Publications

@article{Neyer2023,

title = {Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study},

author = {Peter J. Neyer and B\'{e}renger Kabor\'{e} and Christos T. Nakas and Britta Hartmann and Annelies Post and Salou Diallo and Halidou Tinto and Angelika Hammerer-Lercher and Carlo R. Largiad\`{e}r and Andre J. Ven and Andreas R. Huber},

url = {https://pubmed.ncbi.nlm.nih.gov/37658365/},

doi = {10.1186/S12936-023-04686-0},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: Asymptomatic Plasmodium falciparum parasitaemia forms a reservoir for the transmission of malaria disease in West Africa. Certain haemoglobin variants are known to protect against severe malaria infection. However, data on the potential roles of haemoglobin variants and nongenetic factors in asymptomatic malaria infection is scarce and controversial. Therefore, this study investigated the associations of iron homeostasis, inflammation, nutrition, and haemoglobin mutations with parasitaemia in an asymptomatic cohort from a P. falciparum-endemic region during the high transmission season. Methods: A sub-study population of 688 asymptomatic individuals (predominantly children and adolescents under 15 years},

keywords = {Adolescent, Andreas R Huber, Asymptomatic Infections / epidemiology, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Child, doi:10.1186/s12936-023-04686-0, Falciparum* / epidemiology, hemoglobin, Hepcidins*, Humans, Malaria, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peter J Neyer, Plasmodium falciparum / genetics, PMC10474782, pmid:37658365, PubMed Abstract, Sickle},

pubstate = {published},

tppubtype = {article}

}

@article{Starck2022,

title = {The effect of malaria on childhood anemia in a quasi-experimental study of 7,384 twins from 23 Sub-Saharan African countries},

author = {Tim Starck and Peter Dambach and Toussaint Rouamba and Halidou Tinto and Faith Osier and Catherine E. Oldenburg and Maya Adam and Till B\"{a}rnighausen and Thomas Jaenisch and Caroline A. Bulstra},

url = {https://www.frontiersin.org/articles/10.3389/fpubh.2022.1009865/full},

doi = {10.3389/fpubh.2022.1009865},

issn = {2296-2565},

year  = {2022},

date = {2022-01-01},

journal = {Frontiers in Public Health},

volume = {10},

pages = {1009865},

abstract = {BACKGROUND Young children in Sub-Saharan Africa (SSA), particularly those from resource-limited settings, are heavily burdened by anemia and malaria. While malaria infected children frequently become anemic (hemoglobin \< 110 g/L), anemia is a strongly multifactorial disease with many other risk factors than malaria. Due to the complex and often overlapping contributors to anemia, it remains challenging to isolate the true impact of malaria on population level hemoglobin concentrations. METHODS We quantified the malaria-induced effect on hemoglobin levels in children under 5 years of age, leveraging data from 7,384 twins and other multiples, aged 6 to 59 months, from 57 nationally representative Demographic and Health Surveys (DHSs) from 23 SSA countries from 2006 to 2019. The quasi-experimental twin fixed-effect design let us minimize the impact of potential confounders that do not vary between twins. RESULTS Our analyses of twins revealed a malaria-induced hemoglobin decrease in infected twins of 9 g/L (95% CI -10; -7, p\<0.001). The relative risk of severe anemia was higher (RR = 3.01, 95% CI 1.79; 5.1, p\<0.001) among malaria positive children, compared to malaria negative children. Conversely, malaria positive children are only half as likely to be non-anemic (RR = 0.51, 95% CI 0.43; 0.61, p\<0.001). CONCLUSION Even after rigorous control for confounding through a twin fixed-effects study design, malaria substantially decreased hemoglobin levels among SSA twins, rendering them much more susceptible to severe anemia. This effect reflects the population-level effect of malaria on anemia.},

keywords = {anemia-etiology, DHS, fixed-effect, hemoglobin, Malaria, multiples, Sub-Sahara Africa, twins},

pubstate = {published},

tppubtype = {article}

}