Hamidou Ilboudo

Research and professional experience:

1. Personal Statement

My research career started in 2006 when I joined the “Institut de Recherche en Sciences de la Sante (IRSS)” in Bobo Dioulasso (Burkina Faso) working on the impact of the polymorphism of the kdr gene on the biting behaviour of the molecular form M of Anopheles gambiae in response to repellents which was a hugely enjoyable and rewarding time and fired my enthusiasm for research. After completing my MSc in 2007, I decided to apply the skills and techniques I had developed to the study of human African trypanosomiasis (HAT) for my PhD so I moved to “Centre International de Recherche-Développement sur l’Elevage en Zone Subhumide” ((CIRDES), Burkina-Faso and obtained my PhD in 2012 awarded by the Polytechnic University of Bobo-Dioulasso (Burkina-Faso). For my thesis, I performed a better phenotypic characterization of the clinical diversity observed in HAT, in particular the existence of trypanotolerant individuals able to control infection. I also showed for the first time, through immunological studies that the nature of the immune response is very different between the susceptible individuals (HAT patients) and individuals who resist naturally to infection. After my PhD, I undertook post-doctoral studies in CIRDES (May 2012-June 2017) on the host genetic susceptibility in HAT within the TrypanoGEN project funded by the Wellcome Trust. For my post-doctoral, I showed that APOL1 polymorphisms (G1, G2) are associated with HAT. In July 2017, I joined the Institut de Recherche pour le Développement” (IRD) as post-doctoral researcher and based in Guinea National control program against HAT where I has been working on elimination of HAT in Guinea HAT foci. These successes favoured my recruitment at the IRSS/ “Unité de Recherche Clinique de Nanoro (URCN) as permanent researcher in November 2017.

2. Positions and Employment

-Since November 2017 : permanent position at the Institut de Recherche en Science de la Santé (IRSS) / Unité de Recherche Clinique de Nanoro (URCN)

-From July 2017 to October 2017: post-doctoral researcher at the “Institut de Recherche pour le Développement” (IRD) based to the Guinea National control program against HAT(Conakry).

-From May 2012 to June 2017: Researcher at the CIRDES

Other Experience and Professional Memberships

Member of WHO Collaborating Center for research on host/vector/parasite interactions for surveillance and control of Human African Trypanosomiasis

3. Selected Peer-reviewed Publications 

Mulindwa J, Noyes H, Ilboudo H, Pagani L, Nyangiri O, Kimuda MP, Ahouty B, Asina OF, Ofon E, Kamoto K, Kabore JW, Koffi M, Ngoyi DM, Simo G, Chisi J, Sidibe I, Enyaru J, Simuunza M, Alibu P, Jamonneau V, Camara M, Tait A, Hall N, Bucheton B, MacLeod A, Hertz-Fowler C, Matovu E; TrypanoGEN Research Group of the H3Africa Consortium. High Levels of Genetic Diversity within Nilo-Saharan Populations: Implications for Human Adaptation. Am J Hum Genet. 2020 Sep 3;107(3):473-486. doi: 10.1016/j.ajhg.2020.07.007. Epub 2020 Aug 10.

Nyangiri OA, Noyes H, Mulindwa J, Ilboudo H, Kabore JW, Ahouty B, Koffi M, Asina OF, Mumba D, Ofon E, Simo G, Kimuda MP, Enyaru J, Alibu VP, Kamoto K, Chisi J, Simuunza M, Camara M, Sidibe I, MacLeod A, Bucheton B, Hall N, Hertz-Fowler C, Matovu E; TrypanoGEN Research Group, as members of The H3Africa Consortium. Copy number variation in human genomes from three major ethno-linguistic groups in Africa. BMC Genomics. 2020 Apr 10;21(1):289. doi: 10.1186/s12864-020-6669-y.

2019

Dama E, Camara O, Kaba D, Koffi M, Camara M, Compaoré C, Ilboudo H, Courtin F, Kaboré J, N’Gouan EK, Büscher P, Lejon V, Bucheton B, Jamonneau V. Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis. Parasite. 2019;26:68. doi: 10.1051/parasite/2019066. Epub 2019 Nov 22

Kaboré JW, Camara O, Ilboudo H, Capewell P, Clucas C, Cooper A, Kaboré J, Camara M, Jamonneau V, Hertz-Fowler C, Bélem AMG, Matovu E, Macleod A, Sidibé I, Noyes H, Bucheton B ; TrypanoGEN Research Group, as member of the H3Africa Consortium. Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infect Genet Evol. 2019 Mar 23;71:108-115. doi: 10.1016/j.meegid.2019.03.021.

2018

informal Expert Group on Gambiense HAT Reservoirs, Büscher P, Bart J-M, Boelaert M, Bucheton B, Chitnis N, Courtin D, Figueiredo LM, Franco J-R, Grébaut P, Hasker E, Ilboudo H, Jamonneau V, Koffi M, Lejon V, MacLeod A, Masumu J, Matovu E, Mattioli R, Noyes H, Picado A, Rock KS, Rotureau B, Simo G, Thévenon S, Trindade S, Truc P, Reet VN (informal expert group gambiense reservoirs). Do cryptic reservoir threaten gambiense-sleeping sickness elimination? Trends in parasitology. ttp://dx.doi.org/10.1016/j.pt.2017.11.008

2017

N’Djetch MK, Ilboudo H, Koff M, Kaboré J, Kaboré J, Kaba D, Courtin F, Bamoro C, Fauret P, Kouakou L, Ravel S, Deborggraeve S, Solano P, De Meeûs T, Bucheton B, Jamonneau V. The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d’Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. LoS Negl Trop Dis 11(10): e0005993. https://doi.org/10.1371/journal.pntd.0005993

Bernadin A, Koffi M, Ilboudo H, Simo G, Matovu E, Mulindwa J, Hertz-Fowler C, Bucheton B, Sidibé I, Jamonneau V, MacLeod A, Noyes H, N’Guetta1 SP, for the TrypanoGEN Research Group as members of The H3Africa Consortium. Candidate genes-based investigation of susceptibility to Human African. PLoS Negl Trop Dis. 2017 Oct 23;11(10):e0005992. doi: 10.1371/journal.pntd.0005992

Kaboré JW, Ilboudo H, Noyes H, Camara O, Kaboré J, Camara M, Koffi M, Lejon V, Jamonneau V, MacLeod A, Hertz-Fowler C, Belem AMG, Matovu E, Bucheton B, Sidibé I, TrypanoGEN Research Group as members of the H3Africa Consortium. Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. PLoS Negl Trop Dis 11(8): e0005833. https://doi.org/10.1371/journal.pntd.0005833.

Ilboudo H, Noyes H, Mulindwa J, Kimuda MP, Koffi M, Kaboré JW, Ahouty B, Ngoyi DM, Fataki O, Simo G, Ofon E, Enyaru J, Chisi J, Kamoto K, Simuunza M, Alibu VP, Lejon V, Jamonneau V, Macleod A, Camara M, Bucheton B, Hertz-Fowler C, Sidibe I, Matovu E; TrypanoGEN Research Group as members of The H3Africa Consortium. Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis. PLoS Negl Trop Dis. 2017 Jun 1;11(6):e0005438. doi: 10.1371/journal.pntd.0005438. eCollection 2017 Jun.

Cooper A, Ilboudo H, Alibu VP, Ravel S, Enyaru J, Weir W, Noyes H, Capewell P, Camara M, Milet J, Jamonneau V, Camara O, Matovu E, Bucheton B, MacLeod. APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. Elife. 2017 May 24;6. pii: e25461. doi: 10.7554/eLife.25461.

2016

Ilboudo H, Jamonneau V, Koffi M, Kaboré J, Amoussa R, Holzmuller P, Garcia A, Bucheton B, Courtin D. Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections. Microbes Infect. 2016 Jun;18(6):436-40. doi: 10.1016/j.micinf.2016.03.002. Epub 2016 Mar 16.

2015

Ilboudo H, Camara O, Ravel S, Bucheton B, Lejon V, Camara M, Kaboré J, Jamonneau V, Deborggraeve S (2015). The trypanosome’s spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than DNA. (DOI: 10.1093/infdis/jiv337).

4. Research Support

Wellcome Trust. 2018-2021. TrypanoGEN +. The genetic determinant of two neglected tropical diseases (human African trypanosomiasis and schistosomiasis). Collaborator.

European and Developing Countries Clinical Trials Partnership (EDCTP). 2016-2019. Diagnostic tools for human African trypanosomiasis elimination and clinical trials (DiTECT)-HAT. Co-Pi

Wellcome Trust, H3Africa. 2012-2018. TrypanoGEN: an integrated approach to identification of genetic determinants of susceptibility to trypanosomiasis. Participant.

“Institut de Recherche pour le Développement (IRD) /Jeune Equipe Associée de I’IRD (JEAI)”. 2014-2017. Epidemiological study of the role of trypanotolerant individual and domestic animals in maintaining the transmission of T. b. gambiense in West and Central Ivory Coast foci. Co-pi.

“Union Economique et Monétaire Ouest Africaine (UEMOA) /Programme d’Appui à l’Enseignement Supérieur (PAES). 2013-2014. The role of domestic animals in the transmission of T. b. gambiense in West and Central Ivory Coast foci: Perspective for a sustainable control of sleeping sickness. Co-pi