scott Hazelhurst, Halidou Tinto, Nigel J. Crowther, Christopher G. Mathew, Michèle Ramsay Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans. (Journal Article) In: Nature communications, vol. 13, iss. 1, pp. 855, 2022. @article{Boua2022,
title = {Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.},
author = {Palwende Romuald Boua and Jean-Tristan Brandenburg and Ananyo Choudhury and Hermann Sorgho and Engelbert A. Nonterah and Godfred Agongo and Gershim Asiki and Lisa Micklesfield and Solomon Choma and Francesc Xavier G\'{o}mez-Oliv\'{e} and Scott Hazelhurst and Halidou Tinto and Nigel J. Crowther and Christopher G. Mathew and Mich\`{e}le Ramsay},
doi = {10.1038/s41467-022-28276-x},
year = {2022},
date = {2022-02-01},
urldate = {2022-02-01},
journal = {Nature communications},
volume = {13},
issue = {1},
pages = {855},
abstract = {Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies.},
keywords = {Adult, Africa South of the Sahara, Atherosclerosis/*genetics/*pathology, Autoantigens/genetics, Cardiovascular Diseases/genetics, Carotid Intima-Media Thickness/*statistics \& numerical data, Endocrine-Gland-Derived/genetics, Female, Gastrointestinal Hormones/genetics, Genetic Predisposition to Disease/*genetics, Genome/genetics, Histones/genetics, Humans, Male, Middle Aged, Polymorphism, Ribonucleoproteins/genetics, Sex Factors, Single Nucleotide/genetics, Sorting Nexins/genetics, Vascular Endothelial Growth Factor},
pubstate = {published},
tppubtype = {article}
}
Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies. |
