Publications

@article{Lompo2023,

title = {Growth of Gram-Negative Bacteria in Antiseptics, Disinfectants and Hand Hygiene Products in Two Tertiary Care Hospitals in West Africa\textemdashA Cross-Sectional Survey},

author = {Palpouguini Lompo and Anne Sophie Heroes and Esenam Agbobli and Adama Kazienga and Marjan Peeters and Halidou Tinto and Katrien Lagrou and Lassana Sangar\'{e} and Dissou Affolabi and Jan Jacobs},

url = {https://www.mdpi.com/2076-0817/12/7/917/htm https://www.mdpi.com/2076-0817/12/7/917},

doi = {10.3390/PATHOGENS12070917/S1},

issn = {20760817},

year  = {2023},

date = {2023-01-01},

journal = {Pathogens},

volume = {12},

issue = {7},

pages = {917},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

abstract = {Antiseptics, disinfectants, and hand hygiene products can act as reservoirs of Gram-negative bacteria causing healthcare-associated infections. This problem is rarely documented in low- and middle-income countries, particularly in sub-Saharan Africa. In a cross-sectional survey, we assessed the bacterial contamination of antiseptics, disinfectants, and hand hygiene products in two university hospitals in Burkina Faso and Benin. During ward visits and staff interviews, in-use products were cultured for the presence of Gram-negative bacteria. The growth of Gram-negative bacteria was absent or rare in alcohol-based products, povidone iodine, and Dakin solution. Contamination was highest (73.9% (51/69)) for liquid soap products (versus antiseptic/disinfectants (4.5%, 7/157) (p \< 0.0001)), mostly used in high-risk areas and associated with high total bacterial counts (\>10,000 colony-forming units/mL). Contaminating flora (105 isolates) included Enterobacterales and the Vibrio non-cholerae/Aeromonas group (17.1%) and non-fermentative Gram-negative rods (82.8%). Multidrug resistance was present among 9/16 Enterobacterales (Klebsiella and Enterobacter spp.) and 3/12 Acinetobacter spp., including carbapenem resistance (Acinetobacter baumannii: NDM, Pseudomonas stutzeri: VIM). The risk factors for contamination included the type of product (cleaning grade and in-house prepared liquid soap), use of recycled disposable containers and soft drink bottles, absence of labeling, topping-up of containers, dilution with tap water (pharmacy and ward), and poor-quality management (procurement, stock management, expiry dates, and period after opening).},

keywords = {antiseptics, bacteria, cross-sectional, disinfectants, Gram-negative, hand hygiene, healthcare-associated infections, low-and middle-income countries, resistance, West Africa},

pubstate = {published},

tppubtype = {article}

}

@article{Sawadogo2022,

title = {Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa},

author = {Yacouba Sawadogo and Lokman Galal and Essia Belarbi and Ars\`{e}ne Zongo and Grit Schubert and Fabian Leendertz and Abdoulie Kanteh and Abdul Karim Sesay and Annette Erhart and Anne-Laure Ba\~{n}uls and Z\'{e}kiba Tarnagda and Sylvain Godreuil and Halidou Tinto and Abdoul-Salam Ouedraogo},

url = {https://www.mdpi.com/1999-4915/14/12/2788},

doi = {10.3390/v14122788},

issn = {1999-4915},

year  = {2022},

date = {2022-01-01},

journal = {Viruses},

volume = {14},

issue = {12},

pages = {2788},

abstract = {\<p\>Background: After its initial detection in Wuhan, China, in December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of SARS-CoV-2 in Burkina Faso. Methods: Three hundred and seventy-seven SARS-CoV-2 genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score \< 35) collected between 5 May 2020, and 31 January 2022 were analyzed. Genomic sequences were assigned to phylogenetic clades using NextClade and to Pango lineages using pangolin. Phylogenetic and phylogeographic analyses were performed to determine the geographical sources and time of virus introduction in Burkina Faso. Results: The analyzed SARS-CoV-2 genomes can be assigned to 10 phylogenetic clades and 27 Pango lineages already described worldwide. Our analyses revealed the important role of cross-border human mobility in the successive SARS-CoV-2 introductions in Burkina Faso from neighboring countries. Conclusions: This study provides additional insights into the genomic epidemiology of SARS-CoV-2 in West Africa. It highlights the importance of land travel in the spread of the virus and the need to rapidly implement preventive policies. Regional cross-border collaborations and the adherence of the general population to government policies are key to prevent new epidemic waves.\</p\>},

keywords = {Burkina Faso, COVID-19, genomic epidemiology, SARS-Cov-2, West Africa, Whole Genome Sequencing},

pubstate = {published},

tppubtype = {article}

}