Publications

@article{Neyer2024,

title = {Increased erythroferrone levels in malarial anaemia},

author = {Peter J. Neyer and B\'{e}renger Kabor\'{e} and Christos T. Nakas and Salou Diallo and Halidou Tinto and Annelies Post and Andre J. Ven and Andreas R. Huber and Carlo R. Largiad\`{e}r and Angelika Hammerer-Lercher},

url = {https://pubmed.ncbi.nlm.nih.gov/38279554/},

doi = {10.1111/BJH.19309},

issn = {1365-2141},

year  = {2024},

date = {2024-01-01},

journal = {British journal of haematology},

volume = {204},

issue = {5},

pages = {2066-2070},

publisher = {Br J Haematol},

abstract = {We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.},

keywords = {Anemia, Anemia / blood, Anemia / etiology, Angelika Hammerer-Lercher, Animals, B\'{e}renger Kabor\'{e}, Biomarkers* / blood, doi:10.1111/bjh.19309, Female, Hepcidins / blood, Humans, Iron / blood, Iron / metabolism, Iron-Deficiency / blood, Malaria* / blood, Malaria* / complications, Male, MEDLINE, Mice, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peptide Hormones* / blood, Peter J Neyer, pmid:38279554, PubMed Abstract},

pubstate = {published},

tppubtype = {article}

}

@article{Millogo2024,

title = {Trend of N86Y and Y184F Mutations in Pfmdr1 Gene in Children Under Seasonal Malaria Chemoprevention Coverage in Nanoro, Burkina Faso},

author = {Ki\'{e} Solange Millogo and B\'{e}renger Kabor\'{e} and Paul Sondo and Eulalie W. Compaor\'{e} and Am\'{e}l\'{e} Fifi Chantal Kouevi and Si\'{e} A. Elis\'{e}e Kambou and Toussaint Rouamba and Adama Kazienga and Hamidou Ilboudo and Marc Christian Tahita and Ismaila Bouda and Karim Derra and Sanata Bamba and Halidou Tinto},

url = {https://pubmed.ncbi.nlm.nih.gov/39356425/},

doi = {10.1007/S11686-024-00923-X},

issn = {1896-1851},

year  = {2024},

date = {2024-01-01},

journal = {Acta parasitologica},

publisher = {Acta Parasitol},

abstract = {Background: Seasonal malaria chemoprevention (SMC) is an effective malaria preventive intervention in sub-Sahara Africa. However, as with any other drug-based intervention, the large-scale deployment of this strategy could lead to Amodiaquine plus Sulfadoxine-Pyrimethamine (AQSP) drug pressure on the circulating parasites population with selection for specific alleles that could compromise the impact of the intervention in the near future. This study aimed to assess the distribution of the Pfmdr1 mutation involved in resistance to AQ before and after the annual campaign of SMC in the health district of Nanoro. Methods: Randomly selected dried blood spots collected prior (n = 100) and after (n = 100) the 2021 SMC campaign were used for the detection of mutation in codons 86 and 184 of the Pfmdr1 gene using a nested PCR with restriction fragment length polymorphism approach. Results: No significant change in the prevalence of Pfmdr1 N86Y mutation was observed before and after the SMC campaign (p = 0.28). The mutant allele 86Y was observed at low prevalences, representing only 2.17% and 6.12%, respectively, before and after the SMC campaign. Patients harboring the mutant Pfmdr1 86Y allele exhibited higher parasite densities compared to patients with the wild-type Pfmdr1 N86 allele (p = 0.04). A significant increase in the prevalence of the mutant allele 184 F was observed in the period before and after the SMC campaign (p = 0.03). Conclusion: This selective pressure needs to be closely monitored in order to preserve the efficacy of this intervention for a long-term period in Burkina Faso.},

keywords = {B\'{e}renger Kabor\'{e}, doi:10.1007/s11686-024-00923-x, Halidou Tinto, Ki\'{e} Solange Millogo, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, pmid:39356425, PubMed Abstract},

pubstate = {published},

tppubtype = {article}

}

@article{Neyer2023,

title = {Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study},

author = {Peter J. Neyer and B\'{e}renger Kabor\'{e} and Christos T. Nakas and Britta Hartmann and Annelies Post and Salou Diallo and Halidou Tinto and Angelika Hammerer-Lercher and Carlo R. Largiad\`{e}r and Andre J. Ven and Andreas R. Huber},

url = {https://pubmed.ncbi.nlm.nih.gov/37658365/},

doi = {10.1186/S12936-023-04686-0},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: Asymptomatic Plasmodium falciparum parasitaemia forms a reservoir for the transmission of malaria disease in West Africa. Certain haemoglobin variants are known to protect against severe malaria infection. However, data on the potential roles of haemoglobin variants and nongenetic factors in asymptomatic malaria infection is scarce and controversial. Therefore, this study investigated the associations of iron homeostasis, inflammation, nutrition, and haemoglobin mutations with parasitaemia in an asymptomatic cohort from a P. falciparum-endemic region during the high transmission season. Methods: A sub-study population of 688 asymptomatic individuals (predominantly children and adolescents under 15 years},

keywords = {Adolescent, Andreas R Huber, Asymptomatic Infections / epidemiology, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Child, doi:10.1186/s12936-023-04686-0, Falciparum* / epidemiology, hemoglobin, Hepcidins*, Humans, Malaria, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Peter J Neyer, Plasmodium falciparum / genetics, PMC10474782, pmid:37658365, PubMed Abstract, Sickle},

pubstate = {published},

tppubtype = {article}

}

@article{Sondo2023,

title = {Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial},

author = {Paul Sondo and B\'{e}renger Kabor\'{e} and Toussaint Rouamba and Eulalie Compaor\'{e} and Yssimini Nad\`{e}ge Guill\`{e}ne Tibiri and Hyacinthe Abd El Latif Fa\"{i}\c{c}al Kabor\'{e} and Karim Derra and Marc Christian Tahita and Hamidou Ilboudo and Gauthier Tougri and Isma\"{i}la Bouda and Tikanou Dakyo and Hyacinthe Kafando and Florence Ou\'{e}draogo and Eli Rouamba and So Franck Hien and Adama Kazienga and Cheick Sa\"{i}d Compaor\'{e} and Estelle Bambara and Macaire Nana and Prabin Dahal and Franck Garanet and William Kabor\'{e} and Thierry L\'{e}f\`{e}vre and Philippe Guerin and Halidou Tinto},

url = {https://pubmed.ncbi.nlm.nih.gov/37853408/},

doi = {10.1186/S12936-023-04745-6},

issn = {1475-2875},

year  = {2023},

date = {2023-01-01},

journal = {Malaria journal},

volume = {22},

issue = {1},

publisher = {Malar J},

abstract = {Background: In rural African settings, most of the children under the coverage of Seasonal Malaria Chemoprevention (SMC) are also undernourished at the time of SMC delivery, justifying the need for packaging malarial and nutritional interventions. This study aimed at assessing the impact of SMC by coupling the intervention with nutrients supplementation for preventing malaria in children less than 5 years old in Burkina Faso. Methods: A randomized trial was carried out between July 2020 and June 2021 in the health district of Nanoro, Burkina Faso. Children (n = 1059) under SMC coverage were randomly assigned to one of the three study arms SMC + Vitamin A (SMC-A},

keywords = {Antimalarials* / therapeutic use, B\'{e}renger Kabor\'{e}, Burkina Faso / epidemiology, Chemoprevention, Child, Cross-Sectional Studies, Dietary Supplements, doi:10.1186/s12936-023-04745-6, Halidou Tinto, Humans, Infant, Malaria* / epidemiology, MEDLINE, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, NIH, NLM, Nutrients, Paul Sondo, PMC10585892, pmid:37853408, Preschool, PubMed Abstract, Randomized controlled trial, Seasons, Vitamin A / therapeutic use},

pubstate = {published},

tppubtype = {article}

}