 | Stuart A Ali, Cassandra Soo, Godfred Agongo, Marianne Alberts, Lucas Amenga-Etego, Romuald P Boua, Ananyo Choudhury, Nigel J Crowther, Cornelius Depuur, F Xavier Gómez-Olivé, Issa Guiraud, Tilahun N Haregu, Scott Hazelhurst, Kathleen Kahn, Christopher Khayeka-Wandabwa, Catherine Kyobutungi, Zané Lombard, Felistas Mashinya, Lisa Micklesfield, Shukri F Mohamed, Freedom Mukomana, Seydou Nakanabo-Diallo, Hamtandi M Natama, Nicholas Ngomi, Engelbert A Nonterah, Shane A Norris, Abraham R Oduro, Athanase M Somé, Hermann Sorgho, Paulina Tindana, Halidou Tinto, Stephen Tollman, Rhian Twine, Alisha Wade, Osman Sankoh, Mich`ele Ramsay Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study (Journal Article) In: Glob. Health Action, vol. 11, no. sup2, pp. 1507133, 2018, ISSN: 1654-9716. @article{Ali2018-fu,
title = {Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study},
author = {Stuart A Ali and Cassandra Soo and Godfred Agongo and Marianne Alberts and Lucas Amenga-Etego and Romuald P Boua and Ananyo Choudhury and Nigel J Crowther and Cornelius Depuur and F Xavier G\'{o}mez-Oliv\'{e} and Issa Guiraud and Tilahun N Haregu and Scott Hazelhurst and Kathleen Kahn and Christopher Khayeka-Wandabwa and Catherine Kyobutungi and Zan\'{e} Lombard and Felistas Mashinya and Lisa Micklesfield and Shukri F Mohamed and Freedom Mukomana and Seydou Nakanabo-Diallo and Hamtandi M Natama and Nicholas Ngomi and Engelbert A Nonterah and Shane A Norris and Abraham R Oduro and Athanase M Som\'{e} and Hermann Sorgho and Paulina Tindana and Halidou Tinto and Stephen Tollman and Rhian Twine and Alisha Wade and Osman Sankoh and Mich`ele Ramsay},
doi = {10.1080/16549716.2018.1507133},
issn = {1654-9716},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
journal = {Glob. Health Action},
volume = {11},
number = {sup2},
pages = {1507133},
publisher = {Informa UK Limited},
abstract = {There is an alarming tide of cardiovascular and metabolic
disease (CMD) sweeping across Africa. This may be a result of an
increasingly urbanized lifestyle characterized by the growing
consumption of processed and calorie-dense food, combined with
physical inactivity and more sedentary behaviour. While the link
between lifestyle and public health has been extensively studied
in Caucasian and African American populations, few studies have
been conducted in Africa. This paper describes the detailed
methods for Phase 1 of the AWI-Gen study that were used to
capture phenotype data and assess the associated risk factors
and end points for CMD in persons over the age of 40 years in
sub-Saharan Africa (SSA). We developed a population-based
cross-sectional study of disease burden and phenotype in
Africans, across six centres in SSA. These centres are in West
Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East
Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale
and Soweto). A total of 10,702 individuals between the ages of
40 and 60 years were recruited into the study across the six
centres, plus an additional 1021 participants over the age of 60
years from the Agincourt centre. We collected socio-demographic,
anthropometric, medical history, diet, physical activity, fat
distribution and alcohol/tobacco consumption data from
participants. Blood samples were collected for disease-related
biomarker assays, and genomic DNA extraction for genome-wide
association studies. Urine samples were collected to assess
kidney function. The study provides base-line data for the
development of a series of cohorts with a second wave of data
collection in Phase 2 of the study. These data will provide
valuable insights into the genetic and environmental influences
on CMD on the African continent.},
keywords = {AWI-Gen; African populations; Cardiometabolic disease; H3Africa; burden of disease},
pubstate = {published},
tppubtype = {article}
}
There is an alarming tide of cardiovascular and metabolic
disease (CMD) sweeping across Africa. This may be a result of an
increasingly urbanized lifestyle characterized by the growing
consumption of processed and calorie-dense food, combined with
physical inactivity and more sedentary behaviour. While the link
between lifestyle and public health has been extensively studied
in Caucasian and African American populations, few studies have
been conducted in Africa. This paper describes the detailed
methods for Phase 1 of the AWI-Gen study that were used to
capture phenotype data and assess the associated risk factors
and end points for CMD in persons over the age of 40 years in
sub-Saharan Africa (SSA). We developed a population-based
cross-sectional study of disease burden and phenotype in
Africans, across six centres in SSA. These centres are in West
Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East
Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale
and Soweto). A total of 10,702 individuals between the ages of
40 and 60 years were recruited into the study across the six
centres, plus an additional 1021 participants over the age of 60
years from the Agincourt centre. We collected socio-demographic,
anthropometric, medical history, diet, physical activity, fat
distribution and alcohol/tobacco consumption data from
participants. Blood samples were collected for disease-related
biomarker assays, and genomic DNA extraction for genome-wide
association studies. Urine samples were collected to assess
kidney function. The study provides base-line data for the
development of a series of cohorts with a second wave of data
collection in Phase 2 of the study. These data will provide
valuable insights into the genetic and environmental influences
on CMD on the African continent. |
