@article{Compaore2018-hd,

title = {Fear and rumours regarding placental biopsies in a  malaria-in-pregnancy trial in Benin},

author = {Ad\'{e}la"ide Compaor\'{e} and Susan Dierickx and Fatou Jaiteh and Alain Nahum and Towanou Francis Emmanuel Bohissou and Halidou Tinto and Susana Scott and Umberto D'Alessandro and Henk Schallig and Koen Peeters Grietens},

doi = {10.1186/s12936-018-2578-9},

issn = {1475-2875},

year  = {2018},

date = {2018-11-01},

urldate = {2018-11-01},

journal = {Malar. J.},

volume = {17},

number = {1},

pages = {425},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: A multi-country, community-based trial on scheduled 

 screening and treatment for malaria in pregnancy was conducted 

 in Benin, The Gambia and Burkina Faso. Despite standardized 

 procedures and outcomes, the study became subject to rumours and 

 accusations of placenta being sold for mystical and financial 

 gain by trial staff, leading to drop-out rates of 30% and the 

 consequent halting of placental biopsy sampling in Benin. This 

 paper explores the role of socio-cultural beliefs related to 

 placenta and identified additional factors contributing these 

 rumours. METHODS: A qualitative comparative emergent-theory 

 design was used to assess social factors related to trial 

 implementation and uptake in the three countries. Data from 

 participant observation, informal conversations, group 

 discussions and interviews were triangulated and analysed with 

 NVivo Qualitative Analysis software. RESULTS: Despite similar 

 sociocultural beliefs about the sacred nature of the placenta in 

 all three study countries, these beliefs did not affect 

 participation rates in Burkina Faso and The Gambia and 

 placenta-related rumours only emerged in Benin. Therefore, the 

 presence of beliefs is not a sufficient condition to have 

 generated placenta-selling fears. The rumours in Benin reflected 

 the confluence of placenta-related beliefs and factors related 

 to the implementation of the trial (including a catalysing 

 adverse event and miscommunication during the informed consent 

 procedure). Furthermore, distinct socio-political factors 

 contributed to the emergence of rumours, including the 

 historical distrust in governmental organizations and the tense 

 relationship between some of the actors involved in the trial. 

 CONCLUSION: Transdisciplinary social science research designs 

 should accompany the implementation of the trial. The 

 integration of multiple stakeholders' knowledge and involvement 

 is required to define and solve upcoming barriers.},

keywords = {Clinical trial; Community health worker; Malaria; Placenta;   Pregnancy; Rumour},

pubstate = {published},

tppubtype = {article}

}