 | Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gómez-Olivé, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, Scott Hazelhurst, Michèle Ramsay Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits. (Journal Article) In: Nature communications, vol. 13, iss. 1, pp. 2578, 2022. @article{nokey,
title = {Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.},
author = {Ananyo Choudhury and Jean-Tristan Brandenburg and Tinashe Chikowore and Dhriti Sengupta and Palwende Romuald Boua and Nigel J. Crowther and Godfred Agongo and Gershim Asiki and F. Xavier G\'{o}mez-Oliv\'{e} and Isaac Kisiangani and Eric Maimela and Matshane Masemola-Maphutha and Lisa K. Micklesfield and Engelbert A. Nonterah and Shane A. Norris and Hermann Sorgho and Halidou Tinto and Stephen Tollman and Sarah E. Graham and Cristen J. Willer and Scott Hazelhurst and Mich\`{e}le Ramsay},
doi = {10.1038/s41467-022-30098-w},
year = {2022},
date = {2022-05-01},
urldate = {2022-05-01},
journal = {Nature communications},
volume = {13},
issue = {1},
pages = {2578},
abstract = {Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in the GATB region (P-value=1.56 × 10(-8)). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with the GATB/FHIP1A region and identifies a novel triglyceride association signal close to the FHIT gene (P-value =2.66 × 10(-8)). Our data enable fine-mapping of several well-known lipid-trait loci including LDLR, PMFBP1 and LPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data.},
keywords = {*Genome-Wide Association Study, Africa South of the Sahara, Cholesterol, Cross-Sectional Studies, Humans, LDL/genetics},
pubstate = {published},
tppubtype = {article}
}
Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in the GATB region (P-value=1.56 × 10(-8)). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with the GATB/FHIP1A region and identifies a novel triglyceride association signal close to the FHIT gene (P-value =2.66 × 10(-8)). Our data enable fine-mapping of several well-known lipid-trait loci including LDLR, PMFBP1 and LPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data. |
