| Surina Singh, Ananyo Choudhury, Scott Hazelhurst, Nigel Crowther, Palwende Boua, Hermann Sorgho, Godfred Agongo, Engelbert Nonterah, Lisa Micklesfield, Shane Norris, Isaac Kisiangani, Shukri Mohamed, Francesc Gomez-Olive, Stephen Tollman, Solomon Choma, Jean-Tristan Brandenburg, Michele Ramsay Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study Journal Article In: Research square, 2023, ISSN: 2693-5015. @article{Singh2023,
title = {Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study},
author = {Surina Singh and Ananyo Choudhury and Scott Hazelhurst and Nigel Crowther and Palwende Boua and Hermann Sorgho and Godfred Agongo and Engelbert Nonterah and Lisa Micklesfield and Shane Norris and Isaac Kisiangani and Shukri Mohamed and Francesc Gomez-Olive and Stephen Tollman and Solomon Choma and Jean-Tristan Brandenburg and Michele Ramsay},
url = {https://pubmed.ncbi.nlm.nih.gov/36824767/ http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9949264},
doi = {10.21203/RS.3.RS-2532794/V1},
issn = {2693-5015},
year = {2023},
date = {2023-01-01},
journal = {Research square},
publisher = {Res Sq},
abstract = {Most hypertension-related genome-wide association studies (GWAS) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure-related traits (systolic and diastolic blood pressure, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N=10,775), identified two genome-wide significant signals (p\<5E-08): systolic blood pressure near P2RY1 (rs77846204; intergenic variant},
keywords = {Ananyo Choudhury, doi:10.21203/rs.3.rs-2532794/v1, MEDLINE, Mich\`{e}le Ramsay, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, PMC9949264, pmid:36824767, Preprint, PubMed Abstract, Surina Singh},
pubstate = {published},
tppubtype = {article}
}
Most hypertension-related genome-wide association studies (GWAS) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure-related traits (systolic and diastolic blood pressure, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N=10,775), identified two genome-wide significant signals (p<5E-08): systolic blood pressure near P2RY1 (rs77846204; intergenic variant |
