 | Martin Bienvenu Somda, Martial Kassi N’Djetchi, Jacques Kaboré, Hamidou Ilboudo, Emilie Dama, Soudah Boma, Fabrice Courtin, Anne Poinsignon, Zakaria Bengaly, Franck Remoué, Adrien Marie Gaston Belem, Bruno Bucheton, Vincent Jamonneau, Mathurin Koffi Evaluation of antibody responses to tsetse fly saliva in domestic animals in the sleeping sickness endemic foci of Bonon and Sinfra, Côte d’Ivoire (Journal Article) In: Veterinary Parasitology: Regional Studies and Reports, vol. 34, iss. 2, pp. 100773, 2022, ISSN: 24059390. @article{Somda2022,
title = {Evaluation of antibody responses to tsetse fly saliva in domestic animals in the sleeping sickness endemic foci of Bonon and Sinfra, C\^{o}te d'Ivoire},
author = {Martin Bienvenu Somda and Martial Kassi N'Djetchi and Jacques Kabor\'{e} and Hamidou Ilboudo and Emilie Dama and Soudah Boma and Fabrice Courtin and Anne Poinsignon and Zakaria Bengaly and Franck Remou\'{e} and Adrien Marie Gaston Belem and Bruno Bucheton and Vincent Jamonneau and Mathurin Koffi},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2405939022000892},
doi = {10.1016/j.vprsr.2022.100773},
issn = {24059390},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
journal = {Veterinary Parasitology: Regional Studies and Reports},
volume = {34},
issue = {2},
pages = {100773},
address = {Switzerland},
abstract = {After intensive control efforts, human African trypanosomiasis (HAT) was declared eliminated in C\^{o}te d'Ivoire as a public health problem in December 2020 and the current objective is to achieve the interruption of the transmission (zero cases). Reaching this objective could be hindered by the existence of an animal reservoir of Trypanosoma (T.) brucei (b.) gambiense. In the framework of a study led in 2013 to assess the role of domestic animals in the epidemiology of HAT in the two last active foci from C\^{o}te d'Ivoire (Bonon and Sinfra), plasmas were sampled from four species of domestic animals for parasitological (microscopic examination by the buffy coat technique (BCT)), serological (immune trypanolysis (TL)) and molecular (specific PCR: TBR for T. brucei s.l., TCF for T. congolense forest type, TVW for T. vivax and PCR for T. b. gambiense) testing. In order to improve the understanding of the involvement/role of these animals in the transmission of T. b. gambiense, we have quantified in this study the IgG response to whole saliva extracts of Glossina palpalis gambiensis in order to perform an association analysis between anti-saliva responses and the positivity of diagnostic tests. Cattle and pigs had significantly higher rates of anti-tsetse saliva responses compared to goats and sheep (p \< 0.01). In addition, the anti-tsetse saliva responses were strongly associated with the parasitology (BCT+), serology (TL+) and PCR (TBR+ and TCF+) results (p \< 0.001). These associations indicate a high level of contacts between the positive/infected animals and tsetse flies. Our findings suggest that protecting cattle and pigs against tsetse bites could have a significant impact in reducing transmission of both animal and human trypanosome species, and advocates for a "One health" approach to better control African trypanosomosis in C\^{o}te d'Ivoire.},
keywords = {Animal reservoirs, Biomarker of exposure, C\^{o}te d'Ivoire, Trypanosoma brucei gambiense, Tsetse fly},
pubstate = {published},
tppubtype = {article}
}
After intensive control efforts, human African trypanosomiasis (HAT) was declared eliminated in Côte d’Ivoire as a public health problem in December 2020 and the current objective is to achieve the interruption of the transmission (zero cases). Reaching this objective could be hindered by the existence of an animal reservoir of Trypanosoma (T.) brucei (b.) gambiense. In the framework of a study led in 2013 to assess the role of domestic animals in the epidemiology of HAT in the two last active foci from Côte d’Ivoire (Bonon and Sinfra), plasmas were sampled from four species of domestic animals for parasitological (microscopic examination by the buffy coat technique (BCT)), serological (immune trypanolysis (TL)) and molecular (specific PCR: TBR for T. brucei s.l., TCF for T. congolense forest type, TVW for T. vivax and PCR for T. b. gambiense) testing. In order to improve the understanding of the involvement/role of these animals in the transmission of T. b. gambiense, we have quantified in this study the IgG response to whole saliva extracts of Glossina palpalis gambiensis in order to perform an association analysis between anti-saliva responses and the positivity of diagnostic tests. Cattle and pigs had significantly higher rates of anti-tsetse saliva responses compared to goats and sheep (p < 0.01). In addition, the anti-tsetse saliva responses were strongly associated with the parasitology (BCT+), serology (TL+) and PCR (TBR+ and TCF+) results (p < 0.001). These associations indicate a high level of contacts between the positive/infected animals and tsetse flies. Our findings suggest that protecting cattle and pigs against tsetse bites could have a significant impact in reducing transmission of both animal and human trypanosome species, and advocates for a “One health” approach to better control African trypanosomosis in Côte d’Ivoire. |
