| Charlie Franck Alfred Compaoré, Jacques Kaboré, Hamidou Ilboudo, Lian Francesca Thomas, Laura Cristina Falzon, Mohamed Bamba, Hassane Sakande, Minayégninrin Koné, Dramane Kaba, Clarisse Bougouma, Ilboudo Adama, Ouedraogo Amathe, Adrien Marie Gaston Belem, Eric Maurice Fèvre, Philippe Büscher, Veerle Lejon, Vincent Jamonneau Journal Article) In: Parasite, vol. 29, pp. 25, 2022, ISSN: 1776-1042. @article{nokey,
title = {Monitoring the elimination of \textit{gambiense} human African trypanosomiasis in the historical focus of Bati\'{e}, South\textendashWest Burkina Faso},
author = {Charlie Franck Alfred Compaor\'{e} and Jacques Kabor\'{e} and Hamidou Ilboudo and Lian Francesca Thomas and Laura Cristina Falzon and Mohamed Bamba and Hassane Sakande and Minay\'{e}gninrin Kon\'{e} and Dramane Kaba and Clarisse Bougouma and Ilboudo Adama and Ouedraogo Amathe and Adrien Marie Gaston Belem and Eric Maurice F\`{e}vre and Philippe B\"{u}scher and Veerle Lejon and Vincent Jamonneau},
url = {https://www.parasite-journal.org/10.1051/parasite/2022024},
doi = {10.1051/parasite/2022024},
issn = {1776-1042},
year = {2022},
date = {2022-01-01},
journal = {Parasite},
volume = {29},
pages = {25},
abstract = {\<p\> The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of \<italic\>Trypanosoma brucei gambiense\</italic\> HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Bati\'{e}, South\textendashWest Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/ \<italic\>T. b. gambiense\</italic\> and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero- \<italic\>K\</italic\> -Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/ \<italic\>T. b. gambiense\</italic\> and trypanolysis was 99% (98\textendash99%) and 100% (99\textendash100%), respectively. Our results suggest that \<italic\>T. b. gambiense\</italic\> is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso. \</p\>},
keywords = {Burkina Faso, Diagnosis, Dried blood spot, Elimination, Human African trypanosomiasis, Rapid diagnostic test, Specificity, Trypanosoma brucei gambiense},
pubstate = {published},
tppubtype = {article}
}
<p> The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of <italic>Trypanosoma brucei gambiense</italic> HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Batié, South–West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/ <italic>T. b. gambiense</italic> and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero- <italic>K</italic> -Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/ <italic>T. b. gambiense</italic> and trypanolysis was 99% (98–99%) and 100% (99–100%), respectively. Our results suggest that <italic>T. b. gambiense</italic> is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso. </p> |
