@article{Post2019-iz,

title = {The XN-30 hematology analyzer for rapid sensitive detection of  malaria: a diagnostic accuracy study},

author = {Annelies Post and Berenger Kabor\'{e} and Isaie J Reuling and Joel Bognini and Wouter Heijden and Salou Diallo and Palpouguini Lompo and Basile Kam and Natacha Herssens and Kjerstin Lanke and Teun Bousema and Robert W Sauerwein and Halidou Tinto and Jan Jacobs and Quirijn Mast and Andre J Ven},

doi = {10.1186/s12916-019-1334-5},

issn = {1741-7015},

year  = {2019},

date = {2019-05-01},

urldate = {2019-05-01},

journal = {BMC Med.},

volume = {17},

number = {1},

pages = {103},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Accurate and timely diagnosis of malaria is 

 essential for disease management and surveillance. Thin and 

 thick blood smear microscopy and malaria rapid diagnostic tests 

 (RDTs) are standard malaria diagnostics, but both methods have 

 limitations. The novel automated hematology analyzer XN-30 

 provides standard complete blood counts (CBC) as well as 

 quantification of malaria parasitemia at the price of a CBC. 

 This study assessed the accuracy of XN-30 for malaria detection 

 in a controlled human malaria infection (CHMI) study and a phase 

 3 diagnostic accuracy study in Burkina Faso. METHODS: Sixteen 

 healthy, malaria-naive CHMI participants were challenged with 

 five Plasmodium falciparum-infected mosquitoes. Blood was 

 sampled daily for XN-30, blood smear microscopy, and malaria 

 qPCR. The accuracy study included patients aged \> 3 months 

 presenting with acute febrile illness. XN-30, microscopy, and 

 rapid diagnostic tests (HRP-2/pLDH) were performed on site; qPCR 

 was done in retrospect. The malaria reference standard was 

 microscopy, and results were corrected for sub-microscopic 

 cases. RESULTS: All CHMI participants became parasitemic by qPCR and XN-30 with a strong correlation for parasite density (R2 = 

 0.91; p \< .0001). The XN-30 accurately monitored treatment and 

 allowed detection of recrudescence. Out of 908 patients in the 

 accuracy study, 241 had microscopic malaria (density 24-491,802 

 parasites/$mu$L). The sensitivity and specificity of XN-30 compared to microscopy were 98.7% and 99.4% (PPV = 98.7},

keywords = {Burkina Faso; Diagnosis; Malaria; Sensitivity; Specificity},

pubstate = {published},

tppubtype = {article}

}