Research and professional experience:

1. Positions and Employment

Start date – End date:Postes

2018 to present : Senior Research scientist, CRUN-IRSS, Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso

2009 to present : Clinical trial coordinator (CRUN-IRSS Burkina Faso)

2006 to present : Trainer “effective project planning and evaluation in biomedical research” (WHO-TDR)

2013 – 2014 : Temporary advisor “mapping of neglected tropical diseases” (WHO-Afro)

2006 – 2008 : Research fellow(IRSS-Bobo-Dioulasso)

2000 – 2006 : PhD candidate (University of Ouagadougou, Burkina Faso)

2. Personal Statemen

(provide a short description of your research interest and/or motivation/ fournir une brève description de vos centres d’intérêt et/ou motivation)

My main area of interest in research covers human immune response to parasitic infection and parasitic diseases and control through vaccination. I worked on several research projects on the control of malaria and schistosomiasis.

Recently I invested some effort in public health approaches to improve health during the early infancy and also in understanding the interactions between genomic and environmental factors that influence health in early infancy and late adulthood.

Other Experience and Professional Memberships

Start date – End date: 

3. Selected Peer-reviewed Publications

Watson D, Kehoe SH, Erzse A, Compaoré A, Debpuur C, Nonterah EA, Sorgho H, Norris SA, Hofman KJ, Lawrence W, Newell ML, Godfrey KM, Ward KA, Barker M; INPreP group. (2020). Community perspectives on maternal and child health during nutrition and economic transition in sub-Saharan Africa. Public Health Nutrition 2020 Sep 15:1-9.   doi: 10.1017/S1368980020003018

Boua PR, Brandenburg JT, Choudhury A, Hazelhurst S, Sengupta D, Agongo G, Nonterah EA, Oduro AR, Tinto H, Mathew CG, Sorgho H, Ramsay M. (2020). Novel and known gene-smoking interactions with cIMT identified as potential drivers for atherosclerosis risk in West-African populations of the AWI-Gen study. Frontiers in Genetics. 2020 Feb 7;10:1354.   doi: 10.3389/fgene.2019.01354

George JA, Brandenburg JT, Fabian J, Crowther NJ, Agongo G, Alberts M, Ali S, Asiki G, Boua PR, Gómez-Olivé FX, Mashinya F, Micklesfield L, Mohamed SF, Mukomana F, Norris SA, Oduro AR, Soo C, Sorgho H, Wade A, Naicker S, Ramsay M; AWI-Gen and the H3Africa Consortium. (2019). Kidney damage and associated risk factors in rural and urban sub-Saharan Africa (AWI-Gen): a cross-sectional population study. Lancet Global Health. 2019 Dec;7(12):e1632-e1643. doi: 10.1016/S2214-109X(19)30443-7

Ali SA, Soo C, Agongo G, Alberts M, Amenga-Etego L, Boua RP, Choudhury A, Crowther NJ, Depuur C, Gómez-Olivé FX, Guiraud I, Haregu TN, Hazelhurst S, Kahn K, Khayeka-Wandabwa C, Kyobutungi C, Lombard Z, Mashinya F, Micklesfield L, Mohamed SF, Mukomana F, Nakanabo-Diallo S, Natama HM, Ngomi N, Nonterah EA, Norris SA, Oduro AR, Somé AM, Sorgho H, Tindana P, Tinto H, Tollman S, Twine R, Wade A, Sankoh O, Ramsay M. (2018). Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study. Global Health Action. 2018;11(sup2):1507133. doi: 10.1080/16549716.2018.1507133.

Boua RP, Sorgho H, Rouamba T, Nakanabo Diallo S, Bognini JD, Konkobo SZ, Valia D, Lingani M, Ouoba S, Tougma AS, Bihoun B, Crowther NJ, Norris SA, Ramsay M, Tinto H; as members of AWI-Gen and the H3Africa Consortium. (2018). Gender differences in sociodemographic and behavioural factors associated with BMI in an adult population in rural Burkina Faso – an AWI-Gen sub-study. Global Health Action. 2018;11(sup2):1527557. doi: 10.1080/16549716.2018.1527557.

Ramsay M, Crowther NJ, Agongo G, Ali SA, Asiki G, Boua RP, Gómez-Olivé FX, Kahn K, Khayeka-Wandabwa C, Mashinya F, Micklesfield L, Mukomana F, Nonterah EA, Soo C, Sorgho H, Wade AN, Wagner RG, Alberts M, Hazelhurst S, Kyobutungi C, Norris SA, Oduro AR, Sankoh O, Tinto H, Tollman S & as members of AWI-Gen and the H3Africa Consortium (2018). Regional and sex-specific variation in BMI distribution in four sub-Saharan African countries: The H3Africa AWI-Gen study. Global Health Action. 2018;11(sup2):1556561. doi: 10.1080/16549716.2018.1556561

Gómez-Olivé FX, Ali SA, Made F, Kyobutungi C, Nonterah E, Micklesfield L, Alberts M, Boua R, Hazelhurst S, Debpuur C, Mashinya F, Dikotope S, Sorgho H, Cook I, Muthuri S, Soo C, Mukomana F, Agongo G, Wandabwa C, Afolabi S, Oduro A, Tinto H, Wagner RG, Haregu T, Wade A, Kahn K, Norris SA, Crowther NJ, Tollman S, Sankoh O, Ramsay M; as members of AWI-Gen and the H3Africa Consortium. (2017). Regional and sex differences in the prevalence and awareness of hypertension: An H3Africa AWI-Gen study across 6 sites in Sub-Saharan Africa. Global Heart. 2017 Jun;12(2):81-90. doi: 10.1016/j.gheart.2017.01.007

H3Africa Consortium (2014). Research capacity. Enabling the genomic revolution in Africa. Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546

Valéa I, Adjei S, Usuf E, Traore O, Ansong D, Tinto H, Owusu Boateng H, Some AM, Buabeng P, Vekemans J, Kotey A, Vandoolaeghe P, Cullinane M, Traskine M, Ouedraogo F, Sambian D, Lievens M, Tahita MC, Jongert E, Lompo P, Idriss A, Borys D, Ouedraogo S, Prempeh F, Schuerman L, Sorgho H, Agbenyega T. (2020).Long-term immunogenicity and immune memory response to the hepatitis B antigen in the RTS,S/AS01_E malaria vaccine in African children: a randomized trial. Human Vaccines and Immunotherapeutics. 2020 Jun 2;16(6):1464-1470.   doi: 10.1080/21645515.2019.1695457

Sondo P, Derra K, Rouamba T, Nakanabo Diallo S, Taconet P, Kazienga A, Ilboudo H, Tahita MC, Valéa I, Sorgho H, Lefèvre T, Tinto H. (2020). Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso. Parasites and Vectors. 2020 Aug 20;13(1):427.   doi: 10.1186/s13071-020-04302-z

Sondo P, Derra K, Lefevre T, Diallo-Nakanabo S, Tarnagda Z, Zampa O, Kazienga A, Valea I, Sorgho H, Ouedraogo JB, Guiguemde TR, Tinto H. (2019). Genetically diverse Plasmodium falciparum infections, within-host competition and symptomatic malaria in humans. Scientific Reports. 2019 Jan 15;9(1):127.   doi: 10.1038/s41598-018-36493-y.

Dobaño C, Sanz H, Sorgho H, Dosoo D, Mpina M, Ubillos I, Aguilar R, Ford T, Díez-Padrisa N, Williams NA, Ayestaran A, Traore O, Nhabomba AJ, Jairoce C, Waitumbi J, Agnandji ST, Kariuki S, Abdulla S, Aponte JJ, Mordmüller B, Asante KP, Owusu-Agyei S, Tinto H, Campo JJ, Moncunill G, Gyan B, Valim C, Daubenberger C. (2019). Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy. Nature Communications. 2019 May 15;10(1):2174.   doi: 10.1038/s41467-019-10195-z.

Tinto H, Otieno W, Gesase S, Sorgho H, Otieno L, Liheluka E, Valéa I, Sing’oei V, Malabeja A, Valia D, Wangwe A, Gvozdenovic E, Guerra Mendoza Y, Jongert E, Lievens M, Roman F, Schuerman L, Lusingu J. (2019). Long-term incidence of severe malaria following RTS,S/AS01 vaccination in children and infants in Africa: an open-label 3-year extension study of a phase 3 randomised controlled trial. Lancet Infectious Diseases. 2019 Aug;19(8):821-832.   doi: 10.1016/S1473-3099(19)30300-7

Early AM, Lievens M, MacInnis BL, Ockenhouse CF, Volkman SK, Adjei S, Agbenyega T, Ansong D, Gondi S, Greenwood B, Hamel M, Odero C, Otieno K, Otieno W, Owusu-Agyei S, Asante KP, Sorgho H, Tina L, Tinto H, Valea I, Wirth DF, Neafsey DE. (2018). Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections. Nature Communications. 2018 Apr 11;9(1):1381. doi: 10.1038/s41467-018-03807-7.

Natama HM, Rovira-Vallbona E, Somé MA, Zango SH, Sorgho H, Guetens P, Coulibaly-Traoré M, Valea I, Mens PF, Schallig HDFH, Kestens L, Tinto H, Rosanas-Urgell A. (2018). Malaria incidence and prevalence during the first year of life in Nanoro, Burkina Faso: a birth-cohort study. Malaria Journal. 2018 Apr 12;17(1):163. doi: 10.1186/s12936-018-2315-4.

Natama HM, Rovira-Vallbona E, Sorgho H, Somé MA, Traoré-Coulibaly M, Scott S, Zango SH, Sawadogo O, Zongo SC, Valéa I, Mens PF, Schallig HDFH, Kestens L, Tinto H, Rosanas-Urgell A. (2018). Additional screening and treatment of malaria during pregnancy provides further protection against malaria and nonmalarial fevers during the first year of life. Journal of Infectious Diseases. 2018 May 25;217(12):1967-1976. doi: 10.1093/infdis/jiy140.

Valéa I, Adjei S, Usuf E, Traore O, Ansong D, Tinto H, Owusu Boateng H, Leach A, Mwinessobaonfou Some A, Buabeng P, Vekemans J, Nana LA, Kotey A, Vandoolaeghe P, Ouedraogo F, Sambian D, Lievens M, Tahita MC, Rettig T, Jongert E, Lompo P, Idriss A, Borys D, Ouedraogo S, Prempeh F, Habib MA, Schuerman L, Sorgho H, Agbenyega T. (2018). Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: A randomized controlled trial. Human Vaccines and Immunotherapeutics. 2018 Jun 3;14(6):1489-1500.   doi: 10.1080/21645515.2018.1442996

Ubillos I, Ayestaran A, Nhabomba AJ, Dosoo D, Vidal M, Jiménez A, Jairoce C, Sanz H, Aguilar R, Williams NA, Díez-Padrisa N, Mpina M, Sorgho H, Agnandji ST, Kariuki S, Mordmüller B, Daubenberger C, Asante KP, Owusu-Agyei S, Sacarlal J, Aide P, Aponte JJ, Dutta S, Gyan B, Campo JJ, Valim C, Moncunill G, Dobaño C. (2018). Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children. BMC Medicine. 2018 Oct 31;16(1):197. doi: 10.1186/s12916-018-1186-4

Natama HM, Moncunill G, Rovira-Vallbona E, Sanz H, Sorgho H, Aguilar R, Coulibaly-Traoré M, Somé MA, Scott S, Valéa I, Mens PF, Schallig HDFH, Kestens L, Tinto H, Dobaño C, Rosanas-Urgell A. (2018). Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life. BMC Medicine. 2018 Nov 2;16(1):198. doi: 10.1186/s12916-018-1187-3

Sorgho H, Douamba KRD, Valea I, Tinto H. (2017). Performance diagnostique de SD Bioline malaria antigen P.f® pour la détection des infections palustres chez la femme enceinte au troisième trimestre de grossesse au Burkina Faso. Science et Technique, Sciences de la santéVol. 40, n°2, 81-87.

Natama HM, Ouedraogo DF, Sorgho H, Rovira-Vallbona E, Serra-Casas E, Somé MA, Coulibaly-Traoré M, Mens PF, Kestens L, Tinto H, Rosanas-Urgell A. (2017). Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing. Scientific Reports, 2017 May 18;7(1):2080. doi: 10.1038/s41598-017-02173-6.

Somé AF, Sorgho H, Zongo I, Bazié T, Nikiéma F, Sawadogo A, Zongo M, Compaoré YD, Ouédraogo JB. (2016). Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso. Parasite. 2016; 23:60. doi: 10.1051/parasite/2016069.

Tinto H, Sombié O, Valea I, Lankoandé F, Yara S, Lompo P, Tahita MC, Kazienga A, Ouédraogo S, Sorgho H, De Crop M, Ravinetto R. (2015). Field evaluation of SD-Bioline malaria antigen P.f® for Plasmodium falciparum malaria diagnosis in Nanoro, Burkina Faso. African Journal of Parasitology Research, 4 (11), 161-165.

Sondo P, Valea I, Biebo B, Sorgho H, Kazienga A, Ouedraogo J-B, Guiguemdé TR, Tinto H. (2015). La part du paludisme dans les maladies fébriles en saison sèche dans la région de Nanoro, Burkina Faso. West African Medical Journal, Jun 9;21:101. doi: 10.11604/pamj.2015.21.101.6437. eCollection 2015.

Neafsey DE, Juraska M, Bedford T, Benkeser D, Valim C, Griggs A, Lievens M, Abdulla S, Adjei S, Agbenyega T, Agnandji ST, Aide P, Anderson S, Ansong D, Aponte JJ, Asante KP, Bejon P, Birkett AJ, Bruls M, Connolly KM, D’Alessandro U, Dobaño C, Gesase S, Greenwood B, Grimsby J, Tinto H, Hamel MJ, Hoffman I, Kamthunzi P, Kariuki S, Kremsner PG, Leach A, Lell B, Lennon NJ, Lusingu J, Marsh K, Martinson F, Molel JT, Moss EL, Njuguna P, Ockenhouse CF, Ogutu BR, Otieno W, Otieno L, Otieno K, Owusu-Agyei S, Park DJ, Pellé K, Robbins D, Russ C, Ryan EM, Sacarlal J, Sogoloff B, Sorgho H, Tanner M, Theander T, Valea I, Volkman SK, Yu Q, Lapierre D, Birren BW, Gilbert PB, Wirth DF. (2015). Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine. New England Journal of Medicine, 2015 (373) 21: 2025-2037. doi: 10.1056/NEJMoa1505819.

White MT, Verity R, Griffin JT, Asante KP, Owusu-Agyei S, Greenwood B, Drakeley C, Gesase S, Lusingu J, Ansong D, Adjei S, Agbenyega T, Ogutu B, Otieno L, Otieno W, Agnandji ST, Lell B, Kremsner P, Hoffman I, Martinson F, Kamthunzu P, Tinto H, Valea I, Sorgho H, Oneko M, Otieno K, Hamel MJ, Salim N, Mtoro A, Abdulla S, Aide P, Sacarlal J, Aponte JJ, Njuguna P, Marsh K, Bejon P, Riley EM, Ghani AC. (2015). Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial. Lancet Infectious Diseases, 15: 1450–1458. doi: 10.1016/S1473-3099(15)00239-X

RTS,S Clinical Trials Partnership (2015). Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet, 2015 Jul 4;386(9988):31-45. doi: 10.1016/S0140-6736(15)60721-8.

Tinto H, Valea I, Sorgho H, Tahita MC, Traore M, Bihoun B, Guiraud I, Kpoda H, Rouamba J, Ouédraogo S, Lompo P, Yara S, Kabore W, Ouédraogo JB, Guiguemdé RT, Binka FN, Ogutu B. (2014) The impact of clinical research activities on communities in rural Africa: the development of the clinical research unit of Nanoro (CRUN) in Burkina Faso. Malaria Journal. 2014 Mar 22;13:113. doi: 10.1186/1475-2875-13-113

RTS,S Clinical Trials Partnership (2012). A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. New England Journal of Medicine, 2012 Dec 13;367(24):2284-95.   doi: 10.1056/NEJMoa1208394.

RTS, S Clinical Trials Partnership (2011). First results of phase 3 Trial of RTS,S/AS01 malaria vaccine in African children.New England Journal of Medicine 17;365(20):1863-75. doi: 10.1056/NEJMoa1102287

Valea I, Tinto H, Drabo MK, Huybregts L, Sorgho H, Ouedraogo JB, Guiguemde RT, van Geertruyden JP, Kolsteren P, D’Alessandro U; FSP/Misame Study Group (2012). An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. Malaria Journal2012 Mar 16;11:71. doi: 10.1186/1475-2875-11-71.

Zeba AN, Sorgho H, Rouamba N, Zongo I, Rouamba J, Guiguemdé RT, Hamer DH, Mokhtar N, Ouedraogo JB. (2008). Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double-blind trial. Nutrition Journal, 31, 7:7.   doi: 10.1186/1475-2891-7-7

Sorgho H, Da O, Rouamba T, Savadogo B, Tinto H, Ouedraogo J-B. (2017). Schistosoma mansoni infection and hematological profile in an endemic foci in Western Burkina Faso. African Journal of Parasitology Research, 4 (10), 264-270.

Bagayan M, Zongo D, Oueda A, Sorgho H, Savadogo B, Drabo F, Ouedraogo A, Poda JN, Kabre BG, Zhang Y. (2016). Prevalence of schistosomiasis and soil-transmitted helminth infections among schoolchildren in Burkina Faso. Médecine et Santé Tropicale. 2016 Aug 1;26(3):267-272.   doi: 10.1684/mst.2016.0570

Bagayan M, Zongo D, Ouéda A, Savadogo B, Sorgho H, Drabo F, Ouédraogo A, Bamba I, Zhang Y, Kabré GB, Poda JN. (2015). Prevalence of Hymenolepis nana among primary school children in Burkina Faso. International Journal of Medicine and Medical Sciences. 7(10): 148-153, December 2015.  doi: 10.5897/IJMMS2015.1179

Kpoda NW, Sorgho H, Poda JN, Ouédraogo JB, Kabré GB. (2013). Schistosomiasis caused by Schistosoma mansoni in the Kou valley: Characterization of the transmission system and socioeconomic impact. Comptes Rendus Biologies 2013 May-Jun;336(5-6):284-8. doi: 10.1016/j.crvi.2013.04.008.

Bahgat M, Sorgho H, Ouédraogo JB, Poda JN, Sawadogo L, Ruppel A. (2006).Enzyme-linked immunosorbent assay with worm vomit and cercarial secretions of Schistosoma mansoni to detect infections in an endemic focus of Burkina Faso.Journal of Helminthology, 80, 19-23.   doi: 10.1079/joh2005312

Sorgho H., Bahgat M., Poda J-N, Song W, Kirsten C, Doenhoff MJ., Zongo I, Ouédraogo J-B, Ruppel A. (2005). Serodiagnosis of Schistosoma mansoni infections in an endemic area of Burkina Faso : performance of several immunological tests with different parasite antigens. Acta Tropica, 93, 169-180.   doi: 10.1016/j.actatropica.2004.10.006

Poda JN, Wango SP, Sorgho H, Dianou D. (2004). Evolution récente des schistosomoses dans le complexe hydroagricole du Sourou au Burkina Faso. Bulletin de la Société de Pathologie Exotique, 97, 1, 15-18.

Dianou D, odaJN P, Sorgho H, Wango SP, Sondo KB. (2003). Hydraulic plannings and Schistosomiasis: Case of Sourou in Burkina Faso. Journal of Applied Research in Veterinary Medicine, 1, 2, 105-111.

4. Research Support

(Sponsor-Start date – End date: Position) /(Structure de financement-Début-Fin): Postes

Study of immune correlates of protection against malaria after vaccination with RTS, S/AS01E. MVI funded. 2010 – 2013. Principal Investigator

Understanding RTS,S malaria vaccine-induced protection through integrated analysis. NIH funded. 2013 – 2018. Principal Investigator

Genomic and environmental risk factors for cardiometabolic diseases in Africans. NIH funded. 2014 – 2021. Co-Principal Investigator

Leveraging improved nutrition preconception, during pregnancy and postpartum in Sub-Saharan Africa through novel intervention models. NIHR funded. 2018 – 2022. Principal Investigator